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Dergiler / Balıkesir Sağlık Bilimleri Dergisi / 2026 / Volume: 15 Issue: 3

Plasma-Treated Water And Olive Oil In DNCB-Induced Atopic Dermatitis Across Mouse Strains

Muhammed Demircioğlu(İstanbul Aydın Üniversitesi)0000-0001-8082-8630
Muhammet Bahaeddin Dörtbudak(HARRAN ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ)0000-0001-5777-964X
Büşra Söyler(SELÇUK ÜNİVERSİTESİ)0009-0006-9648-7029
Burak Dik(SELÇUK ÜNİVERSİTESİ)0000-0003-2738-6911
Sayfa
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Yayın Tarihi
2026-10-08
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Keywords: Atopic Dermatitis, Plasma Gases, Disease Models, Animal, Mice.

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Amaç & Hipotez:Abstract Objective: Atopic dermatitis (AD) is a clinically significant chronic inflammatory skin disorder in which disease severity and therapeutic response may vary across experimental animal strains.
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Temel Bulgular & Veri:This study aimed to investigate the sensitivities of BALB/c and Swiss Albino mice in the DNCB (2,4-dinitrochlorobenzene) -induced AD model and to evaluate the therapeutic efficacy of olive oil and water treated with cold atmospheric plasma.
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Sonuç & Katkı:Keywords: Atopic Dermatitis, Plasma Gases, Disease Models, Animal, Mice.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Atopic Dermatitis · Plasma Gases · Disease Models

Abstract

Abstract Objective: Atopic dermatitis (AD) is a clinically significant chronic inflammatory skin disorder in which disease severity and therapeutic response may vary across experimental animal strains. Cold atmospheric plasma (CAP) has recently emerged as a promising treatment modality due to its anti-inflammatory and tissue-repairing properties. This study aimed to investigate the sensitivities of BALB/c and Swiss Albino mice in the DNCB (2,4-dinitrochlorobenzene) -induced AD model and to evaluate the therapeutic efficacy of olive oil and water treated with cold atmospheric plasma. Materials and Methods: The experimental animals were divided into six groups: AD (BALB/c), AD+CAP Olive Oil (BALB/c), AD+CAP H₂O (BALB/c), AD (Swiss Albino), AD+CAP Olive Oil (Swiss Albino), and AD+CAP H₂O (Swiss Albino). Atopic dermatitis was induced using DNCB, and CAP-treated olive oil or CAP-treated water was applied as treatment. Histopathological and immunohistochemical analyses were performed to evaluate tissue changes and inflammatory responses. Results: Histopathological and immunohistochemical findings showed no significant strain-dependent differences between BALB/c and Swiss Albino mice in the DNCB-induced AD model. However, CAP-treated water produced a more pronounced therapeutic improvement compared with CAP-treated olive oil. Conclusion: CAP-treated water produced the clearest therapeutic response in both strains, while no statistically significant strain-dependent difference was detected. These findings suggest that CAP-treated water may be a promising approach for experimental AD. Keywords: Atopic Dermatitis, Plasma Gases, Disease Models, Animal, Mice.

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Bu Makaleye Atıf Yap

Demircioğlu, M., Dörtbudak, M. B., Söyler, B., Dik, B. (2026). Plasma-Treated Water And Olive Oil In DNCB-Induced Atopic Dermatitis Across Mouse Strains. Balıkesir Sağlık Bilimleri Dergisi, Volume: 15 Issue: 3. https://doi.org/10.53424/balikesirsbd.1989772

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