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Dergiler / Turkish Journal of Veterinary and Animal Sciences / 2017 / Cilt: 41 - Sayı: 6

Antiinflammatory effect of herbal preparations on adjuvant arthritis in rats

Laimis AKRAMAS
Laima LEONAVICIENE
Ruta BRADUNAITE
Audrius VASILIAUSKAS
İrena DUMALAKIENE
Danguole ZABULYTE
Teresa NORMANTIENE
İrena JONAUSKIENE
Dalia VAITKIENE
Sayfa
748–756
Yayın Tarihi
2017-12-20
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Both preparations could be potential preventive or therapeutic candidates for the treatment of autoimmune processes in combination with other drugs.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:The present study aimed to investigate the antiinflammatory effects of 2 herbal extracts (CDS and CDSM) in rats with experimental adjuvant arthritis (AA).
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Temel Bulgular & Veri:Joint swelling, development of polyarthritis, blood indices, pro/antioxidant activity, and proinflammatory cytokine IL-17 in blood serum, as well as the liver and paw histopathology and histochemistry, were assessed.
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Sonuç & Katkı:Both preparations could be potential preventive or therapeutic candidates for the treatment of autoimmune processes in combination with other drugs.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Adjuvant arthritis · herbal extracts · antioxidant activity

Abstract

The present study aimed to investigate the antiinflammatory effects of 2 herbal extracts (CDS and CDSM) in rats with experimental adjuvant arthritis (AA). Joint swelling, development of polyarthritis, blood indices, pro/antioxidant activity, and proinflammatory cytokine IL-17 in blood serum, as well as the liver and paw histopathology and histochemistry, were assessed. Oral injections of extracts showed an antiinflammatory effect analogous to that of diclofenac (DF), improved blood indices and suppressed level of IL-17, significantly diminished joint swelling, and histological changes in the joints. Increase in CAT activity and AOA and reduction in lipid peroxidation was noted. The preparations did not show toxic effects on the liver. The obtained results suggest that the prophylactic use of CDS and CDSM have a significant effect on slowing AA progression, similar to the effect of DF. Both preparations could be potential preventive or therapeutic candidates for the treatment of autoimmune processes in combination with other drugs.

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Bu Makaleye Atıf Yap

AKRAMAS, L., LEONAVICIENE, L., BRADUNAITE, R., VASILIAUSKAS, A., DUMALAKIENE, İ., ZABULYTE, D., NORMANTIENE, T., JONAUSKIENE, İ., VAITKIENE, D. (2017). Antiinflammatory effect of herbal preparations on adjuvant arthritis in rats. Turkish Journal of Veterinary and Animal Sciences, Cilt: 41 - Sayı: 6, 748–756. https://ajindex.com/articles/122467

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Kaynakça (10)

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