Dergiler / Batı Karadeniz Tıp Dergisi / 2026 / Cilt: 10 Sayı: 1

Epilepsili çocuklarda duyusal algı profilleri: Prospektif kontrollü bir çalışma

Sensory perception profiles in children with epilepsy: A prospective controlled study

Seda Ayaz Taş(Department of Physiotherapy and Rehabilitation, Bolu Abant İzzet Baysal University, Faculty of Health Sciences, Bolu, Türkiye)0000-0002-2778-0065
Merve Başol Göksülük(Department of Biostatistics, Sakarya University, Faculty of Medicine, Sakarya, Türkiye)0000-0002-2223-7856
Özge Karanlık Özcan(Department of Physiotherapy and Rehabilitation, Bolu Abant İzzet Baysal University, Faculty of Health Sciences, Bolu, Türkiye)0000-0003-0308-4281
Seda Yakıt Yeşilyurt(Department of Physiotherapy and Rehabilitation, İzmir University of Economics, Faculty of Health Sciences, İzmir, Türkiye)0000-0002-2522-6474
Sedef Kestellioğlu(Department of Pediatrics, Bolu Abant İzzet Baysal University, Faculty of Medicine, Bolu, Türkiye)0009-0008-8786-2004
Sezen Tezcan(Department of Physiotherapy and Rehabilitation, Bolu Abant İzzet Baysal University, Faculty of Health Sciences, Bolu, Türkiye)0000-0003-4046-9201
Ayşegül Danış(Department of Pediatric Neurology, Bolu Abant İzzet Baysal University, Faculty of Medicine, Bolu, Türkiye)0000-0003-0962-2116
Sayfa
122–132
Yayın Tarihi
2026-03-26
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bulgular: Epilepsili çocuklar ile kontroller arasında toplam duyusal işlemleme skorlarında anlamlı fark saptanmamıştır (p>0.05).

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Amaç: Epilepsi, gelişmekte olan beynin işlevsel organizasyonunu bozan ve yalnızca tekrarlayan nöbetlerle sınırlı kalmayıp bilişsel ve duyusal süreçleri de etkileyen kronik bir nörolojik bozukluktur.
📊
Temel Bulgular & Veri:Bu çalışma, epilepsili çocukların duyusal algı profillerini tipik gelişen akranlarıyla karşılaştırarak epilepsinin duyusal algı süreçleri üzerindeki etkisini ortaya koymayı amaçlamaktadır.
💡
Sonuç & Katkı:Bulgular: Epilepsili çocuklar ile kontroller arasında toplam duyusal işlemleme skorlarında anlamlı fark saptanmamıştır (p>0.05).
🔬Tür:Uygulamalı Anket & Alan Araştırması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Algı · antiepileptik ilaçlar · çocuklar

Özet

Amaç: Epilepsi, gelişmekte olan beynin işlevsel organizasyonunu bozan ve yalnızca tekrarlayan nöbetlerle sınırlı kalmayıp bilişsel ve duyusal süreçleri de etkileyen kronik bir nörolojik bozukluktur. Bu çalışma, epilepsili çocukların duyusal algı profillerini tipik gelişen akranlarıyla karşılaştırarak epilepsinin duyusal algı süreçleri üzerindeki etkisini ortaya koymayı amaçlamaktadır. Gereç ve Yöntemler: Bu prospektif kontrollü çalışmada örneklem büyüklüğü ön güç analizine dayalı olarak belirlenmiş; 5-12 yaş aralığında, kolayda örnekleme yöntemiyle seçilen toplam 49 çocuk (25 epilepsi tanılı, 24 tipik gelişen kontrol) çalışmaya dahil edildi. Katılımcılardan demografik ve klinik veriler toplandı; duyusal algı, Duyusal İşleme Ölçeği-Ev Formu’nun Türkçe geçerli-güvenilir versiyonuyla değerlendirildi. Ölçek; sosyal katılım, görme, işitme, dokunma, tat-koku, vücut farkındalığı, denge-hareket ve planlama alanlarını içermektedir. Grup farkları, karıştırıcılar için düzeltilerek uygun istatistiksel yöntemlerle analiz edildi. Bulgular: Epilepsili çocuklar ile kontroller arasında toplam duyusal işlemleme skorlarında anlamlı fark saptanmamıştır (p>0.05). Tat ve koku algısındaki zayıflık artmış vücut kitle indeksi ile ilişkili bulunmuştur (p=0.010). Duyusal profillerin; yapısal beyin farklılıkları, ilaç kullanımı ve nöbet zamanlaması gibi klinik alt bileşenlerden etkilendiği saptanmıştır. Bulgular, klinik faktörlere göre şekillenen heterojen bir duyusal yapıya işaret etmektedir. Sonuç: Çocukluk çağı epilepsisinde duyusal işlemleme ve algı, tanıdan ziyade yapısal, metabolik ve klinik değişkenlerden etkilenmektedir. Klinik yönetimde bu parametreleri dikkate alan bireyselleştirilmiş stratejilerin benimsenmesi önerilmektedir.

Abstract

Aim: Epilepsy is a chronic neurological disorder that disrupts the functional organization of the developing brain, with consequences extending beyond recurrent seizures to cognitive and sensory processes. This study aims to elucidate the effects of epilepsy on sensory perception by comparing the sensory profiles of children with epilepsy to those of their typically developing peers. Material and Methods: In this a prospective controlled study, the sample size was determined based on an a priori power analysis, and a total of 49 children aged 5-12 years (25 with epilepsy and 24 typically developing controls), selected using convenience sampling, were included in the study. Demographic and clinical data were collected from the participants, and sensory perception was evaluated using the validated Turkish version of the Sensory Processing Measure-Home Form. The scale comprises the domains of social participation, vision, hearing, touch, taste and smell, body awareness, balance and motion, and planning and ideas. Group differences were analyzed using appropriate statistical methods with adjustments for potential confounders. Results: No significant differences were observed between children with epilepsy and healthy controls in total sensory processing scores (p>0.05). Deficits in taste and smell perception were significantly associated with an increased body mass index (p=0.010). Sensory profiles were found to be primarily influenced by clinical sub-components, including structural brain abnormalities, antiepileptic drug use, and seizure timing. These findings indicate a heterogeneous sensory structure shaped by specific clinical and metabolic determinants. Conclusion: Sensory processing and perception in pediatric epilepsy are influenced by structural, metabolic, and clinical variables rather than the diagnosis alone. It is recommended that individualized strategies considering these parameters be adopted in clinical management.

🔖

Bu Makaleye Atıf Yap

Taş, S. A., Göksülük, M. B., Özcan, Ö. K., Yeşilyurt, S. Y., Kestellioğlu, S., Tezcan, S., Danış, A. (2026). Epilepsili çocuklarda duyusal algı profilleri: Prospektif kontrollü bir çalışma. Batı Karadeniz Tıp Dergisi, Cilt: 10 Sayı: 1, 122–132. https://doi.org/10.29058/mjwbs.1798429

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (46)

  1. Green JL, dos Santos WF, Fontana ACC. Role of glutamate excitotoxicity and glutamate transporter EAAT2 in epilepsy: opportunities for novel therapeutics development. Biochem Pharmacol. 2021;193:114786. https://doi.org/10.1016/j.bcp.2021.114786
  2. Boison D, Steinhäuser C. Epilepsy and astrocyte energy metabolism. Glia. 2018;66(6):1235-1243. https://doi.org/10.1002/glia.23247
  3. Anwar H, Khan QU, Nadeem N, Pervaiz I, Ali M, Cheema FF. Epileptic seizures. Discoveries (Craiova). 2020;8(2):e110. https://doi.org/10.15190/d.2020.7
  4. Wu J, Hu D, Zheng R, Jiang T, Gao F, Cao J. Information flow-based brain network analysis of healthy and epileptic syndromes in children. IEEE Sens J. 2024;24(12):19417-19427. https://doi.org/10.1109/JSEN.2024.3394046
  5. Feng X, Piper RJ, Prentice F, Clayden JD, Baldeweg T. Functional brain connectivity in children with focal epilepsy: a systematic review of functional MRI studies. Seizure. 2024;117:164-173. https://doi.org/10.1016/j.seizure.2024.03.014
  6. Stenroos P, Guillemain I, Tesler F, Montigon O, Collomb N, Stupar V, et al. EEG-fMRI in awake rats and whole-brain simulations show decreased brain responsiveness to sensory stimulations during absence seizures. eLife. 2024;12:e90318. https://doi.org/10.7554/eLife.90318
  7. Panarese A, Vissani M, Meneghetti N, Vannini E, Cracchiolo M, Micera S, et al. Disruption of layer-specific visual processing in a model of focal neocortical epilepsy. Cereb Cortex. 2023;33(7):4173-4187. https://doi.org/10.1093/cercor/bhac335
  8. Studer F, Laghouati E, Jarre G, David O, Pouyatos B, Depaulis A. Sensory coding is impaired in rat absence epilepsy. J Physiol. 2019;597(3):951-966. https://doi.org/10.1113/JP277117
  9. Rodríguez-Armendariz E, Vela-Romero M, Galiana A. Sensory processing challenges in children with neurodevelopmental disorders and genetic conditions: an observational study. NeuroSci. 2024;5(3):339-353. https://doi.org/10.3390/neurosci5030023
  10. Gigliotti F, Giovannone F, Belli A, Sogos C. Atypical sensory processing in neurodevelopmental disorders: clinical phenotypes in preschool-aged children. Children (Basel). 2024;11(7):875. https://doi.org/10.3390/children11070875
  11. Galiana-Simal A, Vela-Romero M, Romero-Vela VM, Oliver-Tercero N, García-Olmo V, Benito-Castellanos PJ, et al. Sensory processing disorder: key points of a frequent alteration in neurodevelopmental disorders. Cogent Med. 2020;7(1):1787680. https://doi.org/10.1080/2331205X.2020.1787680
  12. Cascio CJ. Somatosensory processing in neurodevelopmental disorders. J Neurodev Disord. 2010;2(2):62-69. https://doi.org/10.1007/s11689-010-9046-3
  13. Monaco S, Malfatti G, Culham JC, Cattaneo L, Turella L. Decoding motor imagery and action planning in the early visual cortex. Neuroimage. 2020;218:116972. https://doi.org/10.1016/j.neuroimage.2020.116972
  14. Alkhlouf AM, Che Omar M, Kazakzeh M. The role of early intervention in developing auditory perception skills in first-stage children. Int J Acad Res Bus Soc Sci. 2025;15(3):1100-1106. https://doi.org/10.6007/IJARBSS/v15-i3/22643
  15. Liu P, Zhou J, Zhang L, Ji H, Xu J, Xu Q, et al. A longitudinal study on auditory processing development in preschool children with autism spectrum disorder: study protocol. BMC Psychiatry. 2024;24:723. https://doi.org/10.1186/s12888-024-06086-3
  16. Lackner JR, DiZio P. Vestibular, proprioceptive, and haptic contributions to spatial orientation. Annu Rev Psychol. 2005;56:115-147. https://doi.org/10.1146/annurev.psych.55.090902.142023
  17. Cullen KE. Vestibular processing during natural self-motion: implications for perception and action. Nat Rev Neurosci. 2019;20:346-363. https://doi.org/10.1038/s41583-019-0153-1
  18. Loureiro M, Achargui R, Flakowski J, Van Zessen R, Stefanelli T, Pascoli V, et al. Social transmission of food safety depends on synaptic plasticity in the prefrontal cortex. Science. 2024;384:eadh1234. https://doi.org/10.1126/science.adh1234
  19. Wu B, Eldeghaidy S, Ayed C, Fisk ID, Hewson L, Liu Y. Mechanisms of umami taste perception: from molecular level to brain imaging. Crit Rev Food Sci Nutr. 2022;62:7015-7024. https://doi.org/10.1080/10408398.2021.1902175
  20. Boesveldt S, Parma V. The importance of the olfactory system in human well-being, through nutrition and social behavior. Cell Tissue Res. 2021;383:559-567. https://doi.org/10.1007/s00441-020-03367-7
  21. Ianov Vitanov R, Achterberg J, Akarca D, Astle DE, Baker K. Synaptic function and sensory processing in ZDHHC9-associated neurodevelopmental disorder: a mechanistic account. bioRxiv. 2024. https://doi.org/10.1101/2024.03.28.587155
  22. Bozzi Y, Casarosa S, Caleo M. Epilepsy as a neurodevelopmental disorder. Front Psychiatry. 2012;3:19. https://doi.org/10.3389/fpsyt.2012.00019
  23. Lobato-Ruiz V, Romero-Ayuso D, Toledano-González A, Triviño-Juárez JM. Quality of life and parental stress related to executive functioning, sensory processing, and activities of daily living in children and adolescents with neurodevelopmental disorders. PeerJ. 2025;13:e19326. https://doi.org/10.7717/peerj.19326
  24. Hornix BE, Havekes R, Kas MJH. Multisensory cortical processing and dysfunction across the neuropsychiatric spectrum. Neurosci Biobehav Rev. 2019;97:138-151. https://doi.org/10.1016/j.neubiorev.2018.11.013
  25. Shahar E, Zlotnik S, Ravid S, Engel-Yeger B. Sensory processing disabilities in childhood-onset generalized epilepsy. J Pediatr Neurol. 2013;11(2):83-88. https://doi.org/10.3233/JPN-130569
  26. Parham LD, Ecker C, Kuhaneck H, Henry D, Glennon T. Sensory Processing Measure (SPM) Manual. Los Angeles: Western Psychological Services; 2007.
  27. Brown T, Almiento L, Yu ML, Bhopti A. The Sensory Processing Measure-Second Edition: a critical review and appraisal. Occup Ther Health Care. 2024;38(3):842-875. https://doi.org/10.1080/07380577.2023.2294174
  28. Ozbakir M. Duyusal İşleme Ölçeği – Ev Formu’nun Türkiye koşullarına uyarlanması [master’s thesis]. İstanbul: Marmara Üniversitesi; 2010.
  29. Zeileis A, Hothorn T. Diagnostic checking in regression relationships. R News. 2002;2(3):7-10.
  30. Lenth R. emmeans: Estimated marginal means, aka least-squares means [Internet]. 2025. Available from: https://rvlenth.github.io/emmeans/
  31. Zeileis A, Köll S, Graham N. Various versatile variances: an object-oriented implementation of clustered covariances in R. J Stat Softw. 2020;95:1-36. https://doi.org/10.18637/jss.v095.i01
  32. Velluzzi F, Deledda A, Onida M, Loviselli A, Crnjar R, Sollai G. Relationship between olfactory function and body mass index in normal weight healthy subjects and patients with overweight or obesity. Nutrients. 2022;14(6):1262. https://doi.org/10.3390/nu14061262
  33. Melis M, Tomassini Barbarossa I, Crnjar R, Sollai G. Olfactory sensitivity is associated with body mass index and polymorphism in the voltage-gated potassium channel Kv1.3. Nutrients. 2022;14(23):4986. https://doi.org/10.3390/nu14234986
  34. Fernandez-Garcia JC, Alcaide J, Santiago-Fernandez C, Roca-Rodriguez MM, Aguera Z, Baños R, et al. An increase in visceral fat is associated with a decrease in the taste and olfactory capacity. PLoS One. 2017;12(2):e0171204. https://doi.org/10.1371/journal.pone.0171204
  35. Rohde K, Schamarek I, Blüher M. Consequences of obesity on the sense of taste: taste buds as treatment targets? Diabetes Metab J. 2020;44(4):509-528. https://doi.org/10.4093/dmj.2019.0254
  36. Mameli C, Cattaneo C, Panelli S, Comandatore F, Sangiorgio A, Bedogni G, et al. Taste perception and oral microbiota are associated with obesity in children and adolescents. PLoS One. 2019;14(9):e0221656. https://doi.org/10.1371/journal.pone.0221656
  37. Fathi M, Javid AZ, Mansoori A. Effects of weight change on taste function: a systematic review. Nutr J. 2023;22:50. https://doi.org/10.1186/s12937-023-00852-7
  38. Alpcan A, Bayar Muluk N, Inal M, Kömürcü Erkmen SP, Şencan Z. Peripheral and central smell regions in children with epilepsy: an MRI evaluation. J Clin Neurosci. 2022;95:99-105. https://doi.org/10.1016/j.jocn.2021.11.041
  39. Zhang Z, Liao W, Chen H, Mantini D, Ding JR, Xu Q, et al. Altered functional-structural coupling of large-scale brain networks in idiopathic generalized epilepsy. Brain. 2011;134(10):2912-2928. https://doi.org/10.1093/brain/awr223
  40. Nuyts S, D’Souza W, Bowden SC, Vogrin SJ. Structural brain abnormalities in genetic generalized epilepsies: a systematic review and meta-analysis. Epilepsia. 2017;58(12):2025-2037. https://doi.org/10.1111/epi.13928
  41. Mazzola L, Royet JP, Catenoix H, Montavont A, Isnard J, Mauguière F. Gustatory and olfactory responses to stimulation of the human insula. Ann Neurol. 2017;82(3):360-370. https://doi.org/10.1002/ana.25022
  42. Brodie MJ, Besag F, Ettinger AB, Mula M, Gobbi G, Comai S, et al. Epilepsy, antiepileptic drugs, and aggression: an evidence-based review. Pharmacol Rev. 2016;68(3):563-602. https://doi.org/10.1124/pr.115.012021
  43. Sills GJ, Rogawski MA. Mechanisms of action of currently used antiseizure drugs. Neuropharmacology. 2020;168:107966. https://doi.org/10.1016/j.neuropharm.2020.107966
  44. Yuan X, Fu Z, Ji P, Guo L, Al-Ghamdy AO, Alkandiri A, et al. Selenium nanoparticles pre-treatment reverses behavioral, oxidative damage, neuronal loss and neurochemical alterations in pentylenetetrazole-induced epileptic seizures in mice. Int J Nanomedicine. 2020;15:6339-6353. https://doi.org/10.2147/IJN.S259188
  45. Kanemura H. Therapeutic strategies in children with epilepsy: a quality-of-life-related perspective. J Clin Med. 2024;13(2):405. https://doi.org/10.3390/jcm13020405
  46. Carter B, Cook G, Bray L, Collingwood A, Saron H, Rouncefield-Swales A. Parents’ and caregivers’ fears and concerns about their child’s epilepsy: a scoping review. PLoS One. 2022;17(9):e0274001. https://doi.org/10.1371/journal.pone.0274001