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Dergiler / Çukurova Anestezi ve Cerrahi Bilimler Dergisi / 2026 / Cilt: 4 Sayı: 1

Lynch sendromunda profilaktik cerrahi: Ne zaman ve nasıl?– Güncel yaklaşımlar ve literatür derlemesi

Emrah Akın(Sakarya University Educational and Research Hospital)0000-0003-0224-3834
Uğur Can Dülger(Sakarya Üniversitesi Eğitim ve Araştırma Hastanesi)0000-0001-5476-715X
Fatih Altıntoprak(Sakarya Üniversitesi Tıp Fakültesi)0000-0002-3939-8293
Sayfa
37–44
Yayın Tarihi
2021-04-30
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Sendromun tanısı klinik bulgular, patolojik özellikler, aile öyküsü ve genetik testler ile koyulabilir.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Lynch sendromu; kolorektal kansere dönüşen soliter adenomlar ve ekstra-kolonik manifestasyonlarla karakterize, otozomal dominant kalıtımlı bir kanser predispozan sendromdur.
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Temel Bulgular & Veri:Sendromun tanısı klinik bulgular, patolojik özellikler, aile öyküsü ve genetik testler ile koyulabilir.
💡
Sonuç & Katkı:Lynch Sendromu riski altında olan bireylerde tarama çalışmalarına 20’ li yaşlardan itibaren başlanmalı, mutasyon pozitif taşıyıcılarında yıllık olarak devam edilmeli ve belli şartların varlığında da da profilaktik cerrahi gündeme alınmalıdır.
🔬Tür:Derleme
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:LYNCH sendromu · Herediter polipozis sendromu · Profilaktik cerrahi

Özet

Lynch sendromu; kolorektal kansere dönüşen soliter adenomlar ve ekstra-kolonik manifestasyonlarla karakterize, otozomal dominant kalıtımlı bir kanser predispozan sendromdur. Sendromun tanısı klinik bulgular, patolojik özellikler, aile öyküsü ve genetik testler ile koyulabilir. Lynch Sendromu riski altında olan bireylerde tarama çalışmalarına 20’ li yaşlardan itibaren başlanmalı, mutasyon pozitif taşıyıcılarında yıllık olarak devam edilmeli ve belli şartların varlığında da da profilaktik cerrahi gündeme alınmalıdır.

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Bu Makaleye Atıf Yap

Akın, E., Dülger, U. C., Altıntoprak, F. (2021). Lynch sendromunda profilaktik cerrahi: Ne zaman ve nasıl?– Güncel yaklaşımlar ve literatür derlemesi. Çukurova Anestezi ve Cerrahi Bilimler Dergisi, Cilt: 4 Sayı: 1, 37–44. https://ajindex.com/articles/1380065

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