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Dergiler / Turkish Journal of Veterinary and Animal Sciences / 2005 / Cilt: 29 - Sayı: 5

A Study on the Effects of Levamisole on the Immune System of Rainbow Trout (Oncorhynchus mykiss, Walbaum)

Ünal İSPİR
Mustafa DÖRÜCÜ
Sayfa
1169–1176
Yayın Tarihi
2005-05-01
DOI
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However, there were considerable increases in the other immune parameters and significant differences were detected between the control and experimental groups (P < 0.05, P < 0.01, P < 0.001).

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Amaç & Hipotez:The effects of levamisole on the specific and non-specific immune mechanisms of rainbow trout (Oncorhynchus mykiss, Walbaum) were examined.
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Temel Bulgular & Veri:The weight of the 60 fish used (30 in the control group and 30 in the experimental group) in this study was 99.4-216.0 g.
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Sonuç & Katkı:However, there were considerable increases in the other immune parameters and significant differences were detected between the control and experimental groups (P < 0.05, P < 0.01, P < 0.001).
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Immunomodulation · immunity · levamisole

Özet

The effects of levamisole on the specific and non-specific immune mechanisms of rainbow trout (Oncorhynchus mykiss, Walbaum) were examined. The weight of the 60 fish used (30 in the control group and 30 in the experimental group) in this study was 99.4-216.0 g. After injecting 5 mg kg-1 of levamisole intraperitonally, blood was taken from the heart of 30 anesthetized fish and hematocrit, leucocrit, leucocyte level, glass-adherent Nitroblue tetrazolium (NBT) positive cell activation, NBT activities, phagocytic activity, potential killing activities of neutrophyl and monocytes, myeloperoxidase production (MPO), immunoglobulin, lysozyme and ceruloplasmin (Cp) activity were determined on days 3, 7, 10 and 14. The same procedure was conducted on a control group. No differences were found in the levels of hematocrit, leucocrit or immunuglobulin between the control and experimental groups (P > 0.05). However, there were considerable increases in the other immune parameters and significant differences were detected between the control and experimental groups (P < 0.05, P < 0.01, P < 0.001).

Abstract

The effects of levamisole on the specific and non-specific immune mechanisms of rainbow trout (Oncorhynchus mykiss, Walbaum) were examined. The weight of the 60 fish used (30 in the control group and 30 in the experimental group) in this study was 99.4-216.0 g. After injecting 5 mg kg-1 of levamisole intraperitonally, blood was taken from the heart of 30 anesthetized fish and hematocrit, leucocrit, leucocyte level, glass-adherent Nitroblue tetrazolium (NBT) positive cell activation, NBT activities, phagocytic activity, potential killing activities of neutrophyl and monocytes, myeloperoxidase production (MPO), immunoglobulin, lysozyme and ceruloplasmin (Cp) activity were determined on days 3, 7, 10 and 14. The same procedure was conducted on a control group. No differences were found in the levels of hematocrit, leucocrit or immunuglobulin between the control and experimental groups (P > 0.05). However, there were considerable increases in the other immune parameters and significant differences were detected between the control and experimental groups (P < 0.05, P < 0.01, P < 0.001).

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Bu Makaleye Atıf Yap

İSPİR, Ü., DÖRÜCÜ, M. (2005). A Study on the Effects of Levamisole on the Immune System of Rainbow Trout (Oncorhynchus mykiss, Walbaum). Turkish Journal of Veterinary and Animal Sciences, Cilt: 29 - Sayı: 5, 1169–1176. https://ajindex.com/articles/122427

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Kaynakça (15)

  1. Sakai, M.: Current research status of fish immunostimulants. Aquaculture, 1999; 172: 63-92.
  2. Siwicki, A.K., Anderson, D.P., Rumsey, G.L.: Dietary intake of immunostimulants by rainbow trout affects non-specific immunity and protection against furunculosis. Vet. Immunol. Immunopathol., 1994; 41: 125-139.
  3. Stoskopf, M.K.: Fish Medicine. W. B. Saunders, Philadelphia. 1993.
  4. Findlay, V.L., Munday, B.L.: Immunomodulatory effects of levamisole on the nonspecific immune system of Atlantic salmon, Salmo salar L. J. Fish. Dis., 2000; 23: 369-378.
  5. Jeney, G., Anderson, D.P.: Glucan injection or bath exposure given alone or in combination with a bacterin enhance the non – specific defence mechanisms in rainbow trout (Oncorhynchus mykiss). Aquaculture, 1993; 116: 315-329.
  6. Kitao T., Yoshida Y.: Effect of an immunopotentiator on Aeromonas salmonicida infection in rainbow trout (Salmo gairdneri). Vet. Immunol. Immunopathol., 1986; 12: 287-296.
  7. Sakai, M., Otubo, T, Atsuta, S., Kobayashi, M.: Enhancement of resistance to bacterial infection in rainbow trout, Oncorhynchus mykiss (Walbaum), by oral administration of bovine lactoferrin. J. Fish Dis., 1993; 16: 239-247.
  8. Siwicki, A.K.: Immunomodulating activity of levamisole in carp spawners, Cyprinus carpio L. J. Fish Biol., 1987; 31 (Supp. A): 245-246.
  9. Siwicki, A.K.: Immunostimulating influence of levamisole on non- specific immunity in carp, Cyprinus carpio L. Dev. Comp. Immunol., 1989; 13: 87-91.
  10. Kodama, H., Hirota, Y., Mukamoto, M., Baba, T., Azuma, I.: Activation of rainbow trout (Oncorhynchus mykiss) phagocytes by Muramyl dipeptide. Dev. Comp. Immunol., 1993; 17: 127-140.
  11. Olivier, G., Evelyn, T.P.T., Lallier, R.: Immunity to Aeromonas salmonicida in coho salmon (O. kisuttch) induced by modified freund’s complete adjuvant: Its non-specific nature and the probable role of macrophages in the phenomenon. Dev. Comp. Immunol.,1985; 9: 419-432.
  12. Kitao, F., Yoshida, Y., Anderson, D.P., Dixon, O.W., Blanch, A.: Immunostimulation of antibody – producing cells and humoral antibody to fish bacterins by a biological response modifier. J. Fish Biol., 1987; 31 (Supp. A): 87-91.
  13. Jeney, G., Anderson, D.P.: An in vitro technique for surveying immunostimulants in fish. Aquaculture, 1993; 112: 283-287.
  14. Symoens, J., Rosenthal, M.: Levamisole in the modulation of the immune response: the current experimental and clinical state. J. Reticuloendothel. Soc., 1977; 21: 175-221.
  15. Jeney, G., Galeotti, M, Volpatti, D.: Effects of immunostimulation on the n