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Dergiler / Mühendislik Bilimleri ve Tasarım Dergisi / 2026 / Cilt: 14 Sayı: 3

PAPATYA İLE ZENGİNLEŞTİRİLMİŞ ÇOKLU YAĞ FORMÜLASYONLARI: KİMYASAL PROFİLLEME, MİKROBİYOLOJİK KALİTE VE IN VITRO SİTOTOKSİSİTE TARAMASI

CHAMOMILE-ENRICHED MULTI-OIL FORMULATIONS: CHEMICAL PROFILING, MICROBIOLOGICAL QUALITY AND IN VITRO CYTOTOXICITY SCREENING

Nebiye Özkara(ISPARTA UYGULAMALI BİLİMLER ÜNİVERSİTESİ)0009-0007-6076-1601
İkbal Demet Nane(ISPARTA UNIVERSITY OF APPLIED SCIENCES)0000-0002-3561-0322
Senem Akkoç(SÜLEYMAN DEMİREL ÜNİVERSİTESİ)0000-0002-1260-9425
Sayfa
783–793
Yayın Tarihi
2026-09-25
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Genel olarak sonuçlar, farklı kimyasal profillere sahip papatya kaynaklı bileşenlerin çoklu yağ sistemlerinde farklı formülasyon bileşenleri gibi davranabileceğini ve doğrudan birbirinin yerine kullanılabilir olarak değerlendirilmemesi gerektiğini göstermektedir.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Yağ bazlı formülasyonlarda kullanılan Matricaria chamomilla L. kaynaklı yağlar ve ekstraktlar; kaynak, üretim süreci ve ürün kalitesine bağlı olarak bileşim bakımından önemli farklılıklar gösterebilir.
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Temel Bulgular & Veri:Kimyasal bileşim GC–MS ile incelenmiş; formülasyonlar mikrobiyolojik kalite ve ön in vitro sitotoksisite açısından değerlendirilmiştir.
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Sonuç & Katkı:Genel olarak sonuçlar, farklı kimyasal profillere sahip papatya kaynaklı bileşenlerin çoklu yağ sistemlerinde farklı formülasyon bileşenleri gibi davranabileceğini ve doğrudan birbirinin yerine kullanılabilir olarak değerlendirilmemesi gerektiğini göstermektedir.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Matricaria chamomilla L. · Süperkritik CO₂ Ekstraksiyonu · GC–MS

Özet

Yağ bazlı formülasyonlarda kullanılan Matricaria chamomilla L. kaynaklı yağlar ve ekstraktlar; kaynak, üretim süreci ve ürün kalitesine bağlı olarak bileşim bakımından önemli farklılıklar gösterebilir. Bu çalışmada, süperkritik CO₂ papatya ekstraktı ve ticari papatya yağı, aynı baz matriks kullanılarak hazırlanan model çoklu yağ formülasyonlarına dahil edilmiştir. Formülasyonlar arasında değiştirilen tek değişken papatya kaynaklı bileşen olmuştur. Kimyasal bileşim GC–MS ile incelenmiş; formülasyonlar mikrobiyolojik kalite ve ön in vitro sitotoksisite açısından değerlendirilmiştir. Süperkritik CO₂ ekstraktı başlıca bisabolol oksit A (%47,26) ve trans-en-in-disikloeter, diğer adıyla trans-spiroeter (%32,70), ile karakterize edilmiştir. Ticari yağ ise β-farnesen bakımından zengin bir profil göstermiş; başlıca bileşenleri β-farnesen (%49,05), trans-α-farnesen (%7,85), bisabolol oksit (%7,24), bisabolol oksit A (%6,87), kamazulen (%6,11) ve germakren D (%5,61) olarak belirlenmiştir. Tüm formülasyonlar uygulanan mikrobiyolojik kalite kriterlerini karşılamıştır. Ön sitotoksisite taramasında IC₅₀ değerleri MDA-MB-231 hücrelerinde 3,386–6,302 µL/mL, HT-29 hücrelerinde ise >10 µL/mL olarak bulunmuştur. Genel olarak sonuçlar, farklı kimyasal profillere sahip papatya kaynaklı bileşenlerin çoklu yağ sistemlerinde farklı formülasyon bileşenleri gibi davranabileceğini ve doğrudan birbirinin yerine kullanılabilir olarak değerlendirilmemesi gerektiğini göstermektedir.

Abstract

Matricaria chamomilla L. oils and extracts used in oil-based formulations can differ considerably in composition depending on source, production process and product quality. In this study, a supercritical CO₂ chamomile extract and a commercial chamomile oil were incorporated into model multi-oil formulations prepared with the same base matrix. The chamomile-derived ingredient was the only variable changed between formulations. Chemical composition was examined by GC–MS, and the formulations were evaluated for microbiological quality and preliminary in vitro cytotoxicity. The supercritical CO₂ extract was mainly characterized by bisabolol oxide A (47.26%) and trans-en-in-dicycloether, also known as trans-spiroether (32.70%). The commercial oil showed a β-farnesene-rich profile, with β-farnesene (49.05%), trans-α-farnesene (7.85%), bisabolol oxide (7.24%), bisabolol oxide A (6.87%), chamazulene (6.11%) and germacrene D (5.61%) as the main constituents. All formulations complied with the applied microbiological quality criteria. Preliminary cytotoxicity screening gave IC₅₀ values of 3.386–6.302 µL/mL in MDA-MB-231 cells and >10 µL/mL in HT-29 cells. Overall, the results show that chamomile-derived ingredients with different chemical profiles may behave as distinct formulation components and should not be treated as directly interchangeable in multi-oil systems.

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Bu Makaleye Atıf Yap

Özkara, N., Nane, İ. D., Akkoç, S. (2026). PAPATYA İLE ZENGİNLEŞTİRİLMİŞ ÇOKLU YAĞ FORMÜLASYONLARI: KİMYASAL PROFİLLEME, MİKROBİYOLOJİK KALİTE VE IN VITRO SİTOTOKSİSİTE TARAMASI. Mühendislik Bilimleri ve Tasarım Dergisi, Cilt: 14 Sayı: 3, 783–793. https://doi.org/10.21923/jesd.1999849

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