Dergiler / Kocatepe Tıp Dergisi / 2026 / Cilt: 21 Sayı: 2

KRONİK BOYUN AĞRISI ŞİKAYETİ OLAN HASTALARDA SERUM D VİTAMİNİ SEVİYELERİ, AĞRI ŞİDDETİ VE SERVİKAL DİSK DEJENERASYONU İLİŞKİLİ MİDİR?

CERVICAL DISC DEGENERATION, SEVERITY OF PAIN AND VITAMIN D LEVELS IN PATIENTS WITH CHRONIC NECK PAIN: IS THERE ANY RELATIONSHIP?

Sayfa
195–200
Yayın Tarihi
2020-05-11
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BULGULAR: Çalışmaya 123 hasta dahil edildi.

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Amaç & Hipotez:AMAÇ: Kemik metabolizması üzerinde D vitaminin etkileri uzun zamandır bilinmektedir.
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Temel Bulgular & Veri:GEREÇ VE YÖNTEM: Beyin cerrahisi polikliniğine kronik boyun ağrısı şikayeti ile başvuran hastaların serum D vitamini seviyeleri, başvuru sırasındaki ağrı şiddeti (VAS) değerleri ve servikal MRG incelemeleri retrospektif olarak değerlendirildi.
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Sonuç & Katkı:BULGULAR: Çalışmaya 123 hasta dahil edildi.
🔬Tür:Deneysel Tarla Denemesi
📍Kapsam:123 hasta
⚙️Değişkenler:Vitamin D · neck pain · Magnetic resonance imaging

Özet

AMAÇ: Kemik metabolizması üzerinde D vitaminin etkileri uzun zamandır bilinmektedir. Çalışmamızda serum vitamin D seviyeleri ile intervertebral disk dejenerasyonu, disk yüksekliği ve ağrı şiddeti arasındaki ilişkiyi saptamayı hedefledik. GEREÇ VE YÖNTEM: Beyin cerrahisi polikliniğine kronik boyun ağrısı şikayeti ile başvuran hastaların serum D vitamini seviyeleri, başvuru sırasındaki ağrı şiddeti (VAS) değerleri ve servikal MRG incelemeleri retrospektif olarak değerlendirildi. BULGULAR: Çalışmaya 123 hasta dahil edildi. Vitamin D düzeylerine göre ayrılan gruplar arasında, VAS skorlarına göre anlamlı fark saptanmıştır (p=0.003). Vitamin D düzeylerine göre ayrılan gruplar arasında yapılan karşılaştırmalarda yaş (p=0.180), cinsiyet (p=0. 244/p=0.146) ve servikal C5-6 disk yüksekliği açısından (p= 0.299) istatistiksel olarak anlamlı bir ilişki bulunamamıştır. SONUÇ: Çalışmamızda, servikal disk dejenerasyonu ve servikal lordoz kaybı olan hastalarda düşük serum vitamin D seviyeleri ile VAS arasında anlamlı fark saptanmıştır. Metabolik düzeyde D vitamini eksikliğinin, kronik boyun ağrısı ile başvuran, muayenede nörolojik bozukluğu ve disk hernisi olmayan hastalarda göz önünde bulundurulması gerektiğine inanıyoruz.

Abstract

OBJECTIVE: Effects of vitamin D on bone metabolism has been long known. We aimed to detect the relationship between vitamin D levels and intervertebral disc degeneration, disc height and severity of pain in patients with chronic neck pain. MATERIAL AND METHODS: The data of patients who were admitted to neurosurgery polyclinic with chronic neck pain complaints were analyzed retrospectively, whom their vitamin D levels measured, pain severity (VAS) scores ware noted at the time of admission and were radiologically examined with cervical MRI. RESULTS: Overall, 123 patients were included in the study. There was a significant relationship in terms of VAS scores between the groups divided on the basis of vitamin D levels (p=0.003). There was no statistically significant relationship in terms of age (p=0.180), gender (p=0. 244/p=0.146), and cervical C5-6 disk height (p= 0.299) in the comparison performed within the groups divided on the basis of vitamin D levels. CONCLUSIONS: In the present study, it was shown that there is a significant relationship between low vitamin D levels and VAS in patients who had cervical disk degeneration and loss of cervical lordosis. We believe that vitamin D deficiency at a metabolic level should be considered in patients who are admitted with chronic neck pain, who do not exhibit neurologic deficits in the examination, and who do not have disc hernia.

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Bu Makaleye Atıf Yap

Altaş, H., Yılmaz, A. (2020). KRONİK BOYUN AĞRISI ŞİKAYETİ OLAN HASTALARDA SERUM D VİTAMİNİ SEVİYELERİ, AĞRI ŞİDDETİ VE SERVİKAL DİSK DEJENERASYONU İLİŞKİLİ MİDİR?. Kocatepe Tıp Dergisi, Cilt: 21 Sayı: 2, 195–200. https://doi.org/10.18229/kocatepetip.634480

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Kaynakça (22)

  1. Bikle DD: Vitamin D and immune function: understanding common pathways. Current osteoporosis reports. 2009;7(2):58-63. 2.Zehnder D, Bland R, Williams MC,et al. Extrarenal expression of 25-hydroxyvitamin D3-1α-hydroxylase. The Journal of ClinicalEndocrinology&Metabolism. 2001;86 (2):888-894.
  2. Tuffaha M, El Bcheraoui C, Daoud F,et al. Deficiencies under plenty of sun: Vitamin D status among adults in the kingdom of Saudi Arabia, 2013. North American journal of medical sciences. 2015;7(10 ):467-75.
  3. Heidari B, Shirvani JS, Firouzjahi A, et al. Association between nonspecific skeletal pain and vitamin D deficiency. International journal of rheumatic diseases. 2010;13(3):340-346.
  4. Pfeifer M, Begerow B, Minne H. Vitamin D and muscle function. Osteoporosis International. 2002; 13(3):187-194.
  5. Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo clinic proceedings. 2003; 78 (12):1463-70.
  6. Lane NE, Gore LR, Cummings SR,et al. Serum vitamin D levels and incident changes of radiographic hip osteoarthritis: a longitudinal study. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology. 1999; 42 (5):854-860.
  7. Royce PM, Steinmann B. Connective tissue and its heritable disorders: molecular, genetic, and medical aspects. John Wiley & Sons. 2003 159-162.
  8. Bunout D, Barrera G, Leiva L,et al. Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects. Experimental gerontology. 2006; 41 (8):746-752.
  9. Singh S, Cuzick J, Mesher D, et al. Effect of baseline serum vitamin D levels on aromatase inhibitors induced musculoskeletal symptoms: results from the IBIS-II, chemoprevention study using anastrozole. Breast cancer research and treatment. 2012; 132 (2):625-629. 11.Straube S, Moore AR, Derry S, et al.Vitamin D and chronic pain. Pain. 2009;1 (41):10-13.
  10. Tetlow LC, Smith SJ, Mawer EB, et al. Vitamin D receptors in the rheumatoid lesion: expression by chondrocytes, macrophages, and synoviocytes. Annals of the rheumatic diseases. 1999; 58 (2):118-121.
  11. Turner MK, Hooten WM, Schmidt JE, et al. Prevalence and clinical correlates of vitamin D inadequacy among patients with chronic pain. Pain Medicine. 2008; 9(8):979-984.
  12. Knutsen KV, Madar AA, Brekke M,et al. Effect of vitamin D on musculoskeletal pain and headache A randomized, double-blind, placebo-controlled trial among adult ethnic minorities in Norway.Pain. 2014; 155 (12):2591-2598.
  13. Lodh M, Goswami B, Mahajan RD, et al. Assessment of vitamin D status in patients of chronic low back pain of unknown etiology. Indian Journal of Clinical Biochemistry. 2015; 30(2):174-179.
  14. Glover T, Goodin B, Horgas A, et al. Vitamin D, race, and experimental pain sensitivity in older adults with knee osteoarthritis. Arthritis & Rheumatism. 2012;64(12):3926-3935.
  15. Gruber HE, Hoelscher G, Ingram JA, et al. 1, 25 (OH) 2-vitamin D3 inhibits proliferation and decreases production of monocyte chemoattractant protein-1, thrombopoietin, VEGF, and angiogenin by human annulus cellsinvitro. Spine. 2008;33(7):755-765.
  16. Werina K, Baum W, Axmann R, et al. Vitamin D receptor regulates TNF-mediated arthritis. Annals of the rheumatic diseases:annrheumdis.2011;14(6):23-31.
  17. Stoffels K, Overbergh L, Giulietti A, et al. Immune regulation of 25 hydroxyvitamin D3 1α hydroxylase in human monocytes. Journal of Bone and Mineral Research. 2006; 21(1):37-47.
  18. Stoker GE, Buchowski JM, Bridwell KH, et al. Preoperative vitamin D status of adults undergoing surgical spinal fusion. Global Spine journal. 2013; 38(6):507-515.
  19. Grob D, Frauenfelder H, Mannion A. The association between cervical spine curvature and neck pain. European Spine Journal. 2007; 16(5):669-678.
  20. Wynne-Davies R, Walsh W, GormleyJ. Achondroplasia and hypochondroplasia. Clinical variation and spinal stenosis. The Journal of bone and joint surgery. 1981; 63(4):508-515.
  21. Bikle DD: Vitamin D and immune function: understanding common pathways. Current osteoporosis reports. 2009;7(2):58-63. 2.Zehnder D, Bland R, Williams MC,et al. Extrarenal expression of 25-hydroxyvitamin D3-1α-hydroxylase. The Journal of ClinicalEndocrinology&Metabolism. 2001;86 (2):888-894.
  22. Bunout D, Barrera G, Leiva L,et al. Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects. Experimental gerontology. 2006; 41 (8):746-752.