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Dergiler / Balıkesir Sağlık Bilimleri Dergisi / 2026 / Volume: 15 Issue: 3

Histopathological Patterns in Drug-Induced Liver Injury

Tevhide Bilgen Özcan(SBÜ Bağcılar Eğitim Araştırma Hastanesi)0000-0002-8098-960X
Sayfa
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Yayın Tarihi
2026-10-08
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

This study provides additional data on the histopathological spectrum of suspected DILI in a Turkish patient cohort.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: This study aimed to evaluate the histopathological findings and injury patterns in liver biopsies from patients with suspected drug-induced liver injury (DILI).
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Temel Bulgular & Veri:Results: Forty-five patients (71.4%) were female; mean age was 45.9±13.8 years.
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Sonuç & Katkı:This study provides additional data on the histopathological spectrum of suspected DILI in a Turkish patient cohort.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Drug-induced liver injury · hepatotoxicity · histopathology

Abstract

Objective: This study aimed to evaluate the histopathological findings and injury patterns in liver biopsies from patients with suspected drug-induced liver injury (DILI). Materials and Methods: Sixty-three patients undergoing core needle liver biopsy for suspected DILI were retrospectively reviewed. Biopsies were evaluated with H-E and special stains; HAI and fibrosis stage were scored using the Ishak system. Injury patterns were classified as hepatitic, cholestatic, centrilobular, AIH-like and mixed-type. Results: Forty-five patients (71.4%) were female; mean age was 45.9±13.8 years. Hepatitic-type injury was most frequent (68.3%), followed by mixed (17.5%), cholestatic (9.5%), centrilobular/Zone 3 (3.2%) and AIH-like types (1.6%). Mean HAI score was 8.1±2.4; fibrosis stage 2 was most common (42.9%). Eosinophilic infiltration was present in 81.0%, plasma cell infiltration was observed in 44.4% of cases. HAI score and fibrosis stage differed significantly among the three main injury-pattern groups (hepatitic, mixed and cholestatic) (p=0.015 and p=0.006, respectively). Conclusion: The histopathological spectrum of suspected DILI is heterogeneous. Eosinophilic infiltration and plasma cell infiltration are key diagnostic clues for clinicopathological correlation. This study provides additional data on the histopathological spectrum of suspected DILI in a Turkish patient cohort.

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Bu Makaleye Atıf Yap

Özcan, T. B. (2026). Histopathological Patterns in Drug-Induced Liver Injury. Balıkesir Sağlık Bilimleri Dergisi, Volume: 15 Issue: 3. https://doi.org/10.53424/balikesirsbd.1947986

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