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Dergiler / Journal of advances in vetbio science and techniques / 2026 / Issue: 2

Comparison of the effects of nano, micro silver particles, and silver nitrate on glioblastoma multiforme (CRL-1690)

Sinem Pehlivan(ANKARA MEDİPOL ÜNİVERSİTESİ)0000-0002-3389-3189
İlker Şimşek(ÇANKIRI KARATEKİN ÜNİVERSİTESİ)0000-0001-9181-9879
Eda Akdağ(CANKIRI KARATEKIN UNIVERSITY)0000-0001-9132-4438
Ali Fatih Yıltırak(CANKIRI KARATEKIN UNIVERSITY)0000-0001-9835-4584
Pınar Arslan Yüce(CANKIRI KARATEKIN UNIVERSITY)0000-0001-5910-2835
Özgür Kuzukıran(CANKIRI KARATEKIN UNIVERSITY)0000-0001-9294-2801
Ayhan Filazi(ANKARA UNIVERSITY, ANKARA FACULTY OF VETERINARY MEDICINE)0000-0002-2800-6215
Sayfa
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Yayın Tarihi
2026-05-06
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Although further research is needed regarding their ability to cross the blood-brain barrier, AgNPs can be considered as potential agents that can be effectively used in GBM treatment due to their potent inhibitory effects.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Glioblastoma multiforme (GBM) constitutes a significant majority of glial-derived tumors.
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Temel Bulgular & Veri:It has a poor prognosis.
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Sonuç & Katkı:Although further research is needed regarding their ability to cross the blood-brain barrier, AgNPs can be considered as potential agents that can be effectively used in GBM treatment due to their potent inhibitory effects.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Blood–brain barrier · Brain tumor treatment · Cytotoxicity

Abstract

Glioblastoma multiforme (GBM) constitutes a significant majority of glial-derived tumors. It has a poor prognosis. It is highly aggressive and malignant. In this disease, where treatment methods can be used alone or in combination, localization and, consequently, accessibility are among the most important factors affecting treatment. Nanoparticle-based approaches, such as silver-based nanoparticles containing different silver forms like AgNO₃, AgMP, and AgNP, are emerging as potential agents in tumor treatment. This study aimed to determine the effects of silver nanoparticles of different sizes on GBM cell viability. The results obtained revealed that AgNP exposure produced a highly cytotoxic effect and that the cytotoxic properties of AgMPs were lower compared to the other silver forms examined in our study. Although further research is needed regarding their ability to cross the blood-brain barrier, AgNPs can be considered as potential agents that can be effectively used in GBM treatment due to their potent inhibitory effects.

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Bu Makaleye Atıf Yap

Pehlivan, S., Şimşek, İ., Akdağ, E., Yıltırak, A. F., Yüce, P. A., Kuzukıran, Ö., Filazi, A. (2026). Comparison of the effects of nano, micro silver particles, and silver nitrate on glioblastoma multiforme (CRL-1690). Journal of advances in vetbio science and techniques, Issue: 2. https://doi.org/10.31797/vetbio.1863533

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