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Dergiler / Adıyaman Üniversitesi Sağlık Bilimleri Dergisi / 2026 / Cilt: 12 Sayı: 2

İyonize radyasyonun monoklonal antikorlar ile etkileşim parametrelerinin analizi: Teorik çalışma

Analysis of interaction parameters between ionizing radiation and monoclonal antibodies: A theoretical study

Halime Erzen Yıldız(VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ, VAN SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU)0000-0002-0603-1815
Berna Oto(VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ)0000-0003-4565-1790
Hamza Tunç(VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ)0000-0002-2787-8126
Sayfa
138–149
Yayın Tarihi
2026-08-20
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Bulgular: μ/ρ, Zeff ve Nel değerleri Compton saçılmasının baskın olduğu enerji bölgesinde azalırken, EBF ve EABF en yüksek değerlerine ulaştı.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amaç: EGFR hedefli monoklonal antikorların gama ışını zırhlama özelliklerini kütle zayıflatma katsayısı (μ/ρ), etkin atom numarası (Zeff), elektron yoğunluğu (Nel), maruziyet birikim faktörü (EBF) ve enerji soğurma birikim faktörü (EABF) açısından değerlendirmek.
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Temel Bulgular & Veri:Gereç ve Yöntem: Teorik μ/ρ değerleri WinXCom yazılımı ile hesaplandı.
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Sonuç & Katkı:Bulgular: μ/ρ, Zeff ve Nel değerleri Compton saçılmasının baskın olduğu enerji bölgesinde azalırken, EBF ve EABF en yüksek değerlerine ulaştı.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Monoklonal antikorlar · Radyasyon · Zayıflatma parametreleri

Özet

Amaç: EGFR hedefli monoklonal antikorların gama ışını zırhlama özelliklerini kütle zayıflatma katsayısı (μ/ρ), etkin atom numarası (Zeff), elektron yoğunluğu (Nel), maruziyet birikim faktörü (EBF) ve enerji soğurma birikim faktörü (EABF) açısından değerlendirmek. Gereç ve Yöntem: Teorik μ/ρ değerleri WinXCom yazılımı ile hesaplandı. Bu değerler kullanılarak farklı foton enerjileri ve ortalama serbest yol (mfp) değerleri için Zeff, Nel, EBF ve EABF belirlendi. Bulgular: μ/ρ, Zeff ve Nel değerleri Compton saçılmasının baskın olduğu enerji bölgesinde azalırken, EBF ve EABF en yüksek değerlerine ulaştı. Sonuç: Monoklonal antikorların gama ışını zırhlama özellikleri büyük ölçüde elementel bileşimleri, özellikle düşük atom numaralı elementlerin (C, H, N ve O) baskınlığı tarafından belirlenmektedir.

Abstract

Aim: To evaluate the gamma-ray shielding properties of EGFR-targeting monoclonal antibodies by determining the mass attenuation coefficient (μ/ρ), effective atomic number (Zeff), electron density (Nel), exposure buildup factor (EBF), and energy absorption buildup factor (EABF). Materials and Methods: Theoretical μ/ρ values were calculated using WinXCom software, and Zeff, Nel, EBF, and EABF were determined for different photon energies and mean free paths. Results: μ/ρ, Zeff, and Nel decreased in the Compton scattering region, while EBF and EABF reached their maximum values. Conclusion: The results indicate that the gamma-ray attenuation The gamma-ray shielding characteristics of monoclonal antibodies are primarily determined by their elemental composition, particularly the predominance of low atomic number elements (C, H, N, and O).

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Bu Makaleye Atıf Yap

Yıldız, H. E., Oto, B., Tunç, H. (2026). İyonize radyasyonun monoklonal antikorlar ile etkileşim parametrelerinin analizi: Teorik çalışma. Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, Cilt: 12 Sayı: 2, 138–149. https://doi.org/10.30569/adiyamansaglik.1870966

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