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Dergiler / Aksaray University Journal of Sport and Health Researches / 2022 / Cilt: 3 Sayı: 2

Ailevi Akdeniz Ateşi Hakkında Bilinenler: Literatür Taraması

The Known About Familial Mediterranean Fever: Literature Review

Huseyin Erdal(Aksaray Üniversitesi,Tıp Fakültesi)0000-0003-0786-5077
Recep Eröz(AKSARAY ÜNİVERSİTESİ)0000-0003-0840-2613
Sayfa
145–155
Yayın Tarihi
2022-12-29
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Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bu derlemede, AAA üzerine son dönemde yapılmış olan çalışmaların ve elde edilen bulguların değerlendirlmesi amaçlanmıştır.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Kalıtsal otoinflamatuar hastalıkların en sık görüleni Ailevi Akdeniz Ateşidir (AAA).
📊
Temel Bulgular & Veri:Genellikle, AAA bağışıklık düzenlenmesinde yardımcı bir protein olan ve MEFV geninin fonksiyon mutasyonlarının kazanılmasından meydana gelmektedir.
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Sonuç & Katkı:Bu derlemede, AAA üzerine son dönemde yapılmış olan çalışmaların ve elde edilen bulguların değerlendirlmesi amaçlanmıştır.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:FMF · MEFV · Ailevi Akdeniz Ateşi

Özet

Kalıtsal otoinflamatuar hastalıkların en sık görüleni Ailevi Akdeniz Ateşidir (AAA). Genellikle, AAA bağışıklık düzenlenmesinde yardımcı bir protein olan ve MEFV geninin fonksiyon mutasyonlarının kazanılmasından meydana gelmektedir. Son yıllarda, gelişen teknolojik gelişmeler ile birlkte AAA tanısında, genetik testlerde ve tedavi uygulamalarında önemli ilerlemeler görülmektedir. Özellikle, yeni nesil dizeleme uygulamarı klinik açıdan önemli olan gen varyantlarının ortaya çıkmasına neden olmuştur. AAA, klinik olarak kısa ataklarla karakterize bir hastalık olarak görülse de, yapılan çalışmalarda kronik inflamatuar durum ile ilişkisi gösterilmiştir. AAA tedavisinde erken teşhis ve tedaviye olumlu yanıt hastaların iyileşme sürecinde oldukça önemlidir. Son yıllarda AAA hastalığı üzerine yapılan araştırmalar gittikçe artmaktadır. Bu derlemede, AAA üzerine son dönemde yapılmış olan çalışmaların ve elde edilen bulguların değerlendirlmesi amaçlanmıştır.

Abstract

The most common hereditary autoinflammatory disease is Familial Mediterranean Fever (FMF). Generally, FMF consists of acquiring function mutations of the MEFV gene, which is an auxiliary protein in immune regulation. In recent years, important advances have been seen in the diagnosis of FMF, genetic tests and treatment practices, together with the developing technological developments. In particular, new generation sequencing applications have led to the emergence of clinically important gene variants. Although FMF is clinically seen as a disease characterized by short attacks, studies have shown its relationship with a chronic inflammatory state. In the treatment of FMF, early diagnosis and positive response to treatment are very important in the recovery process of patients. In recent years, research on FMF has been increasing. In this review, it is aimed to evaluate the recent studies on FMF and the findings obtained.

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Bu Makaleye Atıf Yap

Erdal, H., Eröz, R. (2022). Ailevi Akdeniz Ateşi Hakkında Bilinenler: Literatür Taraması. Aksaray University Journal of Sport and Health Researches, Cilt: 3 Sayı: 2, 145–155. https://doi.org/10.54152/asujshr.1183793

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Kaynakça (58)

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