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Dergiler / Marmara Medical Journal / 2026 / Volume: 35 Issue: 2

The role of dynamic thiol/disulfide homeostasis for the evaluation of oxidative stress in endometriosis patients

Nura Fitnat Topbas Selcukı(UNIVERSITY OF HEALTH SCIENCES SISLI HAMIDIYE ETFAL TRAINING AND RESEARCH HOSPITAL)0000-0002-5749-9987
Pinar Yalcın Bahat(UNIVERSITY OF HEALTH SCIENCES KANUNI SULTAN SULEYMAN TRAINING AND RESEARCH HOSPITAL)
Cihan Kaya(ACIBADEM MEHMET ALI AYDINLAR UNIVERSITY)
Salim Neselıoglu(ANKARA YILDIRIM BEYAZIT UNIVERSITY)0000-0002-0974-5717
Kubra Bagcı(ACIBADEM BODRUM MEDICAL CENTER)0000-0001-6435-0059
Mustafa Goksu(SINOP BOYABAT 75. YEARS STATE HOSPITAL)0000-0002-6389-9178
Meric Kabakcı(UNIVERSITY OF HEALTH SCIENCES SISLI HAMIDIYE ETFAL TRAINING AND RESEARCH HOSPITAL)0000-0002-6956-6753
Ozcan Erel(ANKARA YILDIRIM BEYAZIT UNIVERSITY)0000-0002-2996-3236
Sayfa
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Yayın Tarihi
2022-05-30
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Although, it has been accepted as a potential oxidative stress marker in other chronic inflammatory diseases, its use in determining the systemic oxidative stress level in endometriosis patients is limited.

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Amaç & Hipotez:Objective: To evaluate the role of oxidative stress in endometriosis patients by determining dynamic thiol/disulfide homeostasis and ischemia modified albumin (IMA) levels.
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Temel Bulgular & Veri:Patients and Methods: This prospective case-controlled study was conducted at a tertiary gynecology clinic in Istanbul, Turkey. 86 patients previously diagnosed with endometriosis and persistent endometriomas were included in the study group. 60 patients who visited the clinic during the study period for routine gynecological control were included in the control group.
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Sonuç & Katkı:Although, it has been accepted as a potential oxidative stress marker in other chronic inflammatory diseases, its use in determining the systemic oxidative stress level in endometriosis patients is limited.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Endometriosis · Endometrioma · Dynamic thiol/disulfide homeostasis

Abstract

Objective: To evaluate the role of oxidative stress in endometriosis patients by determining dynamic thiol/disulfide homeostasis and ischemia modified albumin (IMA) levels. Patients and Methods: This prospective case-controlled study was conducted at a tertiary gynecology clinic in Istanbul, Turkey. 86 patients previously diagnosed with endometriosis and persistent endometriomas were included in the study group. 60 patients who visited the clinic during the study period for routine gynecological control were included in the control group. Thiol/disulfide parameters and IMA levels were determined from the serum samples. Results: When the thiol/disulfide parameters were compared between the study and the control group no significant difference was observed (p=0.49). Mean disulfide level in the control group was 18.58 ± 5.73 μmol/L and in the study group was 18.61 ± 7.37 μmol/L. Levels were statistically similar in both groups (p=0.98). In addition, there were no differences between the groups in terms of IMA and albumin levels. Conclusion: The results of this study revealed no significant difference in the dynamic thiol/disulfide homeostasis among the endometriosis patients. Although, it has been accepted as a potential oxidative stress marker in other chronic inflammatory diseases, its use in determining the systemic oxidative stress level in endometriosis patients is limited.

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Bu Makaleye Atıf Yap

Selcukı, N. F. T., Bahat, P. Y., Kaya, C., Neselıoglu, S., Bagcı, K., Goksu, M., Kabakcı, M., Erel, O. (2022). The role of dynamic thiol/disulfide homeostasis for the evaluation of oxidative stress in endometriosis patients. Marmara Medical Journal, Volume: 35 Issue: 2. https://doi.org/10.5472/marumj.1120611

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