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Dergiler / Düzce Tıp Fakültesi Dergisi / 2026 / Volume: 28 Issue: 2

Primary Localized Amyloidosis of the Nasopharynx: A Case Report

Deniz Baklacı(Department of Otorhinolaryngology–Head and Neck Surgery, Zonguldak Bülent Ecevit University Hospital)0000-0001-8449-4965
Oğuz Can Karakaş(Department of Otorhinolaryngology–Head and Neck Surgery, Zonguldak Bülent Ecevit University)0009-0004-5642-5582
Aleyna Şivetoğlu(Department of Otorhinolaryngology–Head and Neck Surgery, Zonguldak Bülent Ecevit University)0009-0006-7262-181X
Filiz Kutlu(Department of Pathology, Zonguldak Bülent Ecevit University)0000-0003-1743-457X
Sayfa
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Yayın Tarihi
2026-08-21
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Histopathological confirmation is essential, and systemic involvement must be meticulously excluded.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amyloidosis is characterized by the extracellular deposition of abnormally folded proteins.
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Temel Bulgular & Veri:A 67-year-old female presented with nasal congestion, throat lump sensation, and left-sided conductive hearing loss.
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Sonuç & Katkı:Histopathological confirmation is essential, and systemic involvement must be meticulously excluded.
🔬Tür:Case Report
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Amyloidosis · localized amyloid · head and neck neoplasms

Abstract

Amyloidosis is characterized by the extracellular deposition of abnormally folded proteins. While localized forms occur in the head and neck, nasopharyngeal involvement is rare and can mimic malignancies. We present a rare case of primary localized nasopharyngeal amyloidosis. A 67-year-old female presented with nasal congestion, throat lump sensation, and left-sided conductive hearing loss. Endoscopy revealed a yellow-colored mass in the left nasopharynx. MRI showed a homogeneously enhancing lesion without destruction. Diagnosis was confirmed by histopathology demonstrating apple-green birefringence with Congo red staining. Systemic amyloidosis was excluded through comprehensive evaluation. The patient was managed with close follow-up, and no progression was observed over five years. Nasopharyngeal amyloidosis should be considered in the differential diagnosis of nasopharyngeal masses. Histopathological confirmation is essential, and systemic involvement must be meticulously excluded.

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Bu Makaleye Atıf Yap

Baklacı, D., Karakaş, O. C., Şivetoğlu, A., Kutlu, F. (2026). Primary Localized Amyloidosis of the Nasopharynx: A Case Report. Düzce Tıp Fakültesi Dergisi, Volume: 28 Issue: 2. https://doi.org/10.18678/dtfd.1865876

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