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Dergiler / Turkish Journal of Veterinary and Animal Sciences / 2005 / Cilt: 29 - Sayı: 2

The Effects of Vitamin E and Selenium on Cypermethrin-Induced Oxidative Stress in Rats

Ahmet ATEŞŞAHİN
Sayfa
385–391
Yayın Tarihi
2005-02-01
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The results suggest that CYP can induce oxidative stress and VitE can modify CYP metabolism and play a protective role against CYP-induced oxidative stress.

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Amaç & Hipotez:The aim of this study was to investigate whether vitamin E (VitE) and selenium (Se) or VitE plus Se have any the protective and/or augmented effects on cypermethrin (CYP)-induced oxidative stress in liver, brain, kidney and blood in rats.
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Temel Bulgular & Veri:Rats were treated orally with daily 50 mg/kg (~ 1/4 ED50) of CYP in corn oil for five days after administrations of VitE (100 mg/kg sc.), Se (0.1 mg/kg, sc.) and VitE plus Se for three days.
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Sonuç & Katkı:The results suggest that CYP can induce oxidative stress and VitE can modify CYP metabolism and play a protective role against CYP-induced oxidative stress.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Catalase · cypermethrin · glutathione peroxidase

Özet

The aim of this study was to investigate whether vitamin E (VitE) and selenium (Se) or VitE plus Se have any the protective and/or augmented effects on cypermethrin (CYP)-induced oxidative stress in liver, brain, kidney and blood in rats. Rats were treated orally with daily 50 mg/kg (~ 1/4 ED50) of CYP in corn oil for five days after administrations of VitE (100 mg/kg sc.), Se (0.1 mg/kg, sc.) and VitE plus Se for three days. Malondialdehyde (MDA) concentrations, glutathione peroxidase (GSH-Px) and catalase (CAT) activities were measured in tissues and blood samples. MDA concentrations in all tissues except plasma, and GSH-Px activities in liver and erythrocytes were significantly increased, but CAT activities in all tissues except erythrocytes were decreased in CYP treated group when compared with the control group. Treatment with VitE prior to CYP reduced sensitivity on CYP-induced oxidative stress. The use of Se was observed to increase both MDA concentrations and antioxidant systems such as GSH-Px and CAT activities. On the other hand, VitE plus Se caused complex alterations in the antioxidant system on the oxidative stress induced by CYP. The results suggest that CYP can induce oxidative stress and VitE can modify CYP metabolism and play a protective role against CYP-induced oxidative stress.

Abstract

The aim of this study was to investigate whether vitamin E (VitE) and selenium (Se) or VitE plus Se have any the protective and/or augmented effects on cypermethrin (CYP)-induced oxidative stress in liver, brain, kidney and blood in rats. Rats were treated orally with daily 50 mg/kg (~ 1/4 ED50) of CYP in corn oil for five days after administrations of VitE (100 mg/kg sc.), Se (0.1 mg/kg, sc.) and VitE plus Se for three days. Malondialdehyde (MDA) concentrations, glutathione peroxidase (GSH-Px) and catalase (CAT) activities were measured in tissues and blood samples. MDA concentrations in all tissues except plasma, and GSH-Px activities in liver and erythrocytes were significantly increased, but CAT activities in all tissues except erythrocytes were decreased in CYP treated group when compared with the control group. Treatment with VitE prior to CYP reduced sensitivity on CYP-induced oxidative stress. The use of Se was observed to increase both MDA concentrations and antioxidant systems such as GSH-Px and CAT activities. On the other hand, VitE plus Se caused complex alterations in the antioxidant system on the oxidative stress induced by CYP. The results suggest that CYP can induce oxidative stress and VitE can modify CYP metabolism and play a protective role against CYP-induced oxidative stress.

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Bu Makaleye Atıf Yap

ATEŞŞAHİN, A. (2005). The Effects of Vitamin E and Selenium on Cypermethrin-Induced Oxidative Stress in Rats. Turkish Journal of Veterinary and Animal Sciences, Cilt: 29 - Sayı: 2, 385–391. https://ajindex.com/articles/122343

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Kaynakça (13)

  1. Anand, R.K., Kanwar, U.: Role of some trace metal ions in placental membrane lipid peroxidation. Biol. Trace Elem. Res., 2001; 82: 61-75.
  2. El-Demerdash, F.M.: Effects of selenium and mercury on the enzymatic activities and lipid peroxidation in brain, liver and blood of rats. J. Environ. Sci. Hlth. B., 2001; 36: 489-499.
  3. Akhtar, M.H., Mahadevan, S., Paquet, A.: Comparative metabolism of deltamethrin and 3 phenoxybenzoic acid in chickens. J. Environ. Sci. Hlth., 1994; 29: 369-394.
  4. Gupta, A., Nigam, D., Shukla, G.S., Agarwal, A.K.: Effect of pyrethroids based liquid mosquito repellent inhalation on the blood-brain barrier function and oxidative damage in selected organs of developing rats. J. Appl. Toxicol., 1999; 19: 67-72.
  5. Üner, N., Özcan Oruç, E., Canlı, M., Sevgiler. Y.: Effects of cypermethrin on antioxidant enzyme activities and lipid peroxidation in liver and kidney of the freshwater fish, Oreochromis niloticus and Cyprinus carpio (L.). Bull. Environ. Contam. Toxicol., 2001; 67: 657-664.
  6. Aldana, L., Tsutsumi, V., Craigmill, A., Silveria, M.I., Mejia, E.G.: Alpha-tocopherol modulates liver toxicity of pyrethroid cypermethrin. Toxicol. Lett., 2001; 125: 107-116.
  7. Tokuda, M., Takeuchi, M.: Effects of excess doses alpha- tocopherol on the lipids and function of rainbow trout liver. J. Nutr. Sci. Vitaminol., 1995; 41: 25-32.
  8. Vannucchi, H., Jordao Junior, A.A., Iglesias, A.C., Morandi, M.V., Chiarello, P.G.: Effect of different dietary concentrations of vitamin E on lipid peroxidation in rats. Arch. Latinoam. Nutr., 1997; 47: 34-37.
  9. Avanzo, J.L., De Mendonca, C.X. Jr, Pugine, S.M., De Cerqueira Cesar, M.: Effect of vitamin E and selenium on resistance to oxidative stress in chicken superficial pectoralis muscle. Comp. Biochem. Physiol. C Toxicol. Pharmacol., 2001; 129: 163-173.
  10. Giray, B., Gürbay, A., Hincal, F.: Cypermethrin-induced oxidative stress in rat brain and liver is prevented by vitamin E or allopurinol. Toxicol. Lett., 2001; 118: 139-146.
  11. Flannigan, S.A., Tucker, S.B., Key, M.M., Ross, C.E., Fairchild, E.J., Grimes, B.A., Harrist, R.B.: Synthetic pyrethroid insecticides: A dermatological evaluation. Br. J. Ind. Med., 1985; 42: 363- 372. Song, J.H., Narahashi, T.: Selective block of tetramethrin- modified sodium channels by (+/-)-alpha-tocopherol. J. Pharmacol. Exp. Ther., 1996; 277: 445-453.
  12. Combs, G.F., Combs, S.B.: The role of selenium in nutrition. London: Academic Press Inc, 1986.
  13. Ganther, H.E.: Pathways of selenium metabolism including respirat