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Dergiler / Ankara Üniversitesi Veteriner Fakültesi Dergisi / 2026 / Volume: 73 Issue: 1

The effects of SNPs between exons 6-9 in the STAT5A gene on milk yield in Anatolian buffalo

Emsal İbiş(KUTAHYA HEALTH SCIENCES UNIVERSITY)0000-0001-8006-2954
Metin Erdoğan(AFYON KOCATEPE UNIVERSITY)0000-0003-0975-1989
Sayfa
—
Yayın Tarihi
2026-01-01
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In conclusion, our findings suggest that SNP 12237 can be used in buffalo breeding programs to improve milk yield.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:The Signal Transducer and Activator of Transcription 5A (STAT5A) gene plays a crucial role in the development of the mammary gland and milk production by mediating prolactin (PRL) signaling.
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Temel Bulgular & Veri:These functions make STAT5A a promising candidate gene for further research, especially in milk-producing animals.
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Sonuç & Katkı:In conclusion, our findings suggest that SNP 12237 can be used in buffalo breeding programs to improve milk yield.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Anatolian Buffalo · Milk Yield · SNP

Abstract

The Signal Transducer and Activator of Transcription 5A (STAT5A) gene plays a crucial role in the development of the mammary gland and milk production by mediating prolactin (PRL) signaling. These functions make STAT5A a promising candidate gene for further research, especially in milk-producing animals. The aim of this study was to determine the relationship between polymorphisms in the 1720 bp segment spanning exons 6-9 of the STAT5A gene and the milk yield of 192 Anatolian buffalo raised in the Afyonkarahisar region. The total of 13 polymorphisms were identified through Sanger sequencing, including five in the 7th intron, seven in the 8th intron, and only one of them in the 8th exon. The relationship between adjusted milk yields and SNPs was analyzed using ANOVA (one-way analysis of variance). The association between milk and SNP 12237 (g+12237 C>T) was located in exon 8 of the STAT5A gene. Therefore, milk yield was found to be significant (P<0.01). Buffaloes with the CC genotype were found to produce less milk than buffaloes with the CT genotype for this SNP. In conclusion, our findings suggest that SNP 12237 can be used in buffalo breeding programs to improve milk yield.

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Bu Makaleye Atıf Yap

İbiş, E., Erdoğan, M. (2026). The effects of SNPs between exons 6-9 in the STAT5A gene on milk yield in Anatolian buffalo. Ankara Üniversitesi Veteriner Fakültesi Dergisi, Volume: 73 Issue: 1. https://doi.org/10.33988/auvfd.1675808

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