Dergiler / Sigma Mühendislik ve Fen Bilimleri Dergisi / 2026 / Volume: 34 Issue: 1

PRODUCTION AND OPTIMIZATION METHOD OF SMART HYDROGELS BASED ON BIOCOMPATIBLE POLYMER FOR CONTROLLED INSULIN RELEASE

Hediye Irem Ozgunduz(YILDIZ TECHNICAL UNIVERSITY)
Hava Gizem Kandılcı(YILDIZ TECHNICAL UNIVERSITY)
Nil Acaralı(YILDIZ TECHNICAL UNIVERSITY)
Hanifi Sarac(YILDIZ TECHNICAL UNIVERSITY)
Sayfa
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Yayın Tarihi
2016-03-01
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

After entrapped method, loading efficiency values were calculated. and the hydrogels produced were characterized by using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning electron microscope (SEM) analysis.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:The aim of controlled insulin delivery study experiments is to produce the smart hydrogel to use insulin release for human body.
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Temel Bulgular & Veri:Insulin entrapped p(HEMA-co-Eudragit L-100) hydrogels containing different ratios of 2-Hydroxyethyl methacrylate (HEMA) and Eudragit L-100 were synthesized by using ammonium persulfate (APS) as an initiator and ethylene glycol dimethacrylate (EGDMA) as a cross linker and new alternative ways were worked on to find and develop.
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Sonuç & Katkı:After entrapped method, loading efficiency values were calculated. and the hydrogels produced were characterized by using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning electron microscope (SEM) analysis.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Hydrogel · insulin · Taguchi

Abstract

The aim of controlled insulin delivery study experiments is to produce the smart hydrogel to use insulin release for human body. Insulin entrapped p(HEMA-co-Eudragit L-100) hydrogels containing different ratios of 2-Hydroxyethyl methacrylate (HEMA) and Eudragit L-100 were synthesized by using ammonium persulfate (APS) as an initiator and ethylene glycol dimethacrylate (EGDMA) as a cross linker and new alternative ways were worked on to find and develop. Taguchi method was used and optimum synthesis conditions were determined. Insulin was entrapped into hydrogels as synthesis. After entrapped method, loading efficiency values were calculated. and the hydrogels produced were characterized by using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning electron microscope (SEM) analysis.

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Bu Makaleye Atıf Yap

Ozgunduz, H. I., Kandılcı, H. G., Acaralı, N., Sarac, H. (2016). PRODUCTION AND OPTIMIZATION METHOD OF SMART HYDROGELS BASED ON BIOCOMPATIBLE POLYMER FOR CONTROLLED INSULIN RELEASE. Sigma Mühendislik ve Fen Bilimleri Dergisi, Volume: 34 Issue: 1. https://ajindex.com/articles/1345231

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Kaynakça (13)

  1. Byrne M.E., Park K., Peppas N.A., “Synthesis, Swelling and Drug Release Behavior of Poly(N,N-diethylacrylamide-co-N-hydroxymethyl acrylamide) Hydrogel”, Adv. Drug Deliver. Rev., 54(1), 149, 2002.
  2. Zou X., Zhao X., Ye L., et al., “Preparation and Drug Release Behavior of pH-Responsive Bovine Serum Albumin-Loaded Chitosan Microspheres”, J. Ind. Eng. Chem., article in press, DOI: 10.1016/j.jiec.2014.06.012, 2014.
  3. de Leede L.G.J., de Boer A.G., Ptirtzgen E., et al., “Rate-Controlled Rectal Drug Delivery in Man with a Hydrogel Preparation”, J. Control. Release, 4, 17, 1986.
  4. Zhang Y., Wu X., Meng L., et al., “Thiolated Eudragit Nanoparticles for Oral Insulin Delivery: Preparation, Characterization and in Vivo Evaluation”, Int. J. Pharm., 436, 341, 2012.
  5. Huynh D.P., Im G.J., Chae S.Y., et al., “Controlled Release of Insulin from pH/Temperature-Sensitive Injectable Pentablock Copolymer Hydrogel”, J. Control. Release, 137, 20 2009.
  6. Chaturvedi K., Ganguly K., Nadagouda M.N., et al., “Polymeric Hydrogels for Oral Insulin Delivery”, J. Control. Release, 165, 129, 2013.
  7. Hao S., Wang B., Wang Y., et al., “Preparation of Eudragit L 100-55 Enteric Nanoparticles by a Novel Emulsion Diffusion Method”, Colloid. Surface B, 108, 127, 2013.
  8. Gandhi A., Jana S., Sen K.K., “In-vitro Release of Acyclovir Loaded Eudragit RLPO®Nanoparticles for Sustained Drug Delivery”, Int. J. Biol. Macromol., 67, 478, 2014.
  9. Sadeghi M., “Synthesis and Swelling Behaviors of Graft Copolymer Based on Chitosan-g-Poly(AA-co-HEMA)”, Int. J. Chem. Eng. App., 1(4), 354, 2010.
  10. Emileh A., Vasheghani-Farahani E., Imani M., “Swelling Behavior, Mechanical Properties and Network Parameters of pH- and Temperature Sensitive Hydrogels of Poly((2-dimethyl amino) ethyl methacrylate-co-butyl methacrylate)”, Eur. Polym. J., 43, 1986, 2007.
  11. Raghavendra C.M., Vidhya R., Tejraj M.A., “pH-Sensitive Oral Insulin Delivery Systems Using Eudragit Microspheres”, Drug Dev. Ind. Pharm., 37(8), 977–985, 2011.
  12. Lowman A.M., Morishita M., Kajita M., et al., “Oral Delivery of Insulin Using pH-Responsive Complexation Gels”, Journal of Pharmaceutical Sciences, 88(9), 933-937, 2000.
  13. Kaushik G., Thakur I.S., “Isolation and Characterization of Distillery Spent Wash Color Reducing Bacteria and Process Optimization by Taguchi Approach”, Int. Biodeter. Biodegr., 63, 420, 2009.