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Dergiler / Bozok Tıp Dergisi / 2026 / Cilt: 16 Sayı: 3

Unipolar ve Bipolar Depresyonda İnflamatuar ve Metabolik Parametrelerin Karşılaştırılması

COMPARISON OF INFLAMMATORY AND METABOLIC PARAMETERS IN UNIPOLAR AND BIPOLAR DEPRESSION

Mehmet Murat Kırpınar(İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, CERRAHPAŞA TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, RUH SAĞLIĞI VE HASTALIKLARI ANABİLİM DALI)0000-0003-0456-8333
İrem Yıldırım(İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, CERRAHPAŞA TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, RUH SAĞLIĞI VE HASTALIKLARI ANABİLİM DALI)
Sarp Yoldaş(İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, CERRAHPAŞA TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, RUH SAĞLIĞI VE HASTALIKLARI ANABİLİM DALI)0009-0008-3196-7165
Furkan Toksoy(İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, CERRAHPAŞA TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, RUH SAĞLIĞI VE HASTALIKLARI ANABİLİM DALI)
Merve Rana Altunel(İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, CERRAHPAŞA TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, RUH SAĞLIĞI VE HASTALIKLARI ANABİLİM DALI)0009-0001-0244-2967
Zeynep Özge Dağoğlu(İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, CERRAHPAŞA TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, RUH SAĞLIĞI VE HASTALIKLARI ANABİLİM DALI)0009-0005-7396-1253
Ömer Faruk Demirel(İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, CERRAHPAŞA TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, RUH SAĞLIĞI VE HASTALIKLARI ANABİLİM DALI)0000-0003-3012-1252
Cana Aksoy Poyraz(İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, CERRAHPAŞA TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, RUH SAĞLIĞI VE HASTALIKLARI ANABİLİM DALI)0000-0001-9026-0444
Sayfa
355–368
Yayın Tarihi
2026-09-25
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bulgular: BPD grubunda nötrofil sayısı ve TyG indeksi UPD grubuna kıyasla anlamlı düzeyde yüksek bulunmuştur.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amaç: Unipolar depresyon (UPD) ve bipolar depresyonun (BPD) klinik olarak ayırt edilmesi güç olabilmektedir.
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Temel Bulgular & Veri:Bu çalışmada, yatan hastalarda UPD, BPD ve bipolar mani (BPM) grupları arasında inflamatuar ve metabolik parametrelerin karşılaştırılması ve UPD ile BPD arasındaki olası biyolojik farklılıkların değerlendirilmesi amaçlanmıştır.
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Sonuç & Katkı:Bulgular: BPD grubunda nötrofil sayısı ve TyG indeksi UPD grubuna kıyasla anlamlı düzeyde yüksek bulunmuştur.
🔬Tür:Araştırma Makalesi
📍Kapsam:399 hasta
⚙️Değişkenler:Bipolar Bozukluk · Majör Depresif Bozukluk · İnflamasyon

Özet

Amaç: Unipolar depresyon (UPD) ve bipolar depresyonun (BPD) klinik olarak ayırt edilmesi güç olabilmektedir. Bu çalışmada, yatan hastalarda UPD, BPD ve bipolar mani (BPM) grupları arasında inflamatuar ve metabolik parametrelerin karşılaştırılması ve UPD ile BPD arasındaki olası biyolojik farklılıkların değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: Bu retrospektif çalışmaya, bir üniversite hastanesinde ICD-10 tanı kriterlerine göre Depresif Epizod (F32) veya Bipolar Bozukluk (F31) tanısı ile yatarak takip edilen 399 hasta dahil edilmiştir. Hematolojik, inflamatuar (lökosit, nötrofil, C-reaktif protein, ferritin) ve metabolik parametreler [açlık glukozu, lipid profili, Trigliseridler (TyG) indeksi] retrospektif olarak değerlendirilmiştir. Gruplar arası karşılaştırmalar uygun parametrik ve non-parametrik testler ile yapılmış; yaş, cinsiyet ve hastaneye yatış sayısı için düzeltme amacıyla kovaryans analizi (ANCOVA) uygulanmıştır. Bulgular: BPD grubunda nötrofil sayısı ve TyG indeksi UPD grubuna kıyasla anlamlı düzeyde yüksek bulunmuştur. Metabolik parametreler açısından üç grup arasında anlamlı farklılıklar saptanmış; özellikle BPD grubunda daha olumsuz bir metabolik profil gözlenmiştir. Yaş, cinsiyet ve yatış sayısı için düzeltme yapıldıktan sonra nötrofil sayısı ve bazı metabolik parametrelerdeki farkların anlamlılığını koruduğu, diğer inflamatuar belirteçlerin ise tanı gruplarıyla tutarlı bir ilişki göstermediği izlenmiştir. Ferritin düzeyleri açısından gruplar arasında anlamlı bir fark izlenmemiştir. Sonuç: Bulgular, unipolar ve BPD arasında inflamatuar ve metabolik özellikler açısından biyolojik heterojeniteye işaret etmektedir. Ancak gruplar arasında önemli ölçüde örtüşme bulunması nedeniyle, bu parametreler tanısal belirteçler olarak değil, klinik değerlendirmeyi destekleyici biyolojik göstergeler olarak yorumlanmalıdır.

Abstract

Objective: Differentiating bipolar depression (BPD) from unipolar depression (UPD) remains a clinical challenge. This study aimed to compare inflammatory and metabolic parameters among hospitalized patients with UPD, BPD, and bipolar mania (BPM), and to evaluate potential biological differences between UPD and BPD. Material and Methods: This retrospective study included 399 inpatients diagnosed with Depressive Episode (F32) or Bipolar Disorder (F31) according to ICD-10 criteria at a tertiary university hospital. Hematological, inflammatory (white blood cell count, neutrophil count, C-reactive protein, ferritin), and metabolic parameters [fasting glucose, lipid profile, Triglycerides (TyG) index] were retrospectively analyzed. Group comparisons were performed using appropriate parametric and non-parametric tests. Analyses of covariance (ANCOVA) were conducted to adjust for age, sex, and number of hospitalizations. Results: Neutrophil counts and TyG index values were significantly higher in the BPD group compared with the UPD group. Significant differences in metabolic parameters were observed across the three groups, with a less favorable metabolic profile particularly evident in BPD. After adjustment for age, sex, and hospitalization frequency, neutrophil counts and several metabolic parameters remained significantly different between groups, whereas other inflammatory markers were not consistently associated with diagnostic group. Ferritin levels did not differ significantly between groups. Conclusion: These findings suggest biological heterogeneity between unipolar and BPD in terms of inflammatory and metabolic characteristics. However, given the substantial overlap between groups, these parameters should be interpreted as supportive biological correlates rather than diagnostic markers.

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Bu Makaleye Atıf Yap

Kırpınar, M. M., Yıldırım, İ., Yoldaş, S., Toksoy, F., Altunel, M. R., Dağoğlu, Z. Ö., Demirel, Ö. F., Poyraz, C. A. (2026). Unipolar ve Bipolar Depresyonda İnflamatuar ve Metabolik Parametrelerin Karşılaştırılması. Bozok Tıp Dergisi, Cilt: 16 Sayı: 3, 355–368. https://doi.org/10.16919/bozoktip.1871825

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