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Dergiler / Hacettepe Journal of Biology and Chemistry / 2026 / Volume: 40 Issue: 2

Biyomühendislik Fonksiyonel Kopolimerleri. XX. Yeni Antikanser Aktif Poli maleik anhidrid-alt-2- vinil-1,3-dioxolan ve Organoboron Amid-Ester Dallanmış Türevleri

Bioengineering Functional Copolymers. XX. Synthesis of Novel Anticancer Active Poly maleic anhydride-alt-2-vinyl-1,3-dioxolane and its Organoboron Amide-Ester Branched Derivatives ​

Gülten Kahraman(Turkish Atomic Energy Authority (TAEK), Sarayköy Nuclear Research and Training Center, Ankara, Turkey)
Mustafa Türk(Kırıkkale University, Department of Biology, Faculty of Arts and Sciences, Yahşihan, Kırıkkale, Turkey)
Zakir M.o. Rzayev(Hacettepe University, Division of Nanotechnology and Nanomedicine, Institute of Science and Engineering, Ankara, Turkey)
Ernur A. Söylemez(Hacettepe University, Division of Nanotechnology and Nanomedicine, Institute of Science and Engineering, Ankara, Turkey)
Serpil Oğuztüzün(Kırıkkale University, Department of Biology, Faculty of Arts and Sciences, Yahşihan, Kırıkkale, Turkey)
Sayfa
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Yayın Tarihi
2012-04-01
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

İyonize olabilen, hidrofilik/hidrofobik, organobor, anhidrit-karboksil-amid-ester-eter gibi gruplar içeren bu kopolimerlerin HeLa hücrelerine sitotoksik etkisi araştırılmış ve organobor-PEO kopolimer < poli MAalt-VDO < organobor kopolimer sırasında olduğu belirlenmiştir

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Y eni biyomühendislik alternatif kopolimerinin ve organobor amid ve a-hidroksi-w-metoksi-poli etilen oksit PEO ile dallanmış türevlerinin sentezi, 1 Seçilen reaksiyon şartlarında homopolimerleşmeyen maleik anhidriti MA ve 2-vinil-1,3-dioksolan VDO monomerlerinin kompleks-radikal alternatif kopolimerizasyonu, 2 sentezlenenpoli MA-alt-VDO makromoleküllerinin 2-amino-etildifenilboronat ile amidolizi ve 3 PEO ile esterleşmesi yöntemleri kulllanarak gerçekleştirilmiştir.
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Temel Bulgular & Veri:Monomerlerin kompleks oluşumu K ve kopolimerleşme sabitleri r1 ve r2 , çok fonksiyonel gruplar içeren kopolimerlerin yapısı, içeriği ve ısısal özellikleri kimyasal analiz alkali titrasyon , FTIR-ATR and NMR spektroskopisi ve TGA-DSC ile karakterize edilmiştir.
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Sonuç & Katkı:İyonize olabilen, hidrofilik/hidrofobik, organobor, anhidrit-karboksil-amid-ester-eter gibi gruplar içeren bu kopolimerlerin HeLa hücrelerine sitotoksik etkisi araştırılmış ve organobor-PEO kopolimer < poli MAalt-VDO < organobor kopolimer sırasında olduğu belirlenmiştir
🔬Tür:Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Synthesis · Alternating copolymer · Amidolysis

Özet

Y eni biyomühendislik alternatif kopolimerinin ve organobor amid ve a-hidroksi-w-metoksi-poli etilen oksit PEO ile dallanmış türevlerinin sentezi, 1 Seçilen reaksiyon şartlarında homopolimerleşmeyen maleik anhidriti MA ve 2-vinil-1,3-dioksolan VDO monomerlerinin kompleks-radikal alternatif kopolimerizasyonu, 2 sentezlenenpoli MA-alt-VDO makromoleküllerinin 2-amino-etildifenilboronat ile amidolizi ve 3 PEO ile esterleşmesi yöntemleri kulllanarak gerçekleştirilmiştir. Monomerlerin kompleks oluşumu K ve kopolimerleşme sabitleri r1 ve r2 , çok fonksiyonel gruplar içeren kopolimerlerin yapısı, içeriği ve ısısal özellikleri kimyasal analiz alkali titrasyon , FTIR-ATR and NMR spektroskopisi ve TGA-DSC ile karakterize edilmiştir. İyonize olabilen, hidrofilik/hidrofobik, organobor, anhidrit-karboksil-amid-ester-eter gibi gruplar içeren bu kopolimerlerin HeLa hücrelerine sitotoksik etkisi araştırılmış ve organobor-PEO kopolimer < poli MAalt-VDO < organobor kopolimer sırasında olduğu belirlenmiştir

Abstract

Novel bioengineering alternating copolymer and its organoboron amide and a-hydroxy-w- methoxypoly ethylene oxide PEO branched derivatives were synthesized by 1 complex-radical alternating copolymerization of two non-homopolymerizable in chosen reaction conditions monomers such as maleic anhydride MA and 2-vinyl-1,3-dioxolane VDO , 2 amidolysis of synthesized poly MA-alt-VDO with 2-aminoethyldiphenylboronate and 3 esterification-grafting of organoboron copolymer with PEO. The complex-formation Kc and the monomer reactivity ratios r1 and r2 copolymerization constants , structure and composition of the synthesized copolymers were characterized by chemical alkali titration , FTIR-ATR and NMR spectroscopy, TGA-DSC thermal analysis methods. Cytotoxicity found as having an order as organoboron branched PEO copolymer < poly MA-alt-VDO < organoboron copolymer of these novel copolymers containing a combination of ionizable, hydrophilic/hydrophobic, organoboron, carboxyl-amide-ester-ether groups, toward HeLa cells was investigated.

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Bu Makaleye Atıf Yap

Kahraman, G., Türk, M., Rzayev, Z. M., Söylemez, E. A., Oğuztüzün, S. (2012). Biyomühendislik Fonksiyonel Kopolimerleri. XX. Yeni Antikanser Aktif Poli maleik anhidrid-alt-2- vinil-1,3-dioxolan ve Organoboron Amid-Ester Dallanmış Türevleri. Hacettepe Journal of Biology and Chemistry, Volume: 40 Issue: 2. https://ajindex.com/articles/1271008

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