Dergiler / Online Türk Sağlık Bilimleri Dergisi / 2026 / Cilt: 10 Sayı: 1

Hipertansiyonu Olan Geriatrik Hastalarda Dipper/Non-Dipper Paterni ile Nötrofil-Lenfosit Oranı ve Trombosit-Lenfosit Oranı arasındaki İlişki

Relationship Between Dipper/Non-Dipper Pattern and Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Geriatric Patients with Hypertension

Perihan Varım(Özel Focus Kalp Aritmi Merkezi)0000-0002-8827-1280
Ahmet Can Çakmak(SAKARYA ÜNİVERSİTESİ)0000-0001-5168-8907
Sayfa
76–81
Yayın Tarihi
2025-03-17
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bulgular: İki grup arasında cinsiyet, yaş, kronik hastalıklar e sigara içiciliği açısından anlamlı fark yoktu (p>0,005).

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amaç: Nötrofil lenfosit (NLR) ve trombosit lenfosit oranı (PLR), kötü prognozu gösteren bir inflamatuar belirteçtir.
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Temel Bulgular & Veri:Materyal ve Metot: Çalışmaya hipertansiyonu olan 124 geriatrik hasta dahil edildi.
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Sonuç & Katkı:Bulgular: İki grup arasında cinsiyet, yaş, kronik hastalıklar e sigara içiciliği açısından anlamlı fark yoktu (p>0,005).
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Dipper · geriatrik hastalar · NLR

Özet

Amaç: Nötrofil lenfosit (NLR) ve trombosit lenfosit oranı (PLR), kötü prognozu gösteren bir inflamatuar belirteçtir. Non-dipper hipertansiyon, kardiyovasküler olaylar için daha yüksek risk ile ilişkilidir. Bu çalışmanın amacı, dipper ve non-dipper hipertansiyonu olan hastalarda NLR ve PLR arasındaki ilişkiyi araştırmaktır. Materyal ve Metot: Çalışmaya hipertansiyonu olan 124 geriatrik hasta dahil edildi. Hastalar ambulatuvar kan basıncı ölçümüne göre non-dipper (n:62, grup 1) ve dipper (n:62, grup 2) olmak üzere iki gruba ayrıldı. Nötrofil lenfosit (NLR) ve trombosit lenfosit oranı (PLR), mutlak nötrofil sayısı ve trombosit sayısının mutlak lenfosit sayısına bölünmesiyle hesaplandı. Bulgular: İki grup arasında cinsiyet, yaş, kronik hastalıklar e sigara içiciliği açısından anlamlı fark yoktu (p>0,005). Kronik hastalıklar ve sigara kullanımı açısından da anlamlı fark yoktu. NLR grup 1'de 1,96±0,66 iken grup 2'de 1,67±0,68 idi (p:0,005). PLR grup 1'de 146±42,2 iken grup 2'de 115±34,2 idi (p:0,001). Sonuç: Bulgularımız non-dipper HT'li geriatrik hastaların, dipper HT'li hastalara göre anlamlı derecede daha yüksek NLR ve PLR'ye sahip olduğunu göstermektedir. Bu, non-dipper HT'nin daha yüksek inflamasyonla ilişkili olduğunu ve bunun da daha yüksek kardiyovasküler riske katkıda bulunabileceğini göstermektedir.

Abstract

Objective: Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) are inflammatory markers associated with poor prognoses. Non-dipper hypertension (HT) is linked to a higher risk for cardiovascular events. This study aims to investigate the association between NLR and PLR in geriatric patients with dipper and non-dipper HT. Materials and Methods: A total of 124 geriatric patients with HT were included in the study. Based on ambulatory blood pressure monitoring, patients were categorized into two groups: non-dippers (n=62, Group 1) and dippers (n=62, Group 2). NLR and PLR were calculated by dividing the absolute neutrophil and platelet counts, respectively, by the absolute lymphocyte count. Results: There were no significant differences in sex, age, chronic conditions and smoking between the two groups (p>0.005). The NLR was 1.96±0.66 in group 1 and 1.67±0.68 in group 2 (p:0.005). The PLR was 146±42.2 in group 1 and 115±34.2 in group 2 (p:0.001). The NLR and PLR were significantly higher in non-dippers compared to dippers (p<0.005). Conclusion: Our findings demonstrate that geriatric patients with non-dipper HT have significantly higher NLR and PLR compared to those with dipper HT. This suggests that non-dipper HT is associated with greater inflammation, which may contribute to its higher cardiovascular risk.

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Bu Makaleye Atıf Yap

Varım, P., Çakmak, A. C. (2025). Hipertansiyonu Olan Geriatrik Hastalarda Dipper/Non-Dipper Paterni ile Nötrofil-Lenfosit Oranı ve Trombosit-Lenfosit Oranı arasındaki İlişki. Online Türk Sağlık Bilimleri Dergisi, Cilt: 10 Sayı: 1, 76–81. https://doi.org/10.26453/otjhs.1619335

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