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Dergiler / Journal of advances in vetbio science and techniques / 2026 / Issue: 2

Comparison of thiol/disulfide homeostasis in dogs diagnosed with infectious tracheobronchitis

Melek Aydemir Hökelekli(AKSARAY ÜNİVERSİTESİ)0000-0002-4732-8279
Selime Kübra Saka0009-0009-1577-4993
Ali Evren Haydardedeoğlu(AKSARAY ÜNİVERSİTESİ)0000-0002-8473-0072
İlker Camkerten(AKSARAY ÜNİVERSİTESİ)0000-0002-6952-7703
Hidayet Metin Erdoğan(AKSARAY ÜNİVERSİTESİ)0000-0003-1261-4352
Sayfa
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Yayın Tarihi
2026-05-07
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Further studies with a larger sample size and stratified by disease severity are required to clarify the role of thiol/disulphide parameters in the pathogenesis of ITB.

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Amaç & Hipotez:In this study, oxidative stress was assessed by comparing thiol/disulphide homeostasis between dogs diagnosed with infectious tracheobronchitis (ITB) (n = 15) and healthy controls (n = 15).
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Temel Bulgular & Veri:In healthy canines, the median values for TTL and NTL were 378 (320–470) µmol/L and 256 (216–421) µmol/L, respectively.
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Sonuç & Katkı:Further studies with a larger sample size and stratified by disease severity are required to clarify the role of thiol/disulphide parameters in the pathogenesis of ITB.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Infectious tracheobronchitis · dog · thiol/disulfide homeostasis

Abstract

In this study, oxidative stress was assessed by comparing thiol/disulphide homeostasis between dogs diagnosed with infectious tracheobronchitis (ITB) (n = 15) and healthy controls (n = 15). The levels of total thiol (TTL), native thiol (NTL), and disulphide in blood samples were measured using a spectrophotometric method. The disulphide/total thiol (DsTT), disulphide/native thiol (DsNTT), and native thiol/total thiol (NT/TT) ratios were calculated. In healthy canines, the median values for TTL and NTL were 378 (320–470) µmol/L and 256 (216–421) µmol/L, respectively. In ITB dogs, these values were 389 (139–490) µmol/L and 245.5 (102–382) µmol/L. Despite the presence of numerical disparities, no statistically significant variations were identified between the groups for any of the evaluated parameters using the Mann-Whitney U test (p > 0.05). These findings suggest that thiol/disulphide homeostasis remains relatively stable in ITB. Further studies with a larger sample size and stratified by disease severity are required to clarify the role of thiol/disulphide parameters in the pathogenesis of ITB.

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Bu Makaleye Atıf Yap

Hökelekli, M. A., Saka, S. K., Haydardedeoğlu, A. E., Camkerten, İ., Erdoğan, H. M. (2026). Comparison of thiol/disulfide homeostasis in dogs diagnosed with infectious tracheobronchitis. Journal of advances in vetbio science and techniques, Issue: 2. https://doi.org/10.31797/vetbio.1868841

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