Dergiler / KONURALP TIP DERGİSİ / 2026 / Volume: 18 Issue: 2

Effect of Particulate Matter and Greenhouse Gases on Immune System

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Yayın Tarihi
2026-06-26
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

This review aims to promote the development of effective treatment strategies by examining the relationship between air pollutants and the immune system.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Air pollutants cause 7 million deaths and disabilities worldwide each year.
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Temel Bulgular & Veri:Particulate matter and greenhouse gases (CO, O3, SO2, volatile organic compounds, NOx) which enter the body especially through inhalation, stimulate the immune system by causing damage to the respiratory tract mucosal defense barrier.
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Sonuç & Katkı:This review aims to promote the development of effective treatment strategies by examining the relationship between air pollutants and the immune system.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Particulate matter · greenhouse gases · immune system

Abstract

Air pollutants cause 7 million deaths and disabilities worldwide each year. Mostly, the negative effects of air pollution on health occur by disrupting the functioning of immune system cells. Particulate matter and greenhouse gases (CO, O3, SO2, volatile organic compounds, NOx) which enter the body especially through inhalation, stimulate the immune system by causing damage to the respiratory tract mucosal defense barrier. Subsequently, the innate and/or adaptive immune system responds to the foreign agent that causes the disease through macrophages, dendritic cells, lymphocytes and granulocytes. Increased infiltration of immune system cells into the tissue, cytokine release, inflammation and oxidative stress cause many chronic diseases, especially immune system functioning, respiratory, cardiovascular and neurological diseases. Considering the negative effects of air pollutants on body health through the immune system, it can be said that developing new treatment strategies centered on the immune system to minimize these negative effects may offer a more effective option. This review aims to promote the development of effective treatment strategies by examining the relationship between air pollutants and the immune system.

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Bu Makaleye Atıf Yap

Damar, İ. H. (2026). Effect of Particulate Matter and Greenhouse Gases on Immune System. KONURALP TIP DERGİSİ, Volume: 18 Issue: 2. https://doi.org/10.18521/ktd.1583380

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Kaynakça (53)

  1. Xie J, Wang M, Long Z, Ning H, Li J, Cao Y, et al. Global burden of type 2 diabetes in adolescents and young adults, 1990-2019: systematic analysis of the Global Burden of Disease Study 2019. BMJ. 2022;379:e072385. doi:10.1136/bmj-2022-072385.
  2. Rajagopalan S, Landrigan PJ. Pollution and the heart. N Engl J Med. 2021;385(20):1881-92. doi:10.1056/NEJMra2030281.
  3. Urrutia-Pereira M, Guidos-Fogelbach G, Solé D. Climate changes, air pollution and allergic diseases in childhood and adolescence. J Pediatr (Rio J). 2022;98(Suppl 1):S47-54. doi:10.1016/j.jped.2021.10.005.
  4. Glencross DA, Ho TR, Camiña N, Hawrylowicz CM, Pfeffer PE. Air pollution and its effects on the immune system. Free Radic Biol Med. 2020;151:56-68. doi:10.1016/j.freeradbiomed.2020.01.179.
  5. Tripathy S, Marsland AL, Kinnee EJ, Tunno BJ, Manuck SB, Gianaros PJ, et al. Long-term ambient air pollution exposures and circulating and stimulated inflammatory mediators in a cohort of midlife adults. Environ Health Perspect. 2021;129(5):57007. doi:10.1289/EHP7089.
  6. Rao X, Zhong J, Brook RD, Rajagopalan S. Effect of particulate matter air pollution on cardiovascular oxidative stress pathways. Antioxid Redox Signal. 2018;28(9):797-818. doi:10.1089/ars.2017.7394.
  7. Yao Y, Wang D, Ma H, Li C, Chang X, Low P, et al. The impact on T-regulatory cell related immune responses in rural women exposed to polycyclic aromatic hydrocarbons (PAHs) in household air pollution in Gansu, China: a pilot investigation. Environ Res. 2019;173:306-17. doi:10.1016/j.envres.2019.03.053.
  8. Damar İH, Eröz R. May argyrophilic nucleolar organizer regions be the new marker of a hypoxic response in non ST Elevation Myocardial Infarction? Konuralp Med J. 2022;14(1):132-41. doi:10.18521/ktd.1073568.
  9. Damar İH, Eroz R. Argyrophilic nucleolar organizer regions as new biomarkers in ST-Elevation Myocardial Infarction. J Cardiovasc Dev Dis. 2022;9(2):58. doi:10.3390/jcdd9020058.
  10. Damar İH, Eroz R. The role of macrophage in atherosclerosis: an overview. J Clin Pract Res. 2021;43(1):9-12. doi:10.14744/etd.2020.53077.
  11. Tiotiu AI, Novakova P, Nedeva D, Chong-Neto HJ, Novakova S, Steiropoulos P, et al. Impact of air pollution on asthma outcomes. Int J Environ Res Public Health. 2020;17(17):6212. doi:10.3390/ijerph17176212.
  12. Yang L, Li C, Tang X. The impact of PM2.5 on the host defense of respiratory system. Front Cell Dev Biol. 2020;8:91. doi:10.3389/fcell.2020.00091.
  13. Ma J, Chiu YF, Kao CC, Chuang CN, Chen CY, Lai CH, et al. Fine particulate matter manipulates immune response to exacerbate microbial pathogenesis in the respiratory tract. Eur Respir Rev. 2024;33(173):230259. doi:10.1183/16000617.0259-2023.
  14. Losacco C, Perillo A. Particulate matter air pollution and respiratory impact on humans and animals. Environ Sci Pollut Res Int. 2018;25(34):33901-10. doi:10.1007/s11356-018-3344-9.
  15. Dai MY, Chen FF, Wang Y, Wang MZ, Lv YX, Liu RY. Particulate matters induce acute exacerbation of allergic airway inflammation via the TLR2/NF-κB/NLRP3 signaling pathway. Toxicol Lett. 2020;321:146-54. doi:10.1016/j.toxlet.2019.12.013.
  16. Jia H, Liu Y, Guo D, He W, Zhao L, Xia S. PM2.5-induced pulmonary inflammation via activating of the NLRP3/caspase-1 signaling pathway. Environ Toxicol. 2021;36(3):298-307. doi:10.1002/tox.23035.
  17. Celebi Sozener Z, Özbey Yücel Ü, Altiner S, Ozdel Oztürk B, Cerci P, Türk M, et al. The external exposome and allergies: from the perspective of the epithelial barrier hypothesis. Front Allergy. 2022;3:887672. doi:10.3389/falgy.2022.887672.
  18. Park SK, Yeon SH, Choi MR, Choi SH, Lee SB, Rha KS, et al. Urban particulate matters may affect endoplasmic reticulum stress and tight junction disruption in nasal epithelial cells. Am J Rhinol Allergy. 2021;35(6):817-29. doi:10.1177/19458924211004006.
  19. Goossens J, Jonckheere AC, Dupont LJ, Bullens DMA. Air pollution and the airways: lessons from a century of human urbanization. Atmosphere. 2021;12(7):898. doi:10.3390/atmos12070898.
  20. Li T, Yu Y, Sun Z, Duan J. A comprehensive understanding of ambient particulate matter and its components on the adverse health effects based from epidemiological and laboratory evidence. Part Fibre Toxicol. 2022;19(1):67. doi:10.1186/s12989-022-00507-5.
  21. Hamilton RF Jr, Holian A, Morandi MT. A comparison of asbestos and urban particulate matter in the in vitro modification of human alveolar macrophage antigen-presenting cell function. Exp Lung Res. 2004;30(2):147-62. doi: 10.1080/01902140490266439.
  22. Kang CM, Jang AS, Ahn MH, Shin JA, Kim JH, Choi YS, et al. Interleukin-25 and interleukin-13 production by alveolar macrophages in response to particles. Am J Respir Cell Mol Biol. 2005;33(3):290-6. doi:10.1165/rcmb.2005-0003OC.
  23. Gour N, Wills-Karp M. IL-4 and IL-13 signaling in allergic airway disease. Cytokine. 2015;75(1):68-78. doi:10.1016/j.cyto.2015.05.014.
  24. Sokolowska M, Quesniaux VFJ, Akdis CA, Chung KF, Ryffel B, Togbe D. Acute respiratory barrier disruption by ozone exposure in mice. Front Immunol. 2019;10:2169. doi:10.3389/fimmu.2019.02169.
  25. Michaudel C, Fauconnier L, Julé Y, Ryffel B. Functional and morphological differences of the lung upon acute and chronic ozone exposure in mice. Sci Rep. 2018;8(1):10611. doi:10.1038/s41598-018-28261-9.
  26. Liu Y, Pan J, Zhang H, Shi C, Li G, Peng Z, et al. Short-term exposure to ambient air pollution and asthma mortality. Am J Respir Crit Care Med. 2019;200(1):24-32. doi:10.1164/rccm.201810-1823OC.
  27. Xu M, Wang L, Wang M, Wang H, Zhang H, Chen Y, et al. Mitochondrial ROS and NLRP3 inflammasome in acute ozone-induced murine model of airway inflammation and bronchial hyperresponsiveness. Free Radic Res. 2019;53(7):780-90. doi:10.1080/10715762.2019.1630735.
  28. Liao D, Heiss G, Chinchilli VM, Duan Y, Folsom AR, Lin HM, et al. Association of criteria pollutants with plasma hemostatic/inflammatory markers: a population-based study. J Expo Anal Environ Epidemiol. 2005;15(4):319-28. doi:10.1038/sj.jea.7500408.
  29. Chuang KJ, Chan CC, Su TC, Lee CT, Tang CS. The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults. Am J Respir Crit Care Med. 2007;176(4):370-6. doi:10.1164/rccm.200611-1627OC.
  30. Xia Y, Niu Y, Cai J, Lin Z, Liu C, Li H, et al. Effects of personal short-term exposure to ambient ozone on blood pressure and vascular endothelial function: a mechanistic study based on dna methylation and metabolomics. Environ Sci Technol. 2018;52(21):12774-82. doi:10.1021/acs.est.8b03044.
  31. Zhao N, Pinault L, Toyib O, Vanos J, Tjepkema M, Cakmak S. Long-term ozone exposure and mortality from neurological diseases in Canada. Environ Int. 2021;157:106817. doi:10.1016/j.envint.2021.106817.
  32. Ogbodo JO, Arazu AV, Iguh TC, Onwodi NJ, Ezike TC. Volatile organic compounds: A proinflammatory activator in autoimmune diseases. Front Immunol. 2022;13:928379. doi:10.3389/fimmu.2022.928379.
  33. Lehmann I, Rehwagen M, Diez U, Seiffart A, Rolle-Kampczyk U, Richter M, et al. Enhanced in vivo IgE production and T cell polarization toward the type 2 phenotype in association with indoor exposure to VOC: results of the LARS study. Int J Hyg Environ Health. 2001;204(4):211-21. doi:10.1078/1438-4639-00100.
  34. Hosgood HD 3rd, Zhang L, Tang X, Vermeulen R, Hao Z, Shen M, et al. Occupational exposure to formaldehyde and alterations in lymphocyte subsets. Am J Ind Med. 2013;56(2):252-7. doi:10.1002/ajim.22088.
  35. Sarma SN, Han T, Ryu JC, Kim YJ. Genome-wide analysis of dichloromethane-regulated genes in human promyelocytic leukemia HL-60 cells. BioChip J. 2012;6:65-72. doi:10.1007/s13206-012-6109-4.
  36. Pasala S, Barr T, Messaoudi I. Impact of alcohol abuse on the adaptive immune system. Alcohol Res. 2015;37(2):185-97. doi:10.35946/arcr.v37.2.04.
  37. Ruiz-Hernandez A, Kuo CC, Rentero-Garrido P, Tang WY, Redon J, Ordovas JM, et al. Environmental chemicals and DNA methylation in adults: a systematic review of the epidemiologic evidence. Clin Epigenetics. 2015;7(1):55. doi:10.1186/s13148-015-0055-7.
  38. Alford KL, Kumar N. Pulmonary health effects of indoor volatile organic compounds-a meta-analysis. Int J Environ Res Public Health. 2021;18(4):1578. doi:10.3390/ijerph18041578.
  39. Genc S, Zadeoglulari Z, Fuss SH, Genc K. The adverse effects of air pollution on the nervous system. J Toxicol. 2012;2012:782462. doi:10.1155/2012/782462.
  40. Cakmak S, Cole C, Hebbern C, Andrade J, Dales R. Associations between blood volatile organic compounds, and changes in hematologic and biochemical profiles, in a population-based study. Environ Int. 2020;145:106121. doi:10.1016/j.envint.2020.106121.
  41. Liu H, Tian Y, Xiang X, Li M, Wu Y, Cao Y, et al. Association of short-term exposure to ambient carbon monoxide with hospital admissions in China. Sci Rep. 2018;8(1):13336. doi:10.1038/s41598-018-31434-1.
  42. She X, Gao X, Wang K, Yang H, Ma K, Cui B, et al. Effects of noise and low-concentration carbon monoxide exposure on rat immunity. J Occup Health. 2021;63(1):e12235. doi:10.1002/1348-9585.12235.
  43. Giustino A, Carratu MR, Siro Brigiani G, De Salvia MA, Pellegrino NM, Steardo L, et al. Changes in the frequency of splenic immunocompetent cells in rats exposed to carbon monoxide during gestation. Immunopharmacol Immunotoxicol. 1994;16(2):281-92. doi:10.3109/08923979409007095.
  44. Giustino A, Carratu MR, Siro Brigiani G, de Salvia MA, Pellegrino NM, Steardo L, et al. Changes in the frequency of splenic immunocompetent cells in rats exposed to carbon monoxide during gestation. Immunopharmacol Immunotoxicol. 1994;16(2):281-92. doi:10.3109/08923979409007095.
  45. Gao X, Colicino E, Shen J, Kioumourtzoglou MA, Just AC, Nwanaji-Enwerem JC, et al. Impacts of air pollution, temperature, and relative humidity on leukocyte distribution: an epigenetic perspective. Environ Int. 2019;126:395-405. doi:10.1016/j.envint.2019.02.053.
  46. Temrel TA, Bilge S. Myocardial repolarization parameters and neutrophil-to-lymphocyte ratio are associated with cardiotoxicity in carbon monoxide poisoning. Cardiovasc Toxicol. 2020 Apr;20(2):190-196. doi:10.1007/s12012-019-09560-7.
  47. Chatkin J, Correa L, Santos U. External environmental pollution as a risk factor for asthma. Clin Rev Allergy Immunol. 2022;62(1):72-89. doi:10.1007/s12016-020-08830-5.
  48. Devalia JL, Campbell AM, Sapsford RJ, Rusznak C, Quint D, Godard P, et al. Effect of nitrogen dioxide on synthesis of inflammatory cytokines expressed by human bronchial epithelial cells in vitro. Am J Respir Cell Mol Biol. 1993;9(3):271-8. doi:10.1165/ajrcmb/9.3.271.
  49. Pathmanathan S, Krishna MT, Blomberg A, Helleday R, Kelly FJ, Sandström T, et al. Repeated daily exposure to 2 ppm nitrogen dioxide upregulates the expression of IL-5, IL-10, IL-13, and ICAM-1 in the bronchial epithelium of healthy human airways. Occup Environ Med. 2003;60(11):892-6. doi:10.1136/oem.60.11.892.
  50. Feng Z, Xu L, Xie Z. receptors for respiratory syncytial virus infection and host factors regulating the life cycle of respiratory syncytial virus. Front Cell Infect Microbiol. 2022;12:858629. doi:10.3389/fcimb.2022.858629.
  51. Yang BY, Fan S, Thiering E, Seissler J, Nowak D, Dong GH, et al. Ambient air pollution and diabetes: a systematic review and meta-analysis. Environ Res. 2020;180:108817. doi:10.1016/j.envres.2019.108817.
  52. Wolf K, Hoffmann B, Andersen ZJ, Atkinson RW, Bauwelinck M, Bellander T, et al. Long-term exposure to low-level ambient air pollution and incidence of stroke and coronary heart disease: a pooled analysis of six European cohorts within the ELAPSE project. Lancet Planet Health. 2021;5(9):e620-32. doi:10.1016/S2542-5196(21)00195-9.
  53. Niu Z, Liu F, Yu H, Wu S, Xiang H. Association between exposure to ambient air pollution and hospital admission, incidence, and mortality of stroke: an updated systematic review and meta-analysis of more than 23 million participants. Environ Health Prev Med. 2021;26(1):15. doi:10.1186/s12199-021-00937-1.