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Dergiler / Marmara Medical Journal / 2026 / Volume: 37 Issue: 1

Diagnostic performance between RT-PCR and chest CT in outpatients with clinically suspected COVID-19

Elif Tükenmez Tigen(MARMARA UNIVERSITY)0000-0003-2027-4116
Buket Erturk Sengel(MARMARA UNIVERSITY)0000-0003-2182-4693
Canan Cimsit(MARMARA UNIVERSITY)0000-0002-8971-2076
Hande Perk Gurun(Maltepe District Health Directorate)0000-0001-5180-6213
Çiğdem Apaydın Kaya(MARMARA UNIVERSITY)0000-0003-4786-6760
Volkan Korten(MARMARA UNIVERSITY)0000-0002-9991-814X
Sayfa
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Yayın Tarihi
2024-01-28
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Chest CT might be considered if there is a strong clinical suspicion with repeatedly negative RT-PCR test results, ensuring infection prevention and control measures can be preserved.

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Amaç & Hipotez:Objective: To investigate the diagnostic performance between chest computed tomography (CT) and reverse transcription-polymerase chain reaction (RT-PCR) in outpatients with suspected coronavirus disease 2019 (COVID-19).
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Temel Bulgular & Veri:Patients and Methods: Between March and June 2020, a total of 812 patients with clinically suspected COVID-19 who underwent both chest CT and initial-single RT-PCR on admission to outpatient units were retrospectively enrolled.
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Sonuç & Katkı:Chest CT might be considered if there is a strong clinical suspicion with repeatedly negative RT-PCR test results, ensuring infection prevention and control measures can be preserved.
🔬Tür:Research Article
📍Kapsam:2019 Verileri
⚙️Değişkenler:Chest CT · RT-PCR · COVID-19

Abstract

Objective: To investigate the diagnostic performance between chest computed tomography (CT) and reverse transcription-polymerase chain reaction (RT-PCR) in outpatients with suspected coronavirus disease 2019 (COVID-19). Patients and Methods: Between March and June 2020, a total of 812 patients with clinically suspected COVID-19 who underwent both chest CT and initial-single RT-PCR on admission to outpatient units were retrospectively enrolled. CT severity-score (CT-SS) was calculated and data were matched with PCR results. Results: Of 812 patients, 54% (439/812) had positive RT-PCR results, and 47% (425/812) had a positive chest CT scan. With RT-PCR results as reference, the sensitivity, specificity, accuracy of chest CT in defining COVID-19 infection were 60%, (95% CI 56-65%, 265/439 patients), 57% (95% CI 52-62%, 213/373), 59% (95% CI 55-62%, 478/812), respectively. Three hundred eighty-seven (47%) patients had no CT findings, 380/812 (46.8%) had mild, 45/812 (5.5%) had moderate, and no patients in the severe group Conclusion: Chest CT did not show high sensitivity for the diagnosis of COVID-19 for outpatients. We suggest RT-PCR should be the primary diagnostic tool. Chest CT might be considered if there is a strong clinical suspicion with repeatedly negative RT-PCR test results, ensuring infection prevention and control measures can be preserved.

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Bu Makaleye Atıf Yap

Tigen, E. T., Sengel, B. E., Cimsit, C., Gurun, H. P., Kaya, Ç. A., Korten, V. (2024). Diagnostic performance between RT-PCR and chest CT in outpatients with clinically suspected COVID-19. Marmara Medical Journal, Volume: 37 Issue: 1. https://doi.org/10.5472/marumj.1379916

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