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Dergiler / Çukurova Anestezi ve Cerrahi Bilimler Dergisi / 2026 / Cilt: 7 Sayı: 3

Effects of Curcumin and Doxorubicin on the Viability of Neuroblastoma Cancer Cell Line

İlker Ünlü(Beykent University, Faculty of Medicine, Department of Neurosurgery)0000-0003-4320-8381
İlhan Özdemir(Private Buhara Hospital)0000-0001-9957-0211
Şamil Öztürk(Çanakkale Onsekiz Mart University, Vocational School of Health Services)0000-0002-9435-8139
M. Cudi Tuncer(Diyarbakır Dicle University, Faculty of Medicine)0000-0001-7317-5467
Sayfa
191–194
Yayın Tarihi
2024-09-30
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: These results showed that Cur could be an alternative agent in the treatment of neuroblastoma, and its fewer side effects compared to other chemotherapeutic agents such as Dox would increase its preferability.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Aim: Neuroblastoma has a very important place among childhood diseases, and despite all the methods used in treatment, it is very difficult to prevent neuroblastoma invasion.
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Temel Bulgular & Veri:In this study, the anticancer activities of curcumin (Cur), one of the important active compounds, were demonstrated in the Neuroblastoma cancer cell line (Na2B).
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Sonuç & Katkı:Conclusion: These results showed that Cur could be an alternative agent in the treatment of neuroblastoma, and its fewer side effects compared to other chemotherapeutic agents such as Dox would increase its preferability.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Neuroblastoma · Na2B cell line · cancer

Abstract

Aim: Neuroblastoma has a very important place among childhood diseases, and despite all the methods used in treatment, it is very difficult to prevent neuroblastoma invasion. The number of studies showing that curcumin, the most active component of turmeric, is not toxic, is increasing day by day. In this study, the anticancer activities of curcumin (Cur), one of the important active compounds, were demonstrated in the Neuroblastoma cancer cell line (Na2B). Method: Neuroblastoma cell line was used in the study. To determine the IC50 doses of Dox and Cur, Na2B cells line were cultivated with an automatic pipette. MTT analysis was performed to analyze cell survival (viability). Inhibition levels in the cells were determined at 24 and 48 hours. Results: While the IC50 of Na2B cell proliferation was approximately 124.5 uM at the 48th hour in Dox-treated cells, the IC50 value of Cur at the 48th hour was found to be 224.6 uM. Conclusion: These results showed that Cur could be an alternative agent in the treatment of neuroblastoma, and its fewer side effects compared to other chemotherapeutic agents such as Dox would increase its preferability.

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Bu Makaleye Atıf Yap

Ünlü, İ., Özdemir, İ., Öztürk, Ş., Tuncer, M. C. (2024). Effects of Curcumin and Doxorubicin on the Viability of Neuroblastoma Cancer Cell Line. Çukurova Anestezi ve Cerrahi Bilimler Dergisi, Cilt: 7 Sayı: 3, 191–194. https://doi.org/10.36516/jocass.1520583

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