KaydedilenlerDerginizi ekleyin

Dergiler / Biyolojik Çeşitlilik ve Koruma / 2026 / Volume: 19 Issue: 1

Probiyotiklerden postbiyotiklere: erkek üreme sağlığında mikrobiyal yaklaşımlar

From probiotics to postbiotics: microbial approaches in male reproductive health

Gamze Zengin(KUTAHYA HEALTH SCIENCES UNIVERSITY)0000-0002-5215-6088
Kerem Azkeskin(KUTAHYA HEALTH SCIENCES UNIVERSITY)0009-0002-7609-8617
Fatih Kar(KUTAHYA HEALTH SCIENCES UNIVERSITY)0000-0001-8356-9806
Sayfa
—
Yayın Tarihi
2026-02-16
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bu derlemenin amacı, mikrobiyal yaklaşımların erkek üreme sağlığı üzerindeki etkilerini incelemek ve bağırsak mikrobiyotasının düzenlenmesi yoluyla fertiliteyi iyileştirebilecek güncel bulguları derlemektir.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Probiyotiklerden Postbiyotiklere: Erkek Üreme Sağlığında Mikrobiyal Yaklaşımlar Özet Amaç: Fertilite, bireyin üreme sağlığını ve üreme kapasitesini ifade ederken; infertilite, sağlıklı bir gebelik elde edememe durumudur.
📊
Temel Bulgular & Veri:Bu derlemenin amacı, mikrobiyal yaklaşımların erkek üreme sağlığı üzerindeki etkilerini incelemek ve bağırsak mikrobiyotasının düzenlenmesi yoluyla fertiliteyi iyileştirebilecek güncel bulguları derlemektir.
💡
Sonuç & Katkı:Anahtar Kelimeler: Mikrobiyota, İnfertilite, Prebiyotikler, Probiyotikler, Postbiyotikler, FMT
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Microbiota · Infertility · Prebiotics

Özet

Probiyotiklerden Postbiyotiklere: Erkek Üreme Sağlığında Mikrobiyal Yaklaşımlar Özet Amaç: Fertilite, bireyin üreme sağlığını ve üreme kapasitesini ifade ederken; infertilite, sağlıklı bir gebelik elde edememe durumudur. Bu derlemenin amacı, mikrobiyal yaklaşımların erkek üreme sağlığı üzerindeki etkilerini incelemek ve bağırsak mikrobiyotasının düzenlenmesi yoluyla fertiliteyi iyileştirebilecek güncel bulguları derlemektir. Yöntem: Araştırma, çeşitli bilimsel veri tabanlarından (PubMed, Google Scholar, Scopus) elde edilen makaleler kullanılarak yapılan bir literatür taramasına dayanmaktadır. Derleme, probiyotikler, postbiyotikler ve fekal mikrobiyota transplantasyonu (FMT) dahil olmak üzere diğer mikrobiyal tedavi yaklaşımlarının erkek üreme sağlığı üzerindeki etkilerini ele alan çalışmalara odaklanmıştır. Bulgular: Çalışmalar, mikrobiyom dengesizliğinin sperm üretimini, testosteron seviyelerini ve sperm kalitesini olumsuz etkileyerek erkek üreme sağlığını bozduğunu göstermektedir. Prebiyotikler, probiyotikler, postbiyotikler ve FMT gibi mikrobiyom temelli terapiler, mikrobiyal dengeyi yeniden sağlayabilir, faydalı mikroorganizmaları destekleyebilir ve biyolojik olarak aktif bileşikler sunabilir. Bu müdahaleler, sperm kalitesini artırma, hormon seviyelerini düzenleme ve genel erkek üreme sağlığını iyileştirme potansiyeline sahiptir. Sonuç: Bu derleme, mikrobiyal tedavi yaklaşımlarının erkek üreme sağlığını iyileştirmedeki potansiyelini vurgulamaktadır. Bağırsak mikrobiyotasının dengelenmesi yoluyla bu terapiler, erkek infertilitesine yönelik umut verici stratejiler sunmaktadır. Bulgular, üreme tıbbında mikrobiyom temelli tedavilerin gelişimi, etkinliği ve potansiyel uygulama alanları hakkında kapsamlı bir anlayış sağlamaktadır. Anahtar Kelimeler: Mikrobiyota, İnfertilite, Prebiyotikler, Probiyotikler, Postbiyotikler, FMT

Abstract

From Probiotics to Postbiotics: Microbial Approaches in Male Reproductive Health Gamze ZENGİN 1, Kerem AZKESKİN 2, Fatih KAR 2 ORCID: 0000-0002-5215-6088; 0009-0002-7609-8617; 0000-0001-8356-9806. 1 Kütahya University of Health Sciences, Department of Medical Biology, Kütahya, 43000, Turkey. 2 Kütahya University of Health Sciences, Department of Medical Biochemistry, Kütahya, 43000, Turkey. Purpose: Fertility refers to an individual's reproductive health and capacity for reproduction, while infertility is the inability to achieve a healthy pregnancy. The purpose of this review is to examine the impact of microbial approaches on male reproductive health and to compile current findings on how gut microbiota regulation can improve fertility outcomes. Method: A literature search was conducted using articles obtained from various scientific databases (PubMed, Google Scholar, Scopus). The review focused on studies addressing the effects of probiotics, postbiotics, and other microbial therapeutic approaches, including fecal microbiota transplantation (FMT), on male reproductive health. Findings: The studies indicate that microbiome imbalance negatively affects male reproductive health by impairing sperm production, testosterone levels, and sperm quality. Microbiome-based therapies, including prebiotics, probiotics, postbiotics, and FMT, can restore microbial balance, support beneficial microorganisms, and provide biologically active compounds. These interventions have the potential to improve sperm quality, regulate hormone levels, and enhance overall male reproductive health. Conclusion: This review highlights the potential of microbial therapeutic approaches in improving male reproductive health. By regulating gut microbiota balance, these therapies offer promising strategies for addressing male infertility. The findings provide a comprehensive understanding of the development, effectiveness, and potential applications of microbiome-based treatments in reproductive medicine. Keywords: Microbiota, Infertility, Prebiotics, Probiotics, Postbiotics, FMT.

🔖

Bu Makaleye Atıf Yap

Zengin, G., Azkeskin, K., Kar, F. (2026). Probiyotiklerden postbiyotiklere: erkek üreme sağlığında mikrobiyal yaklaşımlar. Biyolojik Çeşitlilik ve Koruma, Volume: 19 Issue: 1. https://doi.org/10.46309/biodicon.2026.1838383

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (35)

  1. Kucuk, S., & Koruk, F. (2022). Being an infertile woman in a highly fertile region of Turkey: Stigmatisation and coping experiences. Electron J Gen Med. 2022; 19 (2): em346. In (Vol. 19, pp. 2). https://doi.org/10.29333/ejgm/11545
  2. Kaltsas, A., Zachariou, A., Markou, E., Dimitriadis, F., Sofikitis, N., & Pournaras, S. (2023). Microbial dysbiosis and male infertility: understanding the impact and exploring therapeutic interventions. Journal of personalized medicine, 13(10), 1491. https://doi.org/10.3390/jpm13101491
  3. Agarwal, A., Baskaran, S., Parekh, N., Cho, C.-L., Henkel, R., Vij, S., Arafa, M., Selvam, M. K. P., & Shah, R. (2021). Male infertility. The Lancet, 397(10271), 319-333. https://doi.org/10.1016/S0140-6736(20)32667-2
  4. Li, J., Li, Y., Cheng, M., Ye, F., Li, W., Wang, C., Huang, Y., Wu, Y., Xuan, R., & Liu, G. (2022). Gut microbial diversity among Yorkshire, Landrace and Duroc boars and its impact on semen quality. Amb Express, 12(1), 158. https://doi.org/10.1186/s13568-022-01496-6
  5. Zhang, Y., Hou, B., Liu, T., Wu, Y., & Wang, Z. (2023). Probiotics improve polystyrene microplastics-induced male reproductive toxicity in mice by alleviating inflammatory response. Ecotoxicology and Environmental Safety, 263, 115248. https://doi.org/10.1016/j.ecoenv.2023.115248
  6. Lv, S., Huang, J., Luo, Y., Wen, Y., Chen, B., Qiu, H., Chen, H., Yue, T., He, L., & Feng, B. (2024). Gut microbiota is involved in male reproductive function: A review. Frontiers in Microbiology, 15, 1371667. https://doi.org/10.3389/fmicb.2024.1371667
  7. Zhu, Y., Du, Q., Jiao, N., Shu, A., Gao, Y., Chen, J., Lv, G., Lu, J., Chen, Y., & Xu, H. (2021). Catalpol ameliorates diabetes-induced testicular injury and modulates gut microbiota. Life Sciences, 267, 118881. https://doi.org/10.1016/j.lfs.2020.118881
  8. Castellini, C., Mattioli, S., Moretti, E., Cotozzolo, E., Perini, F., Dal Bosco, A., Signorini, C., Noto, D., Belmonte, G., & Lasagna, E. (2022). Expression of genes and localization of enzymes involved in polyunsaturated fatty acid synthesis in rabbit testis and epididymis. Scientific reports, 12(1), 2637. https://doi.org/10.1038/s41598-022-06700-y
  9. Lin, Y., Li, J., Wang, K., Fang, Z., Che, L., Xu, S., Feng, B., Zhuo, Y., Li, J., & Wu, D. (2022). Effects of dietary L-leucine supplementation on testicular development and semen quality in boars. Frontiers in Veterinary Science, 9, 904653. https://doi.org/10.3389/fvets.2022.904653
  10. Davani-Davari, D., Negahdaripour, M., Karimzadeh, I., Seifan, M., Mohkam, M., Masoumi, S. J., Berenjian, A., & Ghasemi, Y. (2019). Prebiotics: definition, types, sources, mechanisms, and clinical applications. Foods, 8(3), 92. https://doi.org/10.3390/foods8030092
  11. Bindels, L. B., Delzenne, N. M., Cani, P. D., & Walter, J. (2015). Towards a more comprehensive concept for prebiotics. Nature reviews Gastroenterology & hepatology, 12(5), 303-310. https://doi.org/10.1038/nrgastro.2015.47
  12. Ashonibare, V. J., Akorede, B. A., Ashonibare, P. J., Akhigbe, T. M., & Akhigbe, R. E. (2024). Gut microbiota-gonadal axis: the impact of gut microbiota on reproductive functions. Frontiers in immunology, 15, 1346035. https://doi.org/10.3389/fimmu.2024.1346035
  13. Cai, H., Cao, X., Qin, D., Liu, Y., Liu, Y., Hua, J., & Peng, S. (2022). Gut microbiota supports male reproduction via nutrition, immunity, and signaling. Frontiers in Microbiology, 13, 977574. https://doi.org/10.3389/fmicb.2022.977574
  14. Rousseaux, C., Thuru, X., Gelot, A., Barnich, N., Neut, C., Dubuquoy, L., Dubuquoy, C., Merour, E., Geboes, K., & Chamaillard, M. (2007). Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. Nature medicine, 13(1), 35-37. https://doi.org/10.1038/nm1521
  15. Rowe, M., Veerus, L., Trosvik, P., Buckling, A., & Pizzari, T. (2020). The reproductive microbiome: an emerging driver of sexual selection, sexual conflict, mating systems, and reproductive isolation. Trends in ecology & evolution, 35(3), 220-234. https://doi.org/10.1016/j.tree.2019.11.004
  16. Wang, H., Xu, A., Gong, L., Chen, Z., Zhang, B., & Li, X. (2022). The microbiome, an important factor that is easily overlooked in male infertility. Frontiers in Microbiology, 13, 831272. https://doi.org/10.3389/fmicb.2022.831272
  17. Bui, A. D., Sharma, R., Henkel, R., & Agarwal, A. (2018). Reactive oxygen species impact on sperm DNA and its role in male infertility. Andrologia, 50(8), e13012. https://doi.org/10.1111/and.13012
  18. Cao, T., Wang, S., Pan, Y., Guo, F., Wu, B., Zhang, Y., Wang, Y., Tian, J., Xing, Q., & Liu, X. (2023). Characterization of the semen, gut, and urine microbiota in patients with different semen abnormalities. Frontiers in Microbiology, 14, 1182320. https://doi.org/10.3389/fmicb.2023.1182320
  19. Akram, M., Ali, S. A., Behare, P., & Kaul, G. (2022). Dietary intake of probiotic fermented milk benefits the gut and reproductive health in mice fed with an obesogenic diet. Food & Function, 13(2), 737-752. https://doi.org/10.1039/d1fo02501e
  20. Poutahidis, T., Haigis, K. M., Rao, V. P., Nambiar, P. R., Taylor, C. L., Ge, Z., Watanabe, K., Davidson, A., Horwitz, B. H., & Fox, J. G. (2007). Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. Carcinogenesis, 28(12), 2614-2623. https://doi.org/10.1093/carcin/bgm180
  21. Edem, E. E., Nathaniel, B. U., Nebo, K. E., Obisesan, A. O., Olabiyi, A. A., Akinluyi, E. T., & Ishola, A. O. (2021). Lactobacillus plantarum mitigates sexual-reproductive deficits by modulating insulin receptor expression in the hypothalamic-pituitary-testicular axis of hyperinsulinemic mice. Drug Metab Pers Ther, 36(4), 321-336. https://doi.org/10.1515/dmpt-2021-1000195
  22. Sanchez-Rodriguez, A., Idrovo, I. I. D., Villafranca, R., Latorre, N., Rielo, J. A., Laburu, A., Nieto-Roman, S., Heredia, D., Gonzalez, R., Garcia-Canas, V., Laxalde, D., Simo, C., Vieites, D. R., & Roldan, E. R. S. (2025). Effect of Probiotics on Sperm Quality in the Adult Mouse. Probiotics Antimicrob Proteins, 17(6), 4480-4490. https://doi.org/10.1007/s12602-024-10388-z
  23. Mändar, R., Smidt, I., Rööp, T., Hoidmets, D., Kilk, K., Zilmer, M., Ausmees, K., & Salumets, A. (2025). Development of Probiotics for Male Reproductive Tract Health: In Vitro Experiments and Clinical Trial on Healthy Volunteers. Andrologia, 2025(1), 7000428. https://doi.org/10.1155/and/7000428
  24. Wu, J., Zhou, T., Shen, H., Jiang, Y., Yang, Q., Su, S., Wu, L., Fan, X., Gao, M., & Wu, Y. (2024). Mixed probiotics modulated gut microbiota to improve spermatogenesis in bisphenol A-exposed male mice. Ecotoxicology and Environmental Safety, 270, 115922. https://doi.org/10.1016/j.ecoenv.2023.115922
  25. Chibbar, R., & Dieleman, L. A. (2015). Probiotics in the management of ulcerative colitis. Journal of clinical gastroenterology, 49, S50-S55. https://doi.org/10.1097/mcg.0000000000000368
  26. Salminen, S., Collado, M. C., Endo, A., Hill, C., Lebeer, S., Quigley, E. M., Sanders, M. E., Shamir, R., Swann, J. R., & Szajewska, H. (2021). The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nature reviews Gastroenterology & hepatology, 18(9), 649-667. https://doi.org/10.1038/s41575-021-00440-6
  27. Khani, N., Shakeri, A. H., Houshmandi, S., Ziavand, M., Abedi-Soleimani, R., Hosseinzadeh, N., & Homayouni-Rad, A. (2025). The promising biological role of postbiotics in treating human infertility. Probiotics and Antimicrobial Proteins, 1-13. https://doi.org/10.1007/s12602-025-10458-w
  28. Hashem, N. M., & Gonzalez-Bulnes, A. (2022). The use of probiotics for management and improvement of reproductive eubiosis and function. Nutrients, 14(4), 902. https://doi.org/10.3390/nu14040902
  29. Carrageta, D. F., Oliveira, P. F., Alves, M. G., & Monteiro, M. P. (2019). Obesity and male hypogonadism: Tales of a vicious cycle. Obesity Reviews, 20(8), 1148-1158. https://doi.org/10.1111/obr.12863
  30. Zhang, J., Liu, H., Yang, Q., Li, P., Wen, Y., Han, X., Li, B., Jiang, H., & Li, X. (2020). Genomic sequencing reveals the diversity of seminal bacteria and relationships to reproductive potential in boar sperm. Frontiers in Microbiology, 11, 1873. https://doi.org/10.3389/fmicb.2020.01873
  31. Aitken, R. J., Smith, T. B., Jobling, M. S., Baker, M. A., & De Iuliis, G. N. (2014). Oxidative stress and male reproductive health. Asian journal of andrology, 16(1), 31-38. https://doi.org/10.4103/1008-682x.122203
  32. Zhang, C., Xiong, B., Chen, L., Ge, W., Yin, S., Feng, Y., Sun, Z., Sun, Q., Zhao, Y., & Shen, W. (2021). Rescue of male fertility following faecal microbiota transplantation from alginate oligosaccharide-dosed mice. Gut, 70(11), 2213-2215. https://doi.org/10.1136/gutjnl-2020-323593
  33. Hao, Y., Feng, Y., Yan, X., Chen, L., Zhong, R., Tang, X., Shen, W., Sun, Q., Sun, Z., & Ren, Y. (2022). Gut microbiota-testis axis: FMT improves systemic and testicular micro-environment to increase semen quality in type 1 diabetes. Molecular Medicine, 28(1), 45. https://doi.org/10.1186/s10020-022-00473-w
  34. Yan, X., Feng, Y., Hao, Y., Zhong, R., Jiang, Y., Tang, X., Lu, D., Fang, H., Agarwal, M., & Chen, L. (2022). Gut-testis axis: microbiota prime metabolome to increase sperm quality in young type 2 diabetes. Microbiology spectrum, 10(5), e01423-01422. https://doi.org/10.1128/spectrum.01423-22
  35. Zhao, Q., Huang, J.-F., Cheng, Y., Dai, M.-Y., Zhu, W.-F., Yang, X.-W., Gonzalez, F. J., & Li, F. (2021). Polyamine metabolism links gut microbiota and testicular dysfunction. Microbiome, 9(1), 224. https://doi.org/10.1186/s40168-021-01157-z