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Yasadışı Maddelerin Tespı̇tı̇ içı̇n Aptamer Tabanlı Elektrokı̇myasal Sensörler: Son On Yılın Adlı̇ Uygulamaları

APTAMER-BASED ELECTROCHEMICAL SENSORS FOR ILLICIT DRUG DETECTION: FORENSIC APPLICATIONS IN THE LAST DECADE YEARS

Ezgi Emen(EGE ÜNİVERSİTESİ, MADDE BAĞIMLILIĞI, TOKSİKOLOJİ VE İLAÇ BİLİMLERİ ENSTİTÜSÜ)0000-0002-4598-5080
Fatma Nil Ersoy Ertaş(EGE ÜNİVERSİTESİ, KİMYA FAKÜLTESİ, KİMYA PR.)0000-0001-8982-9621
Pınar Kara Kadayıfçılar(EGE UNIVERSITY, FACULTY OF PHARMACY, PHARMACY PR.)0000-0001-5029-9256
Serap Akgur(EGE ÜNİVERSİTESİ, MADDE BAĞIMLILIĞI, TOKSİKOLOJİ VE İLAÇ BİLİMLERİ ENSTİTÜSÜ, BAĞIMLILIK TOKSİKOLOJİSİ ANABİLİM DALI)0000-0001-9638-2311
Sayfa
505–520
Yayın Tarihi
2025-08-31
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bu derleme, POC (Point of Care) uygulamaları için aptasensörlerin hassasiyetini, seçiciliğini ve uygulanabilirliğini artırmak için daha fazla araştırma ve geliştirme ihtiyacını vurgulamaktadır.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Bu kısma makalenizin Türkçe özetini yerleştirmeniz gerekmektedir.
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Temel Bulgular & Veri:Öz, 10 punto büyüklüğünde, iki yana yaslı ve 250 sözcüğü geçmeyecek (500-1000 karakter) şekilde yazılmalıdır.
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Sonuç & Katkı:Bu derleme, POC (Point of Care) uygulamaları için aptasensörlerin hassasiyetini, seçiciliğini ve uygulanabilirliğini artırmak için daha fazla araştırma ve geliştirme ihtiyacını vurgulamaktadır.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Yasadışı maddelerin analizi · Aptamer · Elektrokimyasal aptasensörler

Özet

Bu kısma makalenizin Türkçe özetini yerleştirmeniz gerekmektedir. Öz, 10 punto büyüklüğünde, iki yana yaslı ve 250 sözcüğü geçmeyecek (500-1000 karakter) şekilde yazılmalıdır. Dünyada yasadışı maddelerin kullanımı toplumların güvenliğini tehdit eden küresel bir sorun olarak karşımıza çıkmaktadır. Yasadışı maddelerin ve biyolojik materyallerdeki ilgili metabolitlerini hızlı ve güvenilir bir şekilde taramak için çeşitli seçici tekniklere ihtiyaç duyulmaktadır. Biyosensörler, biyolojik tanıma unsurlarını dönüştürücülerle birleştiren entegre cihazlardır. Aptasensörler, hedef moleküllere olağanüstü özgüllükleri ve yüksek bağlanma afiniteleri ile bilinen aptamer tabanlı afinite biyosensörleridir ve sağlık, gıda, çevre ve adli uygulamalar alanında önemli ilerlemeler sağlamaktadır. Birçok aptasensör geleneksel immünokimyasal aptamer ile neredeyse aynıdır ve aptamerler antikorlara benzerler. Elektrokimyasal aptasensörler, elektrokimyasal transdüksiyon ile entegre edilmiş biyolojik tanıma için aptamerlerdir. Son on yılda esrar, opioidler ve amfetamin türevleri de dahil olmak üzere yasadışı maddelerin tespiti için elektrokimyasal aptamerlerin kullanımı üzerine yapılan son gelişmeler bu çalışmada tartışılmaktadır. Bu çalışma, mevcut teknolojileri ve zorlukları sunmayı ve literatürde ele alınabilecek boşlukları vurgulamayı amaçlamaktadır. Bu derleme, POC (Point of Care) uygulamaları için aptasensörlerin hassasiyetini, seçiciliğini ve uygulanabilirliğini artırmak için daha fazla araştırma ve geliştirme ihtiyacını vurgulamaktadır.

Abstract

Illicit drugs are a global problem, and a variety of selective techniques are urgently needed to detect drugs of interest. Biosensors are integrated devices that combine biological recognition elements with transducers. Aptasensors are aptamer-based affinity biosensors, which are known for their exceptional specificity and high binding affinity to target molecules, and are providing significant advancements in the field of health, food, environmental, and forensic applications. Many aptasensors are nearly identical to conventional immunochemical aptamer, and aptamers are analogous to antibodies. Electrochemical aptasensors are aptamer for biological recognition integrated with electrochemical transduction. Recent studies on the use of electrochemical aptasensors for the detection of illicit drugs, including cannabis, opioids and amphetamine derivatives, in the last decade are discussed in this section. This section aims to present current technologies and challenges, and highlights gaps in the literature that can be addressed. This review emphasises the need for further research and development to improve the sensitivity, selectivity and applicability of aptasensors for point-of-care applications.

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Bu Makaleye Atıf Yap

Emen, E., Ertaş, F. N. E., Kadayıfçılar, P. K., Akgur, S. (2025). Yasadışı Maddelerin Tespı̇tı̇ içı̇n Aptamer Tabanlı Elektrokı̇myasal Sensörler: Son On Yılın Adlı̇ Uygulamaları. Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Cilt: 18 Sayı: 2, 505–520. https://doi.org/10.18185/erzifbed.1616754

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