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Dergiler / Balıkesir Sağlık Bilimleri Dergisi / 2026 / Volume: 13 Issue: 2

Kırım-Kongo Kanamalı Ateşi Hastalarında Mortalitenin Belirleyicisi Olarak Laktat/Albümin Oranı

Lactate/Albumin Ratio as a Predictor of Mortality in Patients with Crimean-Congo Hemorrhagic Fever

Yusuf Kenan Tekin(CUMHURİYET ÜNİVERSİTESİ TIP FAKÜLTESİ)0000-0001-8047-4836
Şimşek Çelik(SİVAS CUMHURİYET ÜNİVERSİTESİ, SİVAS ARAŞTIRMA VE UYGULAMA MERKEZİ)0000-0003-1574-235X
Sayfa
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Yayın Tarihi
2024-08-28
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Sağ kalan ve sağ kalan olmayan hastaların bulguları karşılaştırıldı.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amaç: Bu çalışma, KKH hastalarında laktat/albümin (L / A) oranının prognoz ve mortalite ile ilişkisini belirlemeyi amaçlamıştır.
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Temel Bulgular & Veri:Gereç ve Yöntem: Ocak 2019 ile Aralık 2022 tarihleri arasında KKH tanısı almış, 36'sı mortalite, 224'ü canlı olmak üzere toplam 260 hasta retrospektif olarak çalışmaya dahil edildi.
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Sonuç & Katkı:Sağ kalan ve sağ kalan olmayan hastaların bulguları karşılaştırıldı.
🔬Tür:Laboratuvar & Saha Deneyi
📍Kapsam:2019 · 260 hasta
⚙️Değişkenler:Emergency Department · Crimean-Congo Hemorrhagic Fever · Lactate/Albumin Ratio

Özet

Amaç: Bu çalışma, KKH hastalarında laktat/albümin (L / A) oranının prognoz ve mortalite ile ilişkisini belirlemeyi amaçlamıştır. Gereç ve Yöntem: Ocak 2019 ile Aralık 2022 tarihleri arasında KKH tanısı almış, 36'sı mortalite, 224'ü canlı olmak üzere toplam 260 hasta retrospektif olarak çalışmaya dahil edildi. Sağ kalan ve sağ kalan olmayan hastaların bulguları karşılaştırıldı. Bulgular: Gruplar arasında yaş ve cinsiyet açısından anlamlı fark yoktu. KKKA nedeniyle ölen hasta grubunda albumin, glukoz ve trombosit düzeyleri oldukça düşük iken (p<0,001); Kanda beyaz kan hücreleri, üre nitrojen, kreatinin, alanin aminotransferaz, aspartat aminotransferaz, sodyum, laktat, L/A oranı ve yüksek duyarlıklı C-reaktif protein anlamlı düzeyde yüksek bulundu (p<0,05). ROC analizinde en yüksek duyarlılık ve özgüllük L/A oranı olarak hesaplandı. Sonuç: L/A oranının KKKA hastalarında fataliteyi öngörmede bir araç olarak kullanılabileceğini bulduk. Ek olarak, L/A oranı, fataliteyi öngörmede tek başına serum albümin ve serum laktat düzeylerine göre daha anlamlıydı.

Abstract

Objective:This study aimed to determine the relationship of lactate/albumin (L/A) ratio with prognosis and fatality in CCHF patients. Materials and Methods: A total of 260 patients diagnosed with CCHF between January 2019 and December 2022, 36 of whom were deceased and 224 of whom were alive, were retrospectively included in the study. The findings of survivor and non-survivor patients were compared. Results: There was no significant difference between the groups in terms of age and gender. While albumin, glucose and platelet levels were quite low in the patient group who died due to CCHF (p<0.001); White blood cells, urea nitrogen, creatinine, alanine aminotransferase, aspartate aminotransferase, sodium, lactate, L/A ratio and high-sensitivity C-reactive protein in the blood were found to be significantly high (p<0.05). In the ROC analysis, the highest sensitivity and specificity were calculated as the L/A ratio. Conclusion: We found that the L/A ratio can be used as a tool to predict fatality in CCHF patients. In addition, the L/A ratio was more significant in predicting fatality than serum albumin and serum lactate levels alone.

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Bu Makaleye Atıf Yap

Tekin, Y. K., Çelik, Ş. (2024). Kırım-Kongo Kanamalı Ateşi Hastalarında Mortalitenin Belirleyicisi Olarak Laktat/Albümin Oranı. Balıkesir Sağlık Bilimleri Dergisi, Volume: 13 Issue: 2. https://doi.org/10.53424/balikesirsbd.1422074

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Kaynakça (29)

  1. Appannanavar, S. B., & Mishra, B. (2011). An Update on Crimean Congo Hemorrhagic Fever. Journal of Global Infectious Diseases, 3(3),285–292. https://doi.org/10.4103/0974-777X.83537
  2. Binici, İ., Tarcan, T., Parlak, M., İncecik, Ş., Huyut, Z., & Akbay, H. İ., et al. (2022). Kırım-Kongo kanamalı ateşi olgularının retrospektif olarak incelenmesi. Van Sag Bil Derg, 15(3),294-300. https://doi.org/10.52976/vansaglik.1192996
  3. Bou Chebl, R., Jamali, S., Sabra, M., Safa, R., Berbari, I., & Shami, A., et al. (2020). Lactate/albumin ratio as a predictor of in-hospital mortality in septic patients presenting to the emergency department. Frontiers in Medicine (Lausanne), 22(7),550182. https://doi.org/10.3389/fmed.2020.550182. eCollection 2020.
  4. Cakir, E., & Ozkocak Turan, I. (2021). Lactate/albumin ratio is more effective than lactate or albumin alone in predicting clinical outcomes in intensive care patients with sepsis. Scandinavian Journal of Clinical and Laboratory Investigation 81(3),225-229. https://doi.org/10.1080/00365513.2021.1901306.
  5. Chebl, R. B., Geha, M., Assaf, M., Kattouf, N., Haidar, S., & Abdeldaem, K., et al. (2021) The prognostic value of the lactate/albumin ratio for predicting mortality in septic patients presenting to the emergency department: a prospective studys. Annals of Medicine, 53(1), 2268–2277. https://doi.org/ 10.1080/07853890.2021.2009125.
  6. Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., & Opal, S. M. et al. (2013). Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Critical Care Medicine, 41(2),580–637. https://doi.org/10.1097/CCM.0b013e31827e83af.
  7. Filho, R. R., Rocha, L. L., Corrêa, T. D., Pessoa Camila, M.S., Colombo, G., & Cesar Assuncao, M. S. (2016). Blood lactate levels cutoff and mortality prediction in sepsis-time for a reappraisal? A retrospective cohort study. Shock, 46(5), 480–485. https://doi.org/ 10.1097/SHK.0000000000000667
  8. Fillâtre, P., Revest, M., & Tattevin, P. (2019). Crimean Congo hemorrhagic fever: An update. Medecine et Maladies Infectieuses, 49(8),574-585. https://doi.org/10.1016/j.medmal.2019.09.005.
  9. Friedman, G., De Backer, D., Shahla, M., & Vincent, J. L. (1998). Oxygen supply dependency can characterize septic shock. Intensive Care Medicine, 24(2), 118–123. https://doi.org/10.1007/s001340050531.
  10. Gharipour, A., Razavi, R., Gharipour, M., & Mukasa, D.(2020). Lactate/albumin ratio: An early prognostic marker in critically ill patients. The American journal of Emergency Medicine, 38(10), 2088–2095. https://doi.org/10.1016/j.ajem.2020.06.067.
  11. Gul, S., Ozturk, D. B., Kisa, U., Kacmaz, B., & Yesilyurt, M. (2015). Procalcitonin Level and Its Predictive Effect on Mortality in Crimean-Congo Hemorrhagic Fever. Japanese Journal of Infectious Diseases, 68(6), 511-513. https://doi.org/10.7883/yoken.JJID.2014.485.
  12. Hawman, D. W., & Feldmann, H. (2018). Recent advances in understanding Crimean–Congo hemorrhagic fever virüs [version 1; referees: 4 approved] F1000Research 7(F1000 Faculty Rev), 1715. https://doi.org/10.12688/f1000research.16189.1
  13. Hawman, G. R., Buzgan, T., Irmak, H., Safran, A., Uzun, R., & Cevik, M. A., et al. The epidemiology of Crimean-Congo hemorrhagic fever in Turkey, 2002–2007. (2009). International Journal of Infectious Diseases, 13(3), 380-386 https://doi.org/10.1016/j.ijid.2008.07.021.
  14. Kazan, F.G., & Sümer, H. (2019). Tokat il merkezinde Kırım Kongo kanamalı ateşi (KKKA) ön tanısıyla hastanede yatan hastaların, KKKA hastalığı hakkında bilgi düzeyi. Ankara Medical Journal, 19(2), 381-395. https://doi.org/10.17098/amj.576498.
  15. Kerget, F., Kerget, B., & İba Yılmaz, S. (2021). The Association Between Procalcitonin, Lactate Level, and Clinical Prognosis in Patients with Crimean-Congo Hemorrhagic Fever. Duzce Medical Journal, 23(3), 299-304. https://doi.org/10.18678/dtfd.1012774.
  16. Kokulu, K., & Sert, E. T. (2021). The role of the lactate/albumin ratio in predicting survival outcomes in patients resuscitated after out-of-hospital cardiac arrest: A preliminary report. The American Journal of Emergency Medicine, 50, 670-674. https://doi.org/10.1016/j.ajem.2021.09.059.
  17. Lau, K. K., Hsiao, C. T., Fann, W. C., & Chang, C. P. (2021). Utility of the Lactate/Albumin Ratio as a Predictor for Mortality in Necrotizing Fasciitis Patients. Emergency Medicine International, 2021, 353029. https://doi.org/10.1155/2021/3530298.
  18. Lee, J. W., You, J. S., Chung, S. P., Choa, M., Kong, T., & Ko, D. R., et al. (2019). Lactate/albumin ratio for the prediction of the development of sepsis-induced acute kidney injury in the emergency department. Journal of the Korean Society of Emergency Medicine, 30(1), 22-32. https://doi.org/10.0000/jksem.2019.30.1.22.
  19. Lu, Y., Guo, H., Chen, X., & Zhang Q. (2021). Association between lactate/albumin ratio and all-cause mortality in patients with acute respiratory failure: A retrospective analysis. PLoS One, 16(8), e0255744. https://doi.org/10.1371/journal.pone.0255744.
  20. Mikkelsen, M. E., Miltiades, A. N., Gaieski, D. F., Goyal, M., Fuchs, B. D., & Shah, C. V., et al. (2009). Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Critical Care Medicine, 37(5), 1670–1677. https://doi.org/10.1097/CCM.0b013e31819fcf68.
  21. Öngürü, P., & Bodur, H. (2012). Crimean-congo haemorrhagic fever. Journal of Experimental and Clinical Medicine, 29, 175-181. https://doi.org/10.5835/jecm.omu.29.s3.014.
  22. Özmen, Z., & Parlak, Z. (2020). Abdominal US Findings of Crimean-Congo Hemorrhagic Fever. Journal of Contemporary Medicine, 10(2), 261-265. https://doi.org/10.16899/jcm.652354.
  23. Shapiro, N.I., Howell, M.D., Talmor, D., Nathanson, L.A., Lisbon, A., & Wolfe, R.E., et al. (2005). Serum lactate as a predictor of mortality in emergency department patients with infection. Ann Emerg Med, 45(5), 524–528. https://doi.org/10.1016/j.annemergmed.2004.12.006.
  24. Shin, J., Hwang, S.Y., Jo, I.J.,, Kim, W.Y., Ryoo, S.M., & Kang, G.H., et al. (2018). Prognostic value of the lactate/albumin ratio for predicting 28-day mortality in critically ill sepsis patients. Shock, 50(5), 545–550.https://doi.org/10.1097/SHK.0000000000001128.
  25. Swanepoel, R., Gill, D.E., Shepherd, A.J., Leman, P.A., Mynhardt, J.H., & Harvey, S. (1989). The Clinical Pathology of Crimean-Congo Hemorrhagic Fever. Reviews of Infectious Diseases. 11(4), 794-800. https://doi.org/10.1093/clinids/11.supplement_4.s794.
  26. Trzeciak, S., Dellinger, R.P., Chansky, M.E., Arnold, R.C., Schorr, C., & Milcarek, B., et al. (2007). Serum lactate as a predictor of mortality in patients with infection. Intensive Care Medicine 33(6), 970–977. https://doi.org/10.1007/s00134-007-0563-9.
  27. Wang, B., Chen, G., Cao, Y., Xue, J., Li, J., & Wu, Y. (2015). Correlation of lactate/albumin ratio level to organ failure and mortality in severe sepsis and septic shock. Journal of Critical Care, 30(2), 271-275. https://doi.org/10.1016/j.jcrc.2014.10.030. Wang, R., He, M., Qu, F., Zhang, J., & Xu, J. (2022). Lactate Albumin Ratio Is Associated with Mortality in Patients with Moderate to Severe Traumatic Brain Injury. Front Neurol, 1, 13:662385. https://doi.org/10.3389/fneur.2022.662385. eCollection 2022.
  28. Kazan, F.G., & Sümer, H. (2019). Tokat il merkezinde Kırım Kongo kanamalı ateşi (KKKA) ön tanısıyla hastanede yatan hastaların, KKKA hastalığı hakkında bilgi düzeyi. Ankara Medical Journal, 19(2), 381-395. https://doi.org/10.17098/amj.576498.
  29. Shin, J., Hwang, S.Y., Jo, I.J.,, Kim, W.Y., Ryoo, S.M., & Kang, G.H., et al. (2018). Prognostic value of the lactate/albumin ratio for predicting 28-day mortality in critically ill sepsis patients. Shock, 50(5), 545–550.https://doi.org/10.1097/SHK.0000000000001128.