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Dergiler / Online Türk Sağlık Bilimleri Dergisi / 2021 / Cilt: 6 Sayı: 4

Ziprasidon, Aripiprazol, Blonanserin, Siyamemazin ve Nemonaprid'in Farelerde İzole Detrusor Düz Kasına Kronik Etkileri

Chronic Effects of Ziprasidone, Aripiprazole, Blonanserin, Cyamemazine, and Nemonapride on Mice Isolated Detrusor Smooth Muscle

Mehmet Hanifi Tanyeri(YENIKENT GOVERNMENT HOSPITAL, DEPARTMENT OF UROLOGY)0000-0003-2654-2724
Mehmet Emin Büyükokuroğlu(SAKARYA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF MEDICAL PHARMACOLOGY)0000-0002-1452-3879
Pelin Tanyeri(SAKARYA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF MEDICAL PHARMACOLOGY)0000-0002-2987-5834
Rümeysa Keleş(SAKARYA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF MEDICAL PHARMACOLOGY)0000-0002-5554-1918
Şeyma Nur Başarır(SAKARYA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF MEDICAL PHARMACOLOGY)0000-0002-2986-5089
Oguz Mutlu(Kocaeli University, Faculty of Medicine. Department of Pharmacology)0000-0003-0952-0742
Firuzan Akar(Kocaeli University, Faculty of Medicine. Department of Pharmacology)0000-0003-0948-3857
Bekir Faruk Erden(Kocaeli University, Faculty of Medicine. Department of Pharmacology)0000-0002-2542-5158
Güner Ulak(ÜSKÜDAR ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, TIBBİ FARMAKOLOJİ ANABİLİM DALI)0000-0002-6132-6712
Sayfa
500–507
Yayın Tarihi
2021-12-01
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bu çalışmada bu atipik antipsikotik ilaçların organ banyosu kullanılarak farelerde izole edilmiş mesane üzerine etkilerinin belirlenmesi amaçlanmıştır.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amaç: Ziprasidon, aripiprazol, blonanserin, siyamemazin ve nemonaprid şizofreni tedavisinde kullanılan atipik antipsikotik ilaçlardır.
📊
Temel Bulgular & Veri:Amaç: Ziprasidon, aripiprazol, blonanserin, siyamemazin ve nemonaprid şizofreni tedavisinde kullanılan atipik antipsikotik ilaçlardır.
💡
Sonuç & Katkı:Bu çalışmada bu atipik antipsikotik ilaçların organ banyosu kullanılarak farelerde izole edilmiş mesane üzerine etkilerinin belirlenmesi amaçlanmıştır.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Aripiprazol · blonanserin · nemonaprid

Özet

Amaç: Ziprasidon, aripiprazol, blonanserin, siyamemazin ve nemonaprid şizofreni tedavisinde kullanılan atipik antipsikotik ilaçlardır. Bu çalışmada bu atipik antipsikotik ilaçların organ banyosu kullanılarak farelerde izole edilmiş mesane üzerine etkilerinin belirlenmesi amaçlanmıştır.

Abstract

Objective: Ziprasidone, aripiprazole, blonanserin, cyamemazine, and nemonapride are atypical antipsychotic drugs used for the treatment of schizophrenia. This study aimed to identify the effects of these atypical antipsychotic drugs in mice isolated bladder using the organ bath system

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Bu Makaleye Atıf Yap

Tanyeri, M. H., Büyükokuroğlu, M. E., Tanyeri, P., Keleş, R., Başarır, Ş. N., Mutlu, O., Akar, F., Erden, B. F., Ulak, G. (2021). Ziprasidon, Aripiprazol, Blonanserin, Siyamemazin ve Nemonaprid'in Farelerde İzole Detrusor Düz Kasına Kronik Etkileri. Online Türk Sağlık Bilimleri Dergisi, Cilt: 6 Sayı: 4, 500–507. https://doi.org/10.26453/otjhs.974323

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Kaynakça (28)

  1. Abrams P, Cardozo L, Fall M, et al. The standardisation of terminology of lower urinary tract function: Report from the standardisation sub-committee of the International Continence Society. Neurourol Urodyn. 2003;61(1):37-49. doi:10.1016/s0090-4295(02)02243-4
  2. Drake MJ. Do we need a new definition of the overactive bladder syndrome? ICI-RS 2013. Neurourol Urodyn. 2014;33(5):622-624. doi:10.1002/nau.22609
  3. Chuang YC, Liu SP, Lee KS, et al. Prevalence of overactive bladder in China, Taiwanand South Korea: Results from a cross-sectional, population-based study. Low Urin Tract Symptoms. 2019;11(1): 48-55.
  4. Sadananda P, Drake MJ, Paton JF, Pickering AE. A functional analysis of the influence of β 3-adrenoceptors on the rat micturition cycle. J Pharmacol Exp Ther. 2013;347(2):506-515. doi:10.1124/jpet.113.207340
  5. Daly D, Chapple C. Relationship between overactive bladder (OAB) and irritable bowel syndrome (IBS): concurrent disorders with a common pathophysiology? BJU Int. 2013;111(4):530-531. doi:10.1111/j.1464-410X.2013.11019.x
  6. Groat WC, Griffiths D, Yoshimura N. Neural control of the lower urinary tract. Compr Physiol. 2015;5(1): 327-396. doi:10.1002/cphy.c130056
  7. Schmidt AW, Lebel LA, Howard HR Jr, Zorn SH. Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile. Eur J Pharmacol. 2001;425:197-201. doi:10.1016/s0014-2999(01)01188-8
  8. Shapiro DA, Renock S, Arrington E, et al. Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology. Neuropsychopharmacology. 2003;28(8):1400-1411.
  9. Bayazıt H, Kiliçaslan F. Diuarnal Enurisis Secondary to Aripiprazol. Mustafa Kemal Üniv Tıp Derg. 2017;8(31):36-38. doi:10.17944/mkutfd.376533
  10. Kato K, Yamada K, Maehara M, et al. Blonanserin in the treatment of delirium. Psychiatry Clin. Neurosci. 2011;65:389-391. doi:10.1038/sj.npp.1300203
  11. Min A, Kim D. Blonanserin-induced mood alteration in schizophrenia and schizoaffective disorder: two cases. Clin Psychopharmacol Neurosci. 2013;11(3):165-167. doi:10.9758/cpn.2013.11.3.165
  12. Tata 1mg. https://www.1mg.com/generics/blonanserin-212560. Accessed March 3, 2003.
  13. Arnt J, Skarsfeldt T. Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence. Neuropsychopharmacology. 1998;18:63-101. doi:10.1016/S0893-133X(97)00112-7
  14. UK Gabapentin Study Group. Gabapentin in partial epilepsy. Lancet. 1990;335(8698):1114-1117.
  15. Tanyeri MH, Buyukokuroglu ME, Tanyeri P, et al. Effects of long-term treatment with haloperidol, clozapine and aripiprazole on mice isolated vas deferens. Int Urol Nephrol. 2017;49(9):1561-1567.
  16. Bourin M, Nic Dhonnchadha BA, Claude Colombel M, Dib M, Hascoët M. Cyamemazine as an anxiolytic drug on the elevated plus maze and light/dark paradigm in mice. Behav Brain Res. 2001;124(1):87-95.
  17. Horiguchi M, Meltzer HY. Blonanserin reverses the phencyclidine (PCP)-induced impairment in novel object recognition (NOR) in rats: role of indirect 5-HT(1A) partial agonism. Behav Brain Res. 2013;247:158-164. doi: 10.1016/j.bbr.2013.03.027
  18. Auclair AL, Kleven MS, Besnard J, Depoortère R, Newman-Tancredi A. Actions of novel antipsychotic agents on apomorphine-induced PPI disruption: influence of combined serotonin 5-HT1A receptor activation and dopamine D2 receptor blockade. Neuropsychopharmacology. 2006;31(9):1900-1909.
  19. Patra P, Patra S. Research findings on overactive bladder. Curr Urol. 2015;8(1):1-21. doi:10.1159/000365682
  20. Yoshimura N, Chancellor MB. Neurophysiology of lower urinary tract function and dysfunction. Rev Urol. 2003;(5):3-10.
  21. Fowler CJ, Griffiths D, Groat WC. The neural control of micturition. Nature Reviews Neuroscience. 2008;9(6):453-466. doi:10.1038/nrn2401
  22. Pineda RH, Nedumaran B, Hypolite J, et al. Altered expression and modulation of the two-pore-domain (K2P) mechanogated potassium channel TREK-1 in overactive human detrusor. Am J Physiol Renal Physiol. 2017;313:535–546. doi:10.1152/ajprenal.00638.2016
  23. Groat WC, Wickens C. Organization of the neural switching circuitry underlying reflex micturition. Acta Physiologica. 2013;207(1):66-84. doi:10.1111/apha.12014
  24. Zhang J, Cao M, Chen Y, et al. Increased expression of TREK-1 K+ channel in the dorsal root ganglion of rats with detrusor overactivity after partial bladder outlet obstruction. Med Sci Monit. 2018;24:1064-1071. doi:10.12659/MSM.908792
  25. Lei Q, Pan XQ, Chang S, Malkowicz SB, Guzzo TJ, Malykhina AP. Response of the human detrusor to stretch is regulated by TREK-1, a two-pore-domain (K2P) mechano-gated potassium channel. J Physiol. 2014;592(14):3013-3030. doi:10.1113/jphysiol.2014.271718
  26. Cadaveira-Mosquera A, Ribeiro SJ, Reboreda A, Lamas JA. Activation of TREK currents by the neuroprotective agent riluzole in mouse sympathetic neurons. J Neurosci.2011;31(4):1375-1385. doi:10.1523/JNEUROSCI.2791-10.2011
  27. Picardo HP, Joseph H, Sanghee L, et al. Altered detrusor contractility and voiding patterns in mice lacking the mechanosensitive TREK-1 channel. BMC Urol. 2019;19:40. doi:10.1186/s12894-019-0475-3
  28. Yoshimura N, Kuno S, Chancellor MB, De Groat WC, Seki S. Dopaminergic mechanisms underlying bladder hyperactivity in rats with a unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal pathway. Br J Pharmacol. 2003;139(8):1425-1432. doi:10.1038/sj.bjp.0705388