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Sistemik lupus eritematozuslu hastalarda serum YKL-40, proteinüri ve inflamasyon düzeyi arasındaki ilişki

The correlation between serum YKL-40, proteinuria and inflammation in patients with systemic lupus erythematosus

İlyas Öztürk(Department of Internal Medicine, Division of Nephrology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Türkiye)0000-0001-9431-8068
Fatma Betül Güzel(Department of Internal Medicine, Division of Nephrology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Türkiye)0000-0003-1569-9654
Serhat Kura(Department of Internal Medicine, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Türkiye)0000-0001-9973-7982
Enes Süleyman Gün(Department of Internal Medicine, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Türkiye)0009-0009-7313-4142
Burak Okyar(Department of Internal Medicine, Division of Rheumatology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Türkiye)0000-0002-9028-9930
Sinan Kazan(Department of Internal Medicine, Division of Nephrology, Afyonkarahisar Health Science University, Faculty of Medicine, Afyonkarahisar, Türkiye)0000-0001-7290-4680
Muhammed Seyithanoğlu(Department of Biochemistry, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaraş, Türkiye)0000-0002-8027-7549
Gözde Yıldırım Çetin(Department of Internal Medicine, Division of Rheumatology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Türkiye)0000-0001-9680-7535
Orçun Altunören(Department of Internal Medicine, Division of Nephrology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Türkiye)0000-0002-8913-4341
Özkan Güngör(Department of Internal Medicine, Division of Nephrology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Türkiye)0000-0003-1861-5452
Sayfa
25–30
Yayın Tarihi
2026-01-11
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bulgular: Hastaların yaş ortalaması 38±14 yıl olup %94’ü kadındı.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amaç: YKL-40; akut ve kronik inflamasyon yanında kanser ile de ilişkili bir proteindir.
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Temel Bulgular & Veri:Diyabetik ve böbrek nakilli hastalarda serum YKL-40 düzeyinin proteinüri ile ilişkili olduğu bildirilmiştir.
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Sonuç & Katkı:Bulgular: Hastaların yaş ortalaması 38±14 yıl olup %94’ü kadındı.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:2022 Verileri
⚙️Değişkenler:Inflamasyon · proteinüri · sistemik lupus eritematozus

Özet

Amaç: YKL-40; akut ve kronik inflamasyon yanında kanser ile de ilişkili bir proteindir. Hücre proliferasyonu, diferansiasyonu, anjiogenez, inflamasyon ve ekstrasellüler matriks remodellinginde görevli bu proteinler normalde nötrofiller, makrofajlar ve kanser hücreleri tarafından üretilir. Ayrıca endotel disfonksiyonunun ve aterosklerozun da bir göstergesidir. Diyabetik ve böbrek nakilli hastalarda serum YKL-40 düzeyinin proteinüri ile ilişkili olduğu bildirilmiştir. Biz de bu çalışmada, literatürde ilk defa, Sistemik Lupus Eritematozus (SLE) hastalarında YKL-40 düzeyi ile proteinüri miktarı ve inflamasyon belirteçleri arasındaki ilişkiyi incelemeyi amaçladık. Gereç ve Yöntemler: Çalışmaya Haziran 2022–Ocak 2023 tarihleri arasında Nefroloji Polikliniğe başvuran 51 SLE hastası dahil edildi. Kan ve idrar tetkik sonuçları hastaların rutin tetkiklerinden elde edildi. YKL- 40 düzeyi ELISA yöntemiyle ölçüldü. Bulgular: Hastaların yaş ortalaması 38±14 yıl olup %94’ü kadındı. Ortanca kreatin 0.72 (0.36-2.62) mg/dl, ortalama tahmini glomerüler filtrasyon hızı 99±31 ml/dk, ortalama C-reaktif protein (CRP) 8±7 mg/L, ortanca eritrosit sedimentasyon hızı (ESH) 14.5 (4-72) mm/sa, ortanca proteinüri miktarı 190 (69-4959) mg/g ve ortalama YKL-40 düzeyi 12.9±9.2 pg/ml’ydi. Korelasyon analizinde, YKL-40; glukoz, CRP, ESH ile pozitif korele [sırasıyla (p=0.01, r=0.26), (p=0.02, r=0.06), (p=0.01, r=0.11)], kalsiyum, albümin, intakt parathormon ve kompleman-3 düzeyi ile negatif korele [sırasıyla (p<0.001, r=-0.41), (p=0.01, r=-0.37), (p=0.01, r=-0.41), (p<0.001, r=-0.52)] bulundu. YKL-40 düzeyi ile proteinüri miktarı arasında ilişki tespit edilmedi (p=0.68, r=0.18). Sonuç: SLE hastalarında YKL-40 düzeyi ile CRP ve ESH gibi inflamasyon markerları arasında ilişki bulunmakla birlikte, proteinüri miktarıyla bir ilişki bulunamamıştır.

Abstract

Aim: YKL-40 is a protein associated with acute and chronic inflammation and cancer. Neutrophils, macrophages, and cancer cells normally produce it. It plays a role in cell proliferation, differentiation, angiogenesis, inflammation, and extracellular matrix remodeling. It is also a marker of endothelial dysfunction and atherosclerosis. Serum YKL-40 has been reported to be associated with proteinuria in diabetic and renal transplant patients. In this study, we aimed to investigate, for the first time in the literature, the relationship between the amount of proteinuria and inflammatory markers and YKL-40 in patients with systemic lupus erythematosus (SLE). Material and Methods: Fifty-one patients with SLE who presented to the adult nephrology outpatient clinic between June 2022 and January 2023 were included in the study. Blood and urine test results were obtained from the patients' routine examinations. ELISA was used to determine YKL-40. Results: The mean age of the patients was 38±14 years and 94% were female. The median creatinine was 0.72 (0.36-2.62) mg/dl, the mean estimated glomerular filtration rate was 99±31 ml/min, the mean C-reactive protein (CRP) was 8±7 mg/L, the median erythrocyte sedimentation rate (ESR) was 14.5 (4-72) mm/hour, the median amount of proteinuria was 190 (69-4959) mg/g and the mean YKL-40 was 12.9±9.2 pg/ ml. In correlation analysis, YKL-40 was positively correlated with glucose, CRP, and ESR [respectively (p=0.01, r=0.26), (p=0.02, r=0.06), (p=0.01, r=0.11)], and negatively correlated with calcium, albumin, intact parathyroid hormone, and complement-3 [respectively (p<0.001, r=-0.41), (p=0.01, r=-0.37), (p=0.01, r=-0.41), (p<0.001, r=-0.52)]. No correlation was found between YKL-40 and the amount of proteinuria (p=0.68, r=0.18). Conclusion: Serum YKL-40 was found to be associated with inflammatory markers such as CRP and ESR in SLE patients, but not with the amount of proteinuria.

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Öztürk, İ., Güzel, F. B., Kura, S., Gün, E. S., Okyar, B., Kazan, S., Seyithanoğlu, M., Çetin, G. Y., Altunören, O., Güngör, Ö. (2026). Sistemik lupus eritematozuslu hastalarda serum YKL-40, proteinüri ve inflamasyon düzeyi arasındaki ilişki. Batı Karadeniz Tıp Dergisi, Cilt: 10 Sayı: 1, 25–30. https://doi.org/10.29058/mjwbs.1793565

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