Köpekte nörosarkomatöz farklılaşma gösteren oral metastatik melanom olgusu

Amaç & Hipotez:Bu çalışmada 16 yaşlı erkek terrier köpekte ön mandibular bölgede sürekli büyüyen, ülserli ve hafif pigmentasyon gösteren tümöral kitle gözlendi.

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Temel Bulgular & Veri:İmmunohistokimyasal incelmelerde, tümör vimentin, Melan-A, NSE ve GFAP pozitif; HMB45, S100, MBP, desmin, SMA ve pansitokeratin negatifti.

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Sonuç & Katkı:Olgu palisad ve yalancı-palisadlarla birlikte nörosarkomatöz farklılaşma gösteren malign oral melanom olarak tanımlandı

🔬Tür:Letter to Editor

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:Dog · neural differentiation · neurosarcomatous differentiation

Özet

Bu çalışmada 16 yaşlı erkek terrier köpekte ön mandibular bölgede sürekli büyüyen, ülserli ve hafif pigmentasyon gösteren tümöral kitle gözlendi. Mikroskobik olarak, tümör iki komponentten oluşmaktaydı. Birincisi epitel benzeri veya iğ şekilli, melanin pigmenti içeren ya da içermeyen hücrelerden oluşan klasik malign melanomdu. İkinci component ise melanin pigmenti içermeyen tipik palisad (Verocay cisimcikleri) ve yalancı-palisadlardan oluşmaktaydı. İmmunohistokimyasal incelmelerde, tümör vimentin, Melan-A, NSE ve GFAP pozitif; HMB45, S100, MBP, desmin, SMA ve pansitokeratin negatifti. Melan-A boyanması klasik melanom alanları ile sınırlıydı. Palisad ve yalancı-palisadlar vimentin, NSE, GFAP için pozitif, diğer antikorlar için negatifti. Lenf yumurusu metastazında doku iğ tarzında hücrelereden oluşmuştu ve vimentin ile Melan-A için pozitifti. Olgu palisad ve yalancı-palisadlarla birlikte nörosarkomatöz farklılaşma gösteren malign oral melanom olarak tanımlandı

Abstract

A 16-year-old male terrier dog was presented with a history of progressively growing ulcerated and slightly pigmented oral masses on the rostral mandible. Microscopically, the tumor composed of two different components. One component was conventional malignant melanoma including epitheloid or spindle-shaped components with/without melanin pigment. The other component was typical palisades (Verocay bodies) and pseudopalisades, with no melanin pigment. Immunohistochemical analysis revealed that the tumor was positive for vimentin, Melan-A, NSE, and GFAP, and negative for HMB45, S100, MBP, desmin, SMA, pan-cytokeratin. Melan-A reactivity was limited to the upper conventional melanoma areas. Nuclear palisading and pseudopalisading structures were positive for vimentin, NSE, GFAP whereas negative for other antibodies. Metastatic lymph node displayed spindle cell melanoma, with immunoreactivity for vimentin and Melan-A. The diagnosis was typical of oral malignant melanoma including nuclear palisading and pseudopalisading components, suggesting neurosarcomatous differentiation in a dog

Anahtar kelimeler

Dog neural differentiation neurosarcomatous differentiation oral malignant melanoma

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Bu Makaleye Atıf Yap

Gülbahar, M. Y., Özak, A., Kabak, Y. B., Karayiğit, M. Ö., Gacar, A. (2016). Köpekte nörosarkomatöz farklılaşma gösteren oral metastatik melanom olgusu. Ankara Üniversitesi Veteriner Fakültesi Dergisi, Volume: 63 Issue: 1. https://doi.org/10.1501/Vetfak_0000002714

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Kaynakça (11)

Brat DJ, Castellano-Sanchez AA, Hunter SB, Pecot M, Cohen C, Hammond EH, Devi SN, Kaur B, Van Meir EG (2004): Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population. Cancer Res, 64, 920- 927.
Brown CC, Baker DC, Barker IK (2007): Alimentary system, 29-30. In: Maxie MG (eds.), Jubb, Kennedy and Palmer’s Pathology of Domestic Animals, 5th Edit., Vol 2, Philadelphia, Saunders Elsevier, USA. 3. Chijiwa K, Uchida K, Immunohistochemical evaluation of canine peripheral nerve sheath tumors and other soft tissue sarcomas. Vet Pathol, 41, 307-318. Tateyama S (2004):
Goldschmidt MH and Hendrick MJ (2002): Tumors of the skin and soft tisuues, 78-84. In: Meuten DJ (ed.), Tumors in Domestic Animals, 4th Edit., Iowa State Press, USA.
Head KW, Else RW, Dubielzig RR (2002): Tumors of the alimentary tract, 401-430. In: Meuten DJ (ed.), Tumors in Domestic Animals, 4th Edit., Iowa State Press, USA.
Katayama KI, Kuroki K, Uchida K, Nakayama H, Sakai M, Mochizuki M, Nishimura R, Sasaki N, Doi K (2001): A case of canine primitive neuroectodermal tumor (PNET). J Vet Med Sci, 63, 103-105.
Maize JC, Foster G (1979): Age-related changes in melanocytic naevi. Clin Exp Dermatol, 4, 49-58.
Patnaik AK, Erlandson RA, Lieberman PH (1984): Canine malignant melanotic schwannomas: a light and electron microscopic study of two cases. Vet Pathol, 21, 483-488.
Ramos-Vara JA, Beissenherz ME, Miller MA, Johnson GC, Pace LW Fard A, Kottler SJ (2000): Retrospective study of 338 canine oral melanomas with clinical, histologic, and immunohistochemical review of 129 cases. Vet Pathol, 37, 597-608.
Smith SH, Goldschmidt MH, McManus PM (2002): A comparative review of melanocytic neoplasms. Vet Pathol, 39, 651-678.
Summers BA (2011): Melanocytic nevi, melanoma and malignant peripheral nerve sheath tumours: not in the textbook. 62nd Annual Meeting of the American College of Veterinary Pathologists and 46th Annual Meeting of the American Society for Veterinary Clinical Pathology, Nashville Tennessee, USA.
Wippold FJ 2nd, Lämmle M, Anatelli F, Lennerz J, Perry A (2006): Neuropathology for the neuroradiologist: palisades and pseudopalisades. Am J Neuroradiol, 27, 2037-2041. Geliş tarihi: 21.10.2014 / Kabul tarihi: 21.01.2015 Address for correspondence: Dr. MustafaYavuz Gülbahar Ondokuz Mayıs University, Faculty of Veterinary Medicine, Department of Pathology, Kurupelit 55139 Samsun-Turkey e-mail: [email protected] and [email protected]