Dergiler / Anestezi Dergisi / 2020 / Cilt: 28 - Sayı: 1

Effectiveness of Dexmedetomidine for Controlled Hypotension in Providing Optimum Surgical Conditions for Functional Endoscopic Sinus Surgeries: A Double-Blinded Randomized Controlled Trial

Fonksiyonel Endoskopik Sinüs Cerrahilerinde Optimum Cerrahi Koşulları Sağlamada Kontrollü Hipotansiyon için Deksmedetomidinin Etkinliği: Çift Kör Randomize Kontrollü Çalışma

Sayfa
12–17
DOI
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Conclusion: Dexmedetomidine is an optimal effective agent that reduces blood loss by controlled hypotension during FESS providing ideal surgical field with better sedative and analgesic properties

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Amaç & Hipotez:Objective: Bleeding resulting in impaired intraoperative visibility and increased risk of injury to vital structures such as optic nerve and internal carotid artery requires effective control with controlled hypotension during functional endoscopic sinus surgeries.
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Temel Bulgular & Veri:Method: Ninety-two American Society of Anesthsiologists - ASA class I and II patients of comparable demographic profile, scheduled for elective FESS received either injectable dexmedetomidine (1 μk g hr-1) for the first 10 minutes and then 0.5 μ kg hr-1 as infusion (Group A) or equal volume of saline infusion (Group B).
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Sonuç & Katkı:Conclusion: Dexmedetomidine is an optimal effective agent that reduces blood loss by controlled hypotension during FESS providing ideal surgical field with better sedative and analgesic properties
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objective: Bleeding resulting in impaired intraoperative visibility and increased risk of injury to vital structures such as optic nerve and internal carotid artery requires effective control with controlled hypotension during functional endoscopic sinus surgeries. Our aim in this study is to assess the effectiveness of dexmedetomidine in reducing blood loss during functional endoscopic sinus surgeries (FESS) when it is used for controlled hypotension. Method: Ninety-two American Society of Anesthsiologists - ASA class I and II patients of comparable demographic profile, scheduled for elective FESS received either injectable dexmedetomidine (1 μk g hr-1) for the first 10 minutes and then 0.5 μ kg hr-1 as infusion (Group A) or equal volume of saline infusion (Group B). The hemodynamic changes, utilization of intraoperative rescue medication, intraoperative blood loss, emergence time, postoperative sedation and pain scores were recorded. Results: Patients in the dexmedetomidine group had a remarkable reduction in blood loss (p=0.000) with lesser intraoperative mean arterial blood pressure, heart rate, better sedation and pain scores postoperatively. The mean intraoperative rescue medication consumption was remarkably higher in patients of group B. Extubation time in group A patients was significantly higher (9.04 minutes) than in group B patients (5.07 minutes) (p=0.000). Conclusion: Dexmedetomidine is an optimal effective agent that reduces blood loss by controlled hypotension during FESS providing ideal surgical field with better sedative and analgesic properties

Abstract

Amaç: Fonksiyonel endoskopik sinüs cerrahileri sırasında, intraoperatif görüşte azalmaya ve optik sinir ve internal karotid arter gibi vital yapılarda hasar riskinde artmaya neden olan kanama, kontrollü hipotansiyon ile etkin kontrol gerektirir. Bu çalışmada amacımız, fonksiyonel endoskopik sinüs cerrahilerinde (FESS) deksmedetomidinin kontrollü hipotansiyon için kullanıldığında kan kaybını azaltmadaki etkinliğini değerlendirmektir. Yöntem: Elektif FESS planlanan, Amerikan Anesteziyologlar Derneği - ASA sınıf I ve II, demografik özellikler bakımından benzer 92 hasta, deksmedetomidin 1 μ kg sa-1 ilk 10 dk, sonrasında 0.5 μ kg sa-1 infüzyon (Grup A) veya eşit volümde salin infüzyonu aldı (Grup B). Hemodinamik değişiklikler, intraoperatif kurtarıcı ilaç tüketimi, intraoperatif kan kaybı, derlenme zamanı, postoperatif sedasyon ve ağrı skorları kaydedildi. Bulgular: Deksmedetomidin grubundaki hastalarda, daha düşük intraoperatif ortalama arteriyel kan basıncı, kalp hızı, postoperatif daha iyi sedasyon ve ağrı skorları ile birlikte kan kaybında (p=0.000) belirgin bir azalma vardı. Ortalama intraoperatif kurtarıcı ilaç tüketimi B grubundaki hastalarda belirgin olarak daha yüksekti. A grubundaki hastalarda ekstübasyon süresi (9.04 dk), B grubundaki hastalara göre anlamlı olarak yüksekti (5.07 dk) (p=0.000). Sonuç: Deksmedetomidin, FESS sırasında kontrollü hipotansiyon ile kan kaybını azaltan, daha iyi sedatif ve analjezik özellikler ile ideal cerrahi alan sağlayan optimal etkili bir ajandır.

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Bu Makaleye Atıf Yap

NEETHİRAJAN, S. G. R., CHANDRASEKARAN, N., PARAMESWARİ, A. (2020). Effectiveness of Dexmedetomidine for Controlled Hypotension in Providing Optimum Surgical Conditions for Functional Endoscopic Sinus Surgeries: A Double-Blinded Randomized Controlled Trial. Anestezi Dergisi, Cilt: 28 - Sayı: 1, 12–17. https://ajindex.com/articles/141495

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Kaynakça (12)

  1. Cincikas D, Ivaskevicius J. Application of controlled arterial hypotension in endoscopic rhinosurgery. Medicina. 2003;39:852-9
  2. Testa LD, Tobias JD. Pharmacologic drugs for controlled hypotension. J Clin Anesth. 1995;7:326-37.
  3. Degoute CS. Controlled hypotension: a guide to drug choice. Drugs. 2007;67:1053-76.
  4. Simpson P. Perioperative blood loss and its reduction: the role of the anaesthetist. Br J Anaesth. 1992;69:498- 507.
  5. Richa F, Yazigi A, Sleilaty G, Yazbeck P. Comparison between dexmedetomidine and remifentanil for controlled hypotension during tympanoplasty. Eur J Anaesthesiol. 2008;25:369-74.
  6. Ayoglu H, Yapakci O, Ugur MB et al. Effectiveness of dexmedetomidine in reducing bleeding during septoplasty and tympanoplasty operations. J Clin Anesth. 2008;20:437-41.
  7. Ulger MH, Demirbilek S, Koroglu A, Borazan H, Erosy MO. Orta kulak cerrahisinde dekmedetomidin ile kontrolie hipotansiyon. Inonu Uni Tip Kak Derg. 2004;11:237- 41
  8. Soliman R, Fouad E. The effects of dexmedetomidine and magnesium sulphate in adult patients undergoing endoscopic transnasal transsphenoidal resection of pituitary adenoma: A double-blind randomised study. Indian J Anaesth. 2017;61:410-7.
  9. Goksu S, Arik H, Demiryurek S, Mumbuc S, Oner U, Demiryurek AT. Effects of dexmedetomidine infusion in patients undergoing functional endoscopic sinus surgery under local anesthesia. Eur J Anaesthesiol. 2008;25:22-8.
  10. Gousheh S, Olapour A, Nesioonpour S, Rashidi M, Pooyan S. The Effect of Intravenous Infusion of Dexmedetomidine to Prevent Bleeding During Functional Endoscopic Sinus Surgery: A Clinical Trial. Anesthesiology and Pain Medicine. 2017;7.
  11. Karabayirli S, Ugur KS, Demircioglu RI et al. Surgical conditions during FESS; comparison of dexmedetomidine and remifentanil. Eur Arch Otorhinolaryngol. 2017;274:239-45.
  12. Bajwa SJ, Kaur J, Kulshrestha A, Haldar R, Sethi R, Singh A. Nitroglycerine, esmolol and dexmedetomidine for induced hypotension during functional endoscopic sinus surgery: A comparative evaluation. J Anaesthesiol Clin Pharmacol. 2016;32:192-7. https://doi.org/10.4103/0970-9185.