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Dergiler / Astım Allerji İmmünoloji / 2020 / Cilt: 18 - Sayı: 1

Role of Single Nucleotide Polymorphisms of Mammaglobin-A Gene in Nasal Polyposis: A Case Control Study

Işılay ÖZ
Selim Sermed ERBEK
Sibel ÖZDAŞ
Sibel BAŞTIMUR
Talih ÖZDAŞ
Sami Engin MUZ
Huntürk ATILLA
Kenan KURT
Sayfa
10–15
DOI
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Conclusion: MGA gene c38C> G, c.21C> T, c55 + 186G> A, and c.243 + 230A> T genotypes did not appear to be associated with susceptibility to NP with and without AR in our study population.

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Amaç & Hipotez:Objective: Nasal Polyposis (NP) is a chronic inflammatory disease and genetic factors play an important role in the pathophysiology.
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Temel Bulgular & Veri:Mammaglobin-A (MGA) gene expression was significantly higher in patients with NP and chronic rhinosinusitis compared to normal mucosa.
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Sonuç & Katkı:Conclusion: MGA gene c38C> G, c.21C> T, c55 + 186G> A, and c.243 + 230A> T genotypes did not appear to be associated with susceptibility to NP with and without AR in our study population.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objective: Nasal Polyposis (NP) is a chronic inflammatory disease and genetic factors play an important role in the pathophysiology. Mammaglobin-A (MGA) gene expression was significantly higher in patients with NP and chronic rhinosinusitis compared to normal mucosa. In the present study, we investigated the relationship between single nucleotide polymorphisms (SNPs) in the MGA gene and nasal polyposis in the Turkish population.Materials and Methods: A total of 87 patients diagnosed with NP and 60 healthy volunteers were enrolled in the study. Genotypes of MGA promoter SNPs c38C>G, c.21C >T, c55+186G>A and c.243+230A>T were determined by light SNP ASSAY after real time PCR analysis using genomic DNA samples obtained from the peripheral blood samples of all participants. Results: A total of 87 NP patients, 51 male and 36 female, with a mean age of 38.18±9.5 years were included in the study. No significant difference was determined at all positions c38C>G, c.21C >T, c55+186G>A and c.243+230A>T in nasal polyp patients compared to controls with and without allergic rhinitis (AR). Conclusion: MGA gene c38C> G, c.21C> T, c55 + 186G> A, and c.243 + 230A> T genotypes did not appear to be associated with susceptibility to NP with and without AR in our study population.

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Bu Makaleye Atıf Yap

ÖZ, I., ERBEK, S. S., ÖZDAŞ, S., BAŞTIMUR, S., ÖZDAŞ, T., MUZ, S. E., ATILLA, H., KURT, K. (2020). Role of Single Nucleotide Polymorphisms of Mammaglobin-A Gene in Nasal Polyposis: A Case Control Study. Astım Allerji İmmünoloji, Cilt: 18 - Sayı: 1, 10–15. https://ajindex.com/articles/141885

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Kaynakça (15)

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