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Dergiler / Türk Tarım ve Doğa Bilimleri Dergisi / 2026 / Volume: 13 Issue: 2

Bioactive Potential of The Endemic Verbascum bellum: Cytotoxicity Against Cancer Cells and Antimicrobial Effects

Anara Babayeva(MUGLA UNIVERSITY)0000-0001-6797-3366
Bekir Çöl(Muğla Sıtkı Koçman University)0000-0001-8997-4116
Ramazan Mammadov(ODLAR YURDU UNIVERSITY)0000-0003-2218-5336
Sayfa
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Yayın Tarihi
2026-04-27
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

These findings highlight the potential of this endemic species as a promising source of bioactive compounds for further pharmacological investigation.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Natural products remain a major source for the discovery of novel therapeutic agents, particularly in cancer treatment and the fight against antimicrobial resistance.
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Temel Bulgular & Veri:Cytotoxic activity was assessed in three human cancer cell lines (Huh-7, Caco-2, and PC-3) using the MTT assay, while antibacterial activity was determined against two Gram-positive ( Staphylococcus aureus and Bacillus subtilis ) and two Gram-negative ( Escherichia coli and Pseudomonas aeruginosa ) bacterial strains using the agar well diffusion method.
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Sonuç & Katkı:These findings highlight the potential of this endemic species as a promising source of bioactive compounds for further pharmacological investigation.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Endemic plant · cancer cell line · anticancer

Abstract

Natural products remain a major source for the discovery of novel therapeutic agents, particularly in cancer treatment and the fight against antimicrobial resistance. Verbascum bellum , an endemic Turkish species, was evaluated for its cytotoxic and antimicrobial potential using methanolic extracts prepared from its leaves and flowers. Cytotoxic activity was assessed in three human cancer cell lines (Huh-7, Caco-2, and PC-3) using the MTT assay, while antibacterial activity was determined against two Gram-positive ( Staphylococcus aureus and Bacillus subtilis ) and two Gram-negative ( Escherichia coli and Pseudomonas aeruginosa ) bacterial strains using the agar well diffusion method. Among the tested extracts, the leaf extract demonstrated significant and selective cytotoxicity, particularly against Huh-7 hepatocellular carcinoma cells after 72 hours of exposure (IC₅₀ = 24.6 ± 5.1 µg/mL). Both extracts also exhibited notable antimicrobial activity, with strong inhibition observed against B. subtilis (up to 19 mm) and E. coli (up to 23 mm). To our knowledge, this is the first report describing the cytotoxic activity of V. bellum . These findings highlight the potential of this endemic species as a promising source of bioactive compounds for further pharmacological investigation.

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Bu Makaleye Atıf Yap

Babayeva, A., Çöl, B., Mammadov, R. (2026). Bioactive Potential of The Endemic Verbascum bellum: Cytotoxicity Against Cancer Cells and Antimicrobial Effects. Türk Tarım ve Doğa Bilimleri Dergisi, Volume: 13 Issue: 2. https://doi.org/10.30910/turkjans.1839745

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