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Dergiler / Hacettepe Journal of Biology and Chemistry / 2026 / Volume: 51 Issue: 2

EVALUATION AND COMPARISON OF THE ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF SOME AMINO ACID METHYL ESTERS

Tuğçe Deniz Karaca(GAZİ ÜNİVERSİTESİ, SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU)0000-0002-7471-1759
Hüseyin Balcı(GEBZE TECHNICAL UNIVERSITY)0000-0002-8778-4586
Arzu Aysan(GEBZE TECHNICAL UNIVERSITY)0000-0001-7217-3347
Sayfa
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Yayın Tarihi
2023-04-01
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

For this reason, it is thought that the results obtained will contribute to research on new synthesizable compounds based on amino acid esters and studies on drug development.

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Amaç & Hipotez:In this study, the antibacterial and cytotoxic activities of some amino acid methyl esters (L-methionine, L-phenylalanine, L-histidine, L-lysine, L-tryptophan, and L-tyrosine) were investigated.
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Temel Bulgular & Veri:The effect of amino acid methyl ester compounds on antibacterial performance was determinated against Gram-negative and Gram-positive bacteria.
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Sonuç & Katkı:For this reason, it is thought that the results obtained will contribute to research on new synthesizable compounds based on amino acid esters and studies on drug development.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Amino Acid Esters · Antibacterial Activity · Antiproliferative Activity

Abstract

In this study, the antibacterial and cytotoxic activities of some amino acid methyl esters (L-methionine, L-phenylalanine, L-histidine, L-lysine, L-tryptophan, and L-tyrosine) were investigated. The effect of amino acid methyl ester compounds on antibacterial performance was determinated against Gram-negative and Gram-positive bacteria. The effect of amino acid esters on cell viability was investigated against cancerous and non-cancerous cell lines using the MTS assay. The results showed the substances had low antimicrobial effect on both Gram-negative and Gram-positive bacteria. In addition, it was found that the studied substances did not have a toxic effect on cell growth in non-cancerous cells. For this reason, it is thought that the results obtained will contribute to research on new synthesizable compounds based on amino acid esters and studies on drug development.

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Bu Makaleye Atıf Yap

Karaca, T. D., Balcı, H., Aysan, A. (2023). EVALUATION AND COMPARISON OF THE ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF SOME AMINO ACID METHYL ESTERS. Hacettepe Journal of Biology and Chemistry, Volume: 51 Issue: 2. https://doi.org/10.15671/hjbc.1183477

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Kaynakça (26)

  1. Nanayakkara, A. K., Boucher, H. W., Fowler Jr, V. G., Jezek, A., Outterson, K., & Greenberg, D. E., Antibiotic resistance in the patient with cancer: Escalating challenges and paths forward, CA: A Cancer Journal for Clinicians, 71(6) (2021) 488-504.
  2. Mancuso, G., Midiri, A., Gerace, E., & Biondo, C., Bacterial antibiotic resistance: The most critical pathogens, Pathogens,10 (10) (2021) 1310.
  3. Fair, R.J., Tor, Y., Antibiotics and bacterial resistance in the 21st century, Perspect. Med. Chem., (2014) 6 25-64.
  4. Song, J., What’s new on the antimicrobial horizon?, Int J Antimicrob Agents, 32 (2008) 207-13.
  5. Chen, S., Li, L., Zhao, C., Zheng, J., Surface hydration: Principles and applications toward low-fouling/nonfouling biomaterials, Polymer, 51 (2010) 5283−5293.
  6. Sanchez. L., Martinez, V., Infante, M.R., Mitjans, M., Vinardell, M.P., Haemolysis and antihaemolysis induced by amino acid-based surfactants, Toxicol Lett, 169 (2007) 177-84.
  7. Sarma, R., Alva, K.S., Marx, K.A., Tripathy, S.K., Akkara, J.A., Kaplan, D.L., Enzymatic polymer-ization of amphiphillic alkyl tyrosine derivatives from emulsions, Mater Sci Eng C, 4 (1996) 189–92.
  8. Perez, L., Pinazo, A., Garcia, M.T., Moran, M.C., Infante, M.R., Monoglyceride surfactants from arginine: synthesis and biological properties, New J Chem, 28 (2004) 1326-34.
  9. Perez, L., Pinazo, A., Tereza, Garcia M., Lozano, M., Manresa, A., Angelet, M., et al. Cationic surfactants from lysine: synthesis, micellisation and biological evaluation, Eur J Med Chem, 44 (2009) 1884-1892.
  10. Balouiri, M., Sadiki, M., Ibnsouda, S.K., Methods for in vitro evaluating antimicrobial activity, A review. Journal of Pharmaceutical Analysis, 6 (2) (2016) 71-79.
  11. Joondan, N., Jhaumeer-Laulloo, S., Caumul, P., A study of the antibacterial activity of l-Phenylalanine and l-Tyrosineesters in relation to their CMCs and their interactions with1,2-dipalmitoyl-sn-glycerol-3-phosphocholine, DPPC as model membrane, Microbiological Research, 169 (2014) 675-685.
  12. Malanovic, N., Lohner, K., Gram-positive bacterial cell envelopes: The impact on the activity of antimicrobial peptides, Biochimica et Biophysica Acta (BBA)– Biomembranes, 1858 (5) (2016) 936-946.
  13. Silhavy, T.J., Kahne, D., Walker, S., The bacterial cell envelope, Cold Spring Harbor Perspectives in Biology, 2 (5) (2010) 414.
  14. Pinazo, A., Manresa, M.A., Marques, A.M., Bustelo, M., Espuny, M.J., Pérez, L., Amino acid–based surfactants: New antimicrobial agents, Advances in Colloid and Interface Science 228 (2016)17-39.
  15. Hameurlaine, A., El-Sayed, W.A., Abdel-Rahman, A.H., Amino acid derivatives, IX [1]: synthesis and antimicrobial evaluation of α-amino acid esters bearing a tryptophane side chain, Monatshefte für Chemie-Chemical Monthly, 139 (2008) 1507–1511.
  16. Siebert, A., Wysocka, M., Krawczyk, B., Cholewiński, G., Rachoń, J., Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid, European Journal of Medicinal Chemistry, 143 (2018) 646-655.
  17. Wanders, D., Hobson, K., Ji, X., Methionine restriction and cancer biology, Nutrients, 12(3) (2020) 684.
  18. Hung, M.H., Lee, J.S., Ma, C. et al., Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma, Nature Communications, (2021) 1455.
  19. Chau, W.K., Law, P., Effect of L-Phenylalanine methyl ester on the colony formation of hematopoietic progenitor cells from human bone marrow, The International Journal Of Cell Cloning, 9 ( 3) (1991) 211–219.
  20. Escobar-Resendiz, R., Reyes-Esparza, J., Ortega,Lourdes I., Rodriguez-Fragoso, L., evaluation of cytotoxic effect of l-histidine methyl ester hydrochloride of amphotericin-B (A21) on tumoral cells, The FASEB Journal, 33 (2019) 515.
  21. Kandekar, U., Pujari, R., Chaudhari, P., et al, Nanocarriers for breast cancer: Advanced perspective, Hacettepe University Journal of the Faculty of Pharmacy, 41(3) (2021) 179-195.
  22. Jonas, A.J., Butler, I.J., Circumvention of defective neutral amino acid transport in Hartnup disease using tryptophan ethyl ester, J Clin Invest, 84 (1) (1989) 200-4.
  23. Jadhav, A., Liang, W., Balsevich, J., Bastin, G., Kroetsch, J., Heximer, S., Backx, P.H., Gopalakrishnan, V., L-tryptophan ethyl ester dilates small mesenteric arteries by inhibition of voltage-operated calcium channels in smooth muscle, Br J Pharmacol, 166 (1) (2012) 232-42.
  24. Oliyai, R., Stella, V.J., Prodrugs of peptides and proteins for improved formulation and delivery, Annu Rev Pharmacol Toxicol 32 (1993) 521–544.
  25. Carlsson, P.A.E., Corrodi, H.R., Aktiebolaget Hassle, Treatment of Parkinson’s disease. US Patent, (1975) 19730820.
  26. Sztanke, K., Maziarka, A., Osinka, A., Sztanke, M., An insight into synthetic Schiff bases revealing antiproliferative activities in vitro, Bioorganic & Medicinal Chemistry, Volume 21, Issue 13 (1975) 3648-3666.