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Dergiler / Zeynep Kamil Tıp Bülteni / 2026 / Cilt: 49 Sayı: 1

Ailevi Akdeniz Ateşi Olan 40 Gebenin Perinatal Sonuçları

Perinatal Outcomes of 40 Pregnancies with Familial Mediterranean Fever

Ebru Alıcı Davutoğlu(İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi ,Kadın Hastalıkları ve Doğum ABD, Perinatoloji Bilim Dalı)
Ayşegül Özel(İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi ,Kadın Hastalıkları ve Doğum ABD, Perinatoloji Bilim Dalı)0000-0002-0283-1049
Hakan Erenel(İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi ,Kadın Hastalıkları ve Doğum ABD, Perinatoloji Bilim Dalı)
Rıza Madazlı(İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi ,Kadın Hastalıkları ve Doğum ABD, Perinatoloji Bilim Dalı)
Sayfa
77–79
Yayın Tarihi
2018-03-05
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bulgular: Ortalama hasta yaşı 30.75 ±6.15, nulliparite oranı %42,5 bulundu.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amaç : Ailevi Akdeniz Ateşi (AAA) tanısı olan, gebe olguların maternal ve fetal sonuçlarının değerlendirilmesi amaçlanmıştır.
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Temel Bulgular & Veri:Gereç ve Yöntem : Çalışmamız 2013-2017 yılları arasında üniversitemizin perinataloji kliniğinde gebelikleri takip edilmiş 40 AAA olgusunun dosya verilerinin retrospektif olarak incelenmesiyle yapıldı.
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Sonuç & Katkı:Bulgular: Ortalama hasta yaşı 30.75 ±6.15, nulliparite oranı %42,5 bulundu.
🔬Tür:Araştırma Makalesi
📍Kapsam:2013-2017 · 7 hasta
⚙️Değişkenler:Ailevi Akdeniz Ateşi · perinatal sonuçlar · : Familial Mediterranean Fever

Özet

Amaç : Ailevi Akdeniz Ateşi (AAA) tanısı olan, gebe olguların maternal ve fetal sonuçlarının değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem : Çalışmamız 2013-2017 yılları arasında üniversitemizin perinataloji kliniğinde gebelikleri takip edilmiş 40 AAA olgusunun dosya verilerinin retrospektif olarak incelenmesiyle yapıldı. Hastaların klinik özellikleri , obstetrik ve perinatal sonuçları değerlendirildi. Bulgular: Ortalama hasta yaşı 30.75 ±6.15, nulliparite oranı %42,5 bulundu. Ortalama hastalık süresi 8,36 ± 5.44 yıl olarak bulundu. Gebelik sırasında 7 hasta atak geçirdi. Hastaların % 90 ’ ı medikal tedavi almaktaydı. Ortalama doğum haftası 37,3±4.5, ortalama doğum kilosu 3115±547 gr bulundu. Preterm doğum, fetal büyüme kısıtlılığı ,preeklampsi görülme oranları sırasıyla; %10 , %5 , %10, olarak bulundu. Fetal ve neonatal kayıp, ile konjenital anomalili doğum gözlenmedi. Sonuç : AAA tanılı gebelik olgularının yönetiminde multidisipliner yaklaşım ile takip ve tedavinin sağlanması olumlu maternal ve fetal sonuçlar ile ilişkilidir.

Abstract

Objective : To evaluate maternal and fetal outcomes of pregnancies diagnosed with Familial Mediterranean Fever (FMF) Methods : Retrospective analysis of 40 pregnancies diagnosed with FMF who received antenatal care at our perinatology unit between 2012 -2017 included in this clinical study. Clinical characteristics of patients, perinatal and maternal outcomes were evaluated. Results : The mean patient age was 30.75 ±6.15 and the nulliparity rate was 42,5 %. The mean duration of illness was found to be 8,36 ± 5.44 years. 7 patients had an attack during pregnancy. 90 % of the patients received medical treatment. Mean gestational age at delivery was 37,3±4.5 , mean birth weight was 3115±547 g. Preterm delivery, f etal growth restriction and preeclampsia rates were 10, 5, 10 % respectively. Fetal and neonatal loss, congenital anomalous birth was not observed. Conclusion : Multidisciplinary approach to the care of pregnancy diagnosed with FMF is associated with good maternal and fetal outcomes.

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Bu Makaleye Atıf Yap

Davutoğlu, E. A., Özel, A., Erenel, H., Madazlı, R. (2018). Ailevi Akdeniz Ateşi Olan 40 Gebenin Perinatal Sonuçları. Zeynep Kamil Tıp Bülteni, Cilt: 49 Sayı: 1, 77–79. https://doi.org/10.16948/zktipb.333212

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Kaynakça (31)

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  27. 12 Zemer D, Pras M, Sohar E, Modan M,Cabili S, Gafni J. Colchicine in the prevention and treatment of the amyloidosis of familial Mediterranean fever. N Engl J Med 1986 Apr;314 (16):1001–3.
  28. 13 Ofir D, Levy A, Wiznitzer A, Mazor M, Sheiner E Familial Mediterranean fever: An independent risk factor for preterm delivery European Journal of Obstetrics & Gynecology and Reproductive Biology 2008 Dec;141 (2):115–118 14 Yasar 0, Iskender C, Kaymak O, Yaman TS, Uygur D, Danısman N Retrospective evaluation of pregnancy outcomes in women with familial Mediterranean fever J Matern Fetal Neonatal Med 2014 May; 27(7): 733–736 15 Ben-Cherit E, Ben-Cherit A, Berkun Y, Ben-Cherit E Pregnancy outcomes in women with familial Mediterranean fever receiving colchicine: is amniocentesis justified? Arthritis Care Res 2010 Feb; 62(2):143–148
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  30. 19 Venhoff N,Voll RE, Glaser C, Thiel J IL-1-blockade with Anakinra during pregnancy: Retrospective analysis of efficacy and safety in female patients with familial Mediterranean fever Z Rheumatol 2017 Jul; Epub ahead of print
  31. 20 Ilgen U, Küçükşahin O Anakinra use during pregnancy: Report of a case with Familial Mediterranean Fever and infertility. Eur J Rheumatol 2017 Mar; Epub ahead of print