Dergiler / Bakırköy Tıp Dergisi / 2020 / Cilt: 16 - Sayı: 1

Bone Mineral Density in Patients With Early- Onset Rheumatoid Arthritis§

Erken Başlangıç Romatoid Artritindeki Hastalarının Kemik Mineral Yoğunluğu

Sayfa
44–48
DOI
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Dual energy x-ray absorptiometry is an important tool to assess BMD in early RA patients.

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Amaç & Hipotez:Objective: Rheumatoid arthritis (RA) is a chronic inflammatory and destructive joint disease that affects 0.5-1% of the world’s population and commonly leads to significant disability and consequent impairment of quality of life.
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Temel Bulgular & Veri:Osteoporosis is an early and common feature in RA and occurs during the course of the disease as extra-articular manifestation of rheumatoid arthritis, which may result in increased risk of fractures, morbidity, and mortality.
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Sonuç & Katkı:Dual energy x-ray absorptiometry is an important tool to assess BMD in early RA patients.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objective: Rheumatoid arthritis (RA) is a chronic inflammatory and destructive joint disease that affects 0.5-1% of the world’s population and commonly leads to significant disability and consequent impairment of quality of life. Osteoporosis is an early and common feature in RA and occurs during the course of the disease as extra-articular manifestation of rheumatoid arthritis, which may result in increased risk of fractures, morbidity, and mortality. The aim of this study was to evaluate changes in bone mineral density in patients with early- onset rheumatoid arthritis including its correlation with disease activity. Method: Ther study was performed with 50 patients diagnosied as early- onset rheumatoid made less than two years ago n the Private Clinic “Rheuma”, who fulfilled the diagnostic criteria of American College of Rheumatology/ European League Against Rheumatism and 30 healthy volunteers as controls. Bone mineral density of these patients was measured at lumbar spine and hip by using dual energy x-ray absorptiometry scan (DEXA Stratos 800). Demographic and clinical data including age, gender, BMI, menstrual status, disease duration, laboratory tests, and disease activity scale (DAS28) scores were collected. Results: From a total of 50 patients with RA, 36 were females and 14 were males with an overall mean age of 27-57 (33.7±7.87 years), fulfilling ACR/EULAR Criteria. The patients with RA, had osteoporosis (16%), osteopenia (65%) and normal BMD (30%) values. In the group of RA patients with osteoporosis had higher disease activity scores (DAS-28) without any statistically significant correlation compared to RA patients with normal BMD values or osteopenia. Conclusion: Patients with RA are more likely to have bone loss compared to normal age subjects. Lower BMD values were found in patients at earlier stage of the rheumatoid arthritis with higher disease activity. Dual energy x-ray absorptiometry is an important tool to assess BMD in early RA patients.

Abstract

Amaç: Romatoid artrit (RA), dünyadaki popülasyonun% 0,5-1’ini etkileyen ve genellikle yaşam kalitesinde önemli bir sakatlığa ve bunun sonucunda bozulmaya neden olan kronik bir enflamatuar ve yıkıcı eklem hastalığıdır. Osteoporoz RA’da erken ve yaygın bir özelliktir. Hastalığın seyri sırasında romatoid artritin ekstra-artiküler belirtisi olarak ortaya çıkar ve bu da kırık, morbidite ve mortalite riskinde artışa neden olabilir. Bu çalışma, erken başlangıçlı romatoid artritli hastalarda hastalık aktivitesi ile korelasyonu da dahil olmak üzere kemik mineral yoğunluğu değişikliklerini değerlendirmeyi amaçlamaktadır. Yöntem: Örnek erken başlangıçlı romatoid olan 50 hastadan oluşmaktadır. Özel Klinik “Romatoloji”de iki yıldan daha az olan artrit, Romatoloji / Amerikan Romatoloji Koleji / Romatizmaya Karşı Teşhis Kriterleri ve 30 sağlıklı gönüllü kontrolör olarak yerine getirildi. Bu hastaların kemik mineral yoğunluğu lomber omurga ve kalçada çift enerjili x-ışını absorpsiyometri taraması (DEXA Stratos 800) ile ölçüldü. Demografik ve klinik veriler yaş, cinsiyet, BKİ, adet durumu, hastalık süresi, laboratuvar testleri ve hastalık aktivite ölçeği (DAS28) gibi toplandı. Bulgular: RA’lı toplam 50 hastadan 36’sı kadın, 14’ü ACR / EULAR kriterlerini karşılayan ortalama yaş 27-57 (33.7±7.87 yıl) idi. RA’lı hasta grubunda % 16’sında osteoporoz, %65’inde osteopeni ve %30’unda normal KMY vardı. Osteoporozlu RA hasta grubunda daha yüksek hastalık aktivite skoru (DAS-28) bulundu ve normal BMD ya da osteopeni olan RA hastalarına göre istatistiksel olarak anlamlı bir ilişki yoktu. Sonuç: RA hastalarının normal yaştaki deneklere göre kemik kaybı yaşama olasılığı daha yüksektir. Bulgular, romatoid artritin erken evrelerinde, hastalık aktivitesi yüksek olan hastalarda düşük KMY olduğunu göstermektedir. Erken RA hastalarında KMY’yi değerlendirmek için çok önemli bir araç çift enerjili x-ışını absorpsiyometrisi olarak kabul edilir.

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Bu Makaleye Atıf Yap

REXHEPİ, S., REXHEPİ, M., REXHEPİ, B., MEKA, V. S., MAHMUTAJ, V. (2020). Bone Mineral Density in Patients With Early- Onset Rheumatoid Arthritis§. Bakırköy Tıp Dergisi, Cilt: 16 - Sayı: 1, 44–48. https://ajindex.com/articles/125371

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