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Dergiler / Kocatepe Tıp Dergisi / 2026 / Cilt: 25 Sayı: 2

TİP 2 DİABETES MELLİTUSLU HASTALARDA LİNAGLİPTİN'İN ARİTMİ ÜZERİNE ETKİSİ

THE EFFECT OF LINAGLIPTIN ON ARRHYTHMIA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Oğuz Kaan Kaya(S.B.Ü. ANTALYA EĞİTİM VE ARAŞTIRMA HASTANESİ)0000-0002-0267-5912
Gökhan Köker(SBÜ Antalya Eğitim ve Araştırma Hastanesi)0000-0003-1745-8002
Sayfa
201–207
Yayın Tarihi
2024-04-29
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

P dalga dispersiyonu ve QT dispersiyonu, atriyal fibrilasyon ve ventriküler taşiaritmilerle ilişkili elektrokardiyografik bulgulardır.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:AMAÇ: Linagliptin, inkretin hormonlarının inaktivasyonunu engelleyen ve ayrıca glukoza bağımlı insülin salınımını uyaran bir dipeptidil peptidaz-4 (DPP-4) inhibitörüdür.
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Temel Bulgular & Veri:Bu çalışmadaki amacımız, Tip 2 diabetes mellituslu (Tip 2 DM) hastalarda linagliptin uygulamasının P dalga dispersiyonu ve QT dispersiyonu üzerine bir etkisinin olup olmadığını araştırmaktır.
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Sonuç & Katkı:P dalga dispersiyonu ve QT dispersiyonu, atriyal fibrilasyon ve ventriküler taşiaritmilerle ilişkili elektrokardiyografik bulgulardır.
🔬Tür:Deneysel Tarla Denemesi
📍Kapsam:2019 Verileri
⚙️Değişkenler:Dipeptidil peptidaz-4 (DPP-4) inhibitörü · Tip 2 diabetes mellitus · P dalga dispersiyonu

Özet

AMAÇ: Linagliptin, inkretin hormonlarının inaktivasyonunu engelleyen ve ayrıca glukoza bağımlı insülin salınımını uyaran bir dipeptidil peptidaz-4 (DPP-4) inhibitörüdür. P dalga dispersiyonu ve QT dispersiyonu, atriyal fibrilasyon ve ventriküler taşiaritmilerle ilişkili elektrokardiyografik bulgulardır. Bu çalışmadaki amacımız, Tip 2 diabetes mellituslu (Tip 2 DM) hastalarda linagliptin uygulamasının P dalga dispersiyonu ve QT dispersiyonu üzerine bir etkisinin olup olmadığını araştırmaktır. GEREÇ VE YÖNTEM: Çalışmaya Ekim 2019 - Mayıs 2021 tarihleri arasında Eğitim ve Araştırma Hastanesi dahiliye polikliniğine başvuran ve linagliptin başlanan 60 rastgele hasta (28 kadın- %46,7, 18 hipertansiyon- %30, 16 sigara içen- %26,7) dahil edildi. Hastaların 6. ayın başında ve sonunda elektrokardiyogramları çekildi. Hastaların linagliptin başlandığı anda ve 6. ayda ekokardiyografileri yapıldı. BULGULAR: Bazal ve 6. ay elektrokardiyogramları karşılaştırıldığında, P dalga dispersiyonu (0.0435 ± 0.014 - 0.0312 ± 0.011 p<0.01), QT dispersiyonu (0.0496 ± 0.01 - 0.0402 ± 0.01 p<0.01) ve QTc dispersiyonunda ( 0.051 ± 0.01 - 0.038 ± 0.14 p<0.01) anlamlı değişiklikler olduğunu saptadık. SONUÇ: Bu çalışmada linagliptinin aritmi üzerine olumsuz bir etkisinin olmadığını gösterdik. Çalışmamız daha uzun soluklu çalışmalar için yol gösterici olacaktır.

Abstract

OBJECTIVE: Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that prevents the inactivation of incretin hormones and also stimulates the release of glucose-dependent insulin. Electrocardiographic abnormalities such as P wave dispersion and QT dispersion are associated with ventricular tachyarrhythmias and atrial fibrillation, respectively. In this study, we seek to determine if the introduction of linagliptin has any impact on the P wave dispersion and QT dispersion in individuals with Type 2 diabetes mellitus (Type 2 DM). MATERIAL AND METHODS: The study included 60 random patients (28 females- 46.7 % , 18 hypertension- 30 %, 16 smokers- 26.7 % ) who were admitted to the Training and Research Hospital internal medicine policlinic between October 2019 and May 2021 and who started linagliptin. The patients' electrocardiograms were taken at the start and the conclusion of the sixth month. Echocardiography was performed at treatment initiation and at the 6th month. RESULTS: When basal and 6th month electrocardiograms were compared, significant changes were observed in P wave dispersion (0.0435 ± 0.014 - 0.0312 ± 0.011 p<0.01), QT interval dispersion (0.0496 ± 0.01 - 0.0402 ± 0.01 p<0.01) and QTc interval dispersion (0.051 ± 0.01 - 0.038 ± 0.14 p<0.01). CONCLUSIONS: We demonstrated in this study that linagliptin had no detrimental effects on heart rhythm. Our study will be a guide for longer follow-up studies.

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Bu Makaleye Atıf Yap

Kaya, O. K., Köker, G. (2024). TİP 2 DİABETES MELLİTUSLU HASTALARDA LİNAGLİPTİN'İN ARİTMİ ÜZERİNE ETKİSİ. Kocatepe Tıp Dergisi, Cilt: 25 Sayı: 2, 201–207. https://doi.org/10.18229/kocatepetip.1195333

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