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Dergiler / Acta Medica / 2020 / Cilt: 51 - Sayı: 2

Aquaporins: A Multidisciplinary Perspective on the Water Channel Proteins

Gokce ALP
Ipek BOSGELMEZ
Yesim OZTAS
Sayfa
30–42
DOI
—
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

This review investigates the properties and functions of the aquaporins in a multidisciplinary point of view and demonstrates the recent developments in aquaporin-based research.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Aquaporins are unique water channel proteins located at cell membranes that possess high water permeability and high solute rejection.
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Temel Bulgular & Veri:Their primary function is to maintain the osmotic balance of the cells via regulating the water transport.
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Sonuç & Katkı:This review investigates the properties and functions of the aquaporins in a multidisciplinary point of view and demonstrates the recent developments in aquaporin-based research.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Aquaporins are unique water channel proteins located at cell membranes that possess high water permeability and high solute rejection. Their primary function is to maintain the osmotic balance of the cells via regulating the water transport. However, their discovery had also provided the scientists to understand the pathophysiology of some diseases. In fact, aquaporins are shown to be strongly related to cancer by taking part in several tumor-related processes such as cell migration, cell proliferation and cell adhesion. Other than their functions in human body, recently, aquaporins have started to be used in engineering biomimetic membranes, for different applications such as desalination. This review investigates the properties and functions of the aquaporins in a multidisciplinary point of view and demonstrates the recent developments in aquaporin-based research.

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Bu Makaleye Atıf Yap

ALP, G., BOSGELMEZ, I., OZTAS, Y. (2020). Aquaporins: A Multidisciplinary Perspective on the Water Channel Proteins. Acta Medica, Cilt: 51 - Sayı: 2, 30–42. https://ajindex.com/articles/141616

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Kaynakça (16)

  1. Macey, R.L. and R.E.L. Farmer, Inhibition of water and solute permeability in human red cells. Biochimica et Biophysica Acta (BBA) - Biomembranes 1970; 211(1): 104-106
  2. Benga, G., et al., Water Permeability in Human-Erythrocytes - Identification of Membrane-Proteins Involved in Water Transport. European Journal of Cell Biology 1986; 41(2): 252-262
  3. Denker, B.M., et al., Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules. Journal of Biological Chemistry 1988; 263(30): 15634-42
  4. Preston, G.M., et al., Appearance of Water Channels in Xenopus Oocytes Expressing Red Cell CHIP28 Protein. Science 1992; 256(5055): 385-387
  5. Agre, P., et al., Aquaporin CHIP: the archetypal molecular water channel. American Journal of Physiology-Renal Physiology 1993; 265(4): F463-F476
  6. Agre, P., Aquaporin Water Channels (Nobel Lecture). Angewandte Chemie International Edition, 2004; 43(33): 4278-4290
  7. Verkman, A.S., M.O. Anderson, and M.C. Papadopoulos, Aquaporins: important but elusive drug targets. Nature Reviews Drug Discovery 2014; 13(4): 259-277
  8. Tesse, A., et al., Aquaporins as Targets of Dietary Bioactive Phytocompounds. Frontiers in Molecular Biosciences 2018; 5(30): 1-13
  9. Almasalmeh, A., et al., Structural determinants of the hydrogen peroxide permeability of aquaporins. The FEBS Journal 2014; 281(3): 647-656
  10. Verkman, A.S. and A.K. Mitra, Structure and function of aquaporin water channels. American Journal of Physiology-Renal Physiology 2000; 278(1): F13-F28
  11. King, L.S., D. Kozono, and P. Agre, From structure to disease: The evolving tale of aquaporin biology. Nature Reviews Molecular Cell Biology 2004; 5(9): 687-698
  12. Sui, H., et al., Structural basis of water-specific transport through the AQP1 water channel. Nature 2001; 414(6866): 872-878
  13. Murata, K., et al., Structural determinants of water permeation through aquaporin-1. Nature 2000; 407(6804): 599-605
  14. Papadopoulos, M.C. and S. Saadoun, Key roles of aquaporins in tumor biology. Biochimica et Biophysica Acta (BBA) - Biomembranes 2015; 1848(10, Part B): 2576-2583
  15. Pelagalli, A., et al., Aquaporins in Health and Disease: An Overview Focusing on the Gut of Different Species. International Journal of Molecular Sciences 2016; 17(8): 1213
  16. Kitchen, P., et al., Beyond water homeostasis: Diverse functional roles of mammalian aquaporins. Biochimica et Biophysica Acta