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Dergiler / Marmara Medical Journal / 2026 / Volume: 32 Issue: 1

İnsan kronik miyeloid lösemi K562 hücrelerinde karbakolün apoptoza etkisi

Effects of carbachol on apoptosis in human chronic myelogenous leukemic K562 cell line

Banu Aydın
Aysın Tulunay
Emel Ekşioğlu-demiralp
Beki Kan
Hulya Cabadak
Sayfa
—
Yayın Tarihi
2019-01-29
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Amaç: Muskarinik reseptörler merkezi sinir sisteminde

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amaç: Muskarinik reseptörler merkezi sinir sisteminde
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Temel Bulgular & Veri:Amaç: Muskarinik reseptörler merkezi sinir sisteminde
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Sonuç & Katkı:Amaç: Muskarinik reseptörler merkezi sinir sisteminde
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Muscarinic receptors · K562 cells · Carbachol

Özet

Amaç: Muskarinik reseptörler merkezi sinir sisteminde

Abstract

Objectives: Muscarinic receptors mediate diverse actions of

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Bu Makaleye Atıf Yap

Aydın, B., Tulunay, A., Ekşioğlu-demiralp, E., Kan, B., Cabadak, H. (2019). İnsan kronik miyeloid lösemi K562 hücrelerinde karbakolün apoptoza etkisi. Marmara Medical Journal, Volume: 32 Issue: 1. https://doi.org/10.5472/marumj.518983

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Kaynakça (34)

  1. Pierce KL, Premont RT, Lefkowitz RJ. Seven transmembrane receptors. Nat Rev Mol Cell Biol 2002;3:639-50. doi: 10.1038/nrm908
  2. Haga T. Molecular properties of muscarinic acetylcholine receptors. Proc Jpn Acad Ser B Phys Biol Sci 2013;89:226- 56. doi: 10.2183/pjab.89.226
  3. Gutkind JS, Novotny EA, Brann MR, Robbins KC. Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes. Proc Natl Acad Sci USA 1991;88:4703– 07.
  4. Rayford W, Noble MJ, Austenfeld MA, Weigel J, Mebust WK, Shah GV. Muscarinic cholinergic receptors promote growth of human prostate cancer cells. Prostate 1997; 30:160-6. doi: 10.1002/(SICI)1097-0045(19970215)30:3 3.0.CO;2-Q
  5. Luthin GR, Wang P, Zhou H, Dhanasekaran D, Ruggieri MR. Role of m1 receptor-G protein coupling in cell proliferation in the prostate. Life Sci 1997;60:963-8. doi: 10.1016/S0024- 3205(97)00035-0
  6. Wang L, Jiang R, Song SD, Hua ZS, Wang JW, Wang YP. Angelica sinensis polysaccharide induces erythroid differentiation of human chronic myelogenous leukemia k562 cells. Asian Pac J Cancer Prev 2015;16:3715-21.
  7. Taverna S, Giallombardo M, Pucci M, et al. Curcumin inhibits in vitro and in vivo chronic myelogenous leukemia cells growth: a possible role for exosomal disposal of miR-21. Oncotarget 2015;6:21918-33. doi: 10.18632/ oncotarget.4204
  8. Klein E, Ben-Bassat H, Neumann H, et al. Properties of the K562 cell line, derived from a patient with chronic myeloid leukemia. Int J Can 1976;18:421-31. doi: 10.1002/ ijc.291.018.0405
  9. Cabadak H, Aydin B, Kan B. Regulation of M2, M3, and M4 muscarinic receptor expression in K562 chronic myelogenous leukemic cells by carbachol. J Recept Signal Transd Res 2011;31:26-32. doi: 10.3109/10799.893.2010.506484
  10. Fleisher TA. Apoptosis. Ann Allergy Asthma Immunol 1997;78:245-9. doi: 10.1016/S1081-1206(10)63176-6
  11. Ashkenazi A, Dixit VM. Death receptors: Signaling and modulation. Science 1998; 281:1305-8. doi: 10.1126/ science.281.5381.1305
  12. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998;281:1309-12. doi: 10.1126/science.281.5381.1309
  13. Hughes D, Mehmet H. Cell proliferation and apoptosis. Advanced Methods. Oxford: Bios Scientific Publishers Limited, 2003.
  14. Wyllie AH, Moms RG, Smith AL, Dunlop D. Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis. J Pathol 1984;142: 67. doi: 10.1002/path.171.142.0112.
  15. Wyllie AH, Kerr JFR, Currie AR. Cell death: the significance of apoptosis. Int Rev Cytol 1980;68:251-306.
  16. Rosenblum K, Futter M, Jones M, E. Hulme C, Bliss T V P, “ERKI/II regulation by the muscarinic acetylcholine receptors in neurons,” J Neurosci 2000;20:977-85. doi: 10.1523/JNEUROSCI.20-03-00977.2000
  17. Yu H, Xia H, Tang Q, et al. Acetylcholine acts through M3 muscarinic receptor to activate the EGFR signaling and promotes gastric cancer cell proliferation. Sci Rep 2017;7:40802. doi: 10.1038/srep40802
  18. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75.
  19. Aydın B, Kan B, Cabadak H. The role of intracellular pathways in the proliferation of human K562 cells that is mediated by muscarinic receptors. Leukemia Res 2013;37: 1144-9. doi: 10.1016/j.leukres.2013.05.018
  20. Schuller HM. Cell type specific, receptor-mediated modulation of growth kinetics in human lung cancer cell lines by nicotine and tobacco-related nitrosamines. Biochem Pharmacol 1989;38:3439-42. doi: 10.1016/0006- 2952(89)90112-3
  21. Maneckjee R, Minna JD. Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines. Proc Natl Acad Sci USA 1990;87:3294-8. doi: 10.1073/pnas.87.9.3294.
  22. Cheng K, Zimniak P, Raufman JP. Transactivation of the epidermal growth factor receptor mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells. Cancer Res 2003;63:6744–50.
  23. Shant J, Cheng K, Marasa BS, Wang JY, Raufman JP. Aktdependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis. Exp Cell Res 2009;315:432-50. doi: 10.1016/j.yexcr.2008.11.003
  24. Peng Z, Heath J, Drachenberg C, Raufman JP, Xie G. Cholinergic muscarinic receptor activation augments murine intestinal epithelial cell proliferation and tumorigenesis. BMC Cancer 2013;13:204. doi: 10.1186/1471-2407-13-204
  25. Raufman JP, Shant J, Xie G, et al. Muscarinic receptor subtype-3 gene ablation and scopolamine butylbromide treatment attenuate small intestinal neoplasia in Apcmin/+ mice. Carcinogenesis 2011;32:1396-402. doi: 10.1093/ carcin/bgr118
  26. Raufman JP, Samimi R, Shah N,et al. Genetic ablation of M3 muscarinic receptors attenuates murine colon epithelial cell proliferation and neoplasia. Cancer Res 2008;68:3573-8. doi: 10.1158/0008-5472.CAN-07-6810
  27. Cheng K, Shang AC, Drachenberg CB, Zhan M, Raufman J P. Differential expression of M3 muscarinic receptors in progressive colon neoplasia and metastasis. Oncotarget 2017;8: 21106-14. doi: 10.18632/oncotarget.15500
  28. Cabadak H, Kücükibrahimoğlu E, Aydin B, Kan B, Gören MZ. Muscarinic receptor- mediated nitric oxide release in a K562 erythroleukaemia cell line. Auton Autacoid Pharmacol 2009;29:109-15. doi: 10.1111/j.1474-8673.2009.00431.x
  29. Cabadak H, Aydin B, Kan B. Muscarinic receptor mediated cAMP response in human K562 chronic myelogenous leukemia cells. Turk J Biochem 2011;36:18-92.
  30. Kodaira M, Kajimura M, Takeuchi K, Lin S, Hanai H, Kaneko E. Functional muscarinic m3 receptor expressed in gastric cancer cells stimulates tyrosine phosphorylation and MAP kinase. J Gastroenterol 1999;34: 163-71. doi: 10.1007/ s005.350.050238
  31. Fujii T, Tsuchiya T, Yamada S, et al. Localization and synthesis of acetylcholine in human leukemic T cell lines. J Neurosci Res 1996;44:66-72. doi: 10.1002/(SICI)1097- 4547(19960401)44:1 3.0.CO;2-G
  32. Kawashima K, Fujii T. Extraneuronal cholinergic system in lymphocytes. Pharmacol Ther 2000;86:29-48. doi: 10.1016/ S0163-7258(99)00071-6.
  33. Shah N, Khurana S, Cheng K, Raufman JP. Muscarinic receptors and ligands in cancer. Am J Physiol Cell Physiol 2009;296:C221-32. doi: 10.1152/ajpcell.00514.2008
  34. Guizetti M, Moore NH, Van DeMark KL, Giordano G, Costa LG. Muscarinic receptor-activated signal transduction pathways involved in the neuritogenic effect of astrocytes in hippocampal neurons. Eur J Pharmacol 2011;659:102-7. doi: 10.1016/j.ejphar.2011.03.019