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Dergiler / Addicta: The Turkish Journal on Addictions / 2018 / Cilt: 5 - Sayı: 1

The Association of Single-nucleotide Polymorphisms in Dopamine Receptor D2 Gene with Heroin Dependence in an Iranian Population

Leila Mehdizadeh FANİD
Mohammad Ali HOSSEINPOURFEIZI
Mina ADAMPOURZARE
Adel ABDİ
Sayfa
7–12
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The SNPs of TaqIB (rs1079597) in the DRD2 gene are associated with genetic susceptibility to drug abuse in the Iranian-Azeri population.

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Amaç & Hipotez:Drug addiction is a psychiatric condition known to be associated with the dopaminergic system, which has a vital part in the reward mechanism and etiology of drug addictions in the brain.
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Temel Bulgular & Veri:This study’s aim is to assess the relationship of single-nucleotide polymorphisms in TaqIB and TaqIA of the DRD2 gene with the risk of drug dependence in a Northwestern Iranian population. 83 drug-dependent subjects and 83 healthy subjects have been recruited in this study.
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Sonuç & Katkı:The SNPs of TaqIB (rs1079597) in the DRD2 gene are associated with genetic susceptibility to drug abuse in the Iranian-Azeri population.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Drug addiction is a psychiatric condition known to be associated with the dopaminergic system, which has a vital part in the reward mechanism and etiology of drug addictions in the brain. This study’s aim is to assess the relationship of single-nucleotide polymorphisms in TaqIB and TaqIA of the DRD2 gene with the risk of drug dependence in a Northwestern Iranian population. 83 drug-dependent subjects and 83 healthy subjects have been recruited in this study. After genomic DNA isolation, two single-nucleotide polymorphisms, TaqIA (rs1800497) and TaqIB (rs1079597), were genotyped using the PCR-RFLP technique. Data analysis has been performed using the Statistical Package for the Social Sciences (SPSS-24) software for the chi- square (X 2 ) test. No significant difference was detected in the TaqIA polymorphism between the control and case study groups (p > .05). In the case group, the TaqIB polymorphism was higher than the control group, showing a statistically significant variation (p < .05). The SNPs of TaqIB (rs1079597) in the DRD2 gene are associated with genetic susceptibility to drug abuse in the Iranian-Azeri population.

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Bu Makaleye Atıf Yap

FANİD, L. M., HOSSEINPOURFEIZI, M. A., ADAMPOURZARE, M., ABDİ, A. (2018). The Association of Single-nucleotide Polymorphisms in Dopamine Receptor D2 Gene with Heroin Dependence in an Iranian Population. Addicta: The Turkish Journal on Addictions, Cilt: 5 - Sayı: 1, 7–12. https://ajindex.com/articles/127426

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Kaynakça (10)

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