ACE 2 in the Context of COVID 19 – An Opportunity for us or the Virus

Kaynakça (13)

1. Tipnis SR, HooperNM, Hyde R, Karran E, Christie G, Turner AJ. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril insensitive carboxypeptidase. J Biol Chem 2000;275:33238–43
2. Douglas GC, O’Bryan MK, Hedger MP, Lee DK, Yarski MA, Smith AI & Lew RA. The novel angiotensin converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis. Endocrinology 2004;145:4703–11
3. Hamming I, Timens W, Bulthuis M.L, Lely A.T, Navis G. and van Goor H. Tissue distribution of ace2 protein, the functional receptor for sars coronavirus. A first step in understanding sars pathogenesis. J. Pathol 2004;203:631–7
4. Franks TJ, PY Chong, P Chui, JR Galvin, RM Lourens, AH Reid, et al. Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore. Hum. Pathol 2003;34:743–8
5. Nicholls J M, L L Poon, K C Lee, W F Ng, S T Lai, C Y Leung, et al. Lung pathology of fatal severe acute respiratory syndrome. Lancet 2003;361:1773–8
6. Du L, He Y, Zhou Y, Liu S, Zheng B.J. and Jiang S. The spike protein of sars-cov–a target for vaccine and therapeutic development. Nat. Rev. Microbiol 2009;7:226–36
7. Hofmann H, P. Krzysztof, L. van der Hoek, M. Geier, B. Berkhout, and S. Pohlmann. 2005. Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry. Proc Natl Acad Sci USA 102:7988–93
8. Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. Lancet 2020;395:565–74
9. Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, et al. (2020) Cryo-em structure of the 2019-ncov spike in the prefusion conformation. Science, https://doi.org/10.1126/ science.abb2507
10. Yumiko Imai, Keiji Kuba and Josef M. Penninger. The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice. Exp Physiol 93.5 pp 543–548
11. Imai Y, Kuba K, Rao S, Huan Y, Guo F, Guan B, et al. Angiotensinconverting enzyme 2 protects from severe acute ung failure. Nature 2005;436:112–6
12. Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus- induced lung injury. Nature Medicine 2005;11:875–9
13. Wysocki J, Ye M, Rodriguez E, Gonzalez-Pacheco FR, Barrios C, Evora K, et al. Targeting the degradation of angiotensin ii with recombinant