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Dergiler / Kırıkkale Üniversitesi Tıp Fakültesi Dergisi / 2026 / Cilt: 27 Sayı: 2

Sistemik Lupus Eritematozus’lu Hastalarda C-Reaktif Proteindeki Tek Nükleotid Polimorfizmlerin Araştırılması

INVESTIGATION OF SINGLE NUCLEOTIDE POLYMORPHISMS IN C-REACTIVE PROTEIN IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Gül Sandal Uzun(CUKUROVA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, RHEUMATOLOGY)0000-0002-5010-9114
Suzan Dinkçi(CUKUROVA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, RHEUMATOLOGY)0000-0002-8044-6031
Esra Kayacan Erdoğan(CUKUROVA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, RHEUMATOLOGY)0000-0002-3570-875X
Özcan Uzun(CUKUROVA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF ACADEMIC EMERGENCY MEDICINE)0009-0001-6507-724X
Eren Erken(CUKUROVA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, RHEUMATOLOGY)0000-0001-6902-624X
Sayfa
163–168
Yayın Tarihi
2025-08-25
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bulgular: Bu çalışmaya 74 SLE hastası ve 72 sağlıklı kontrol dahil edildi.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amaç: Bu çalışmada, sistemik lupus eritematozus (SLE) hastalarında C-reaktif protein (CRP) gen polimorfizmlerinin sıklığı ve bu polimorfizmlerin hastalığın klinik ve laboratuvar özellikleriyle ilişkisi araştırıldı.
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Temel Bulgular & Veri:CRP genindeki tek nükleotid polimorfizmleri (rs1130864, rs1205 ve rs1800947) her iki grupta da genotiplendirildi.
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Sonuç & Katkı:Bulgular: Bu çalışmaya 74 SLE hastası ve 72 sağlıklı kontrol dahil edildi.
🔬Tür:Laboratuvar & Saha Deneyi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Sistemik lupus eritematozus · c-reaktif protein · biomarker

Özet

Amaç: Bu çalışmada, sistemik lupus eritematozus (SLE) hastalarında C-reaktif protein (CRP) gen polimorfizmlerinin sıklığı ve bu polimorfizmlerin hastalığın klinik ve laboratuvar özellikleriyle ilişkisi araştırıldı. Gereç ve Yöntemler: Üçüncü basamak hastanede romatoloji bölümüne başvuran SLE hastaları çalışmaya dahil edildi. Romatolojik ve sistemik hastalık öyküsü olmayan yaş-cinsiyet eşleştirilmiş sağlıklı bireyler kontrol grubu olarak seçildi. CRP genindeki tek nükleotid polimorfizmleri (rs1130864, rs1205 ve rs1800947) her iki grupta da genotiplendirildi. Rs1205 (CC/CT/TT), rs1130864 (CC/CT/TT) ve rs1800947 (CC/GC) için genotip sıklıkları hastalar ve kontrol grupları arasında karşılaştırıldı. SLE hastalarında polimorfizmlerin varlığı ve hastalığın klinik belirtileri arasındaki ilişki incelendi. Bulgular: Bu çalışmaya 74 SLE hastası ve 72 sağlıklı kontrol dahil edildi. SLE grubunda genotip sıklıkları şu şekildeydi: Rs1205: CC, % 43,7 (n=31); CT, % 46,5 (n=33); ve TT, % 9,9 (n=7); rs1130864: CC, % 54,3 (n=38); CT, % 42,9 (n=30); ve TT, % 2,9 (n=2); rs1800947: GC, % 93,1 (n=67). SLE hastaları ve kontroller arasında CRP genindeki tek nükleotid polimorfizmleri sıklıklarında istatistiksel olarak anlamlı bir fark gözlenmedi. Rs1205 CC genotipi, SLE hastalarında daha yüksek oral ülser sıklığı ve daha düşük kompleman seviyeleri ile ilişkilendirildi. Sonuç: CRP geni tek nükleotid polimorfizmleri ile SLE yatkınlığı arasında bir ilişki saptanmamış olsa da, bu polimorfizmler SLE hastalarının belirli klinik özelliklerini etkileyebilir.

Abstract

Objective: This study investigated the frequency of C-reactive protein (CRP) gene polymorphisms and their association with clinical and laboratory features in systemic lupus erythematosus (SLE). Material and Methods: A cohort of SLE patients presenting to the tertiary rheumatology department center was enrolled. Agesex matched healthy individuals without a history of rheumatologic/systemic disease served as controls. Single nucleotide polymorphisms (SNPs) within the CRP gene (rs1130864, rs1205, and rs1800947) were genotyped in both groups. The genotype frequencies for rs1205 (CC/CT/TT), rs1130864 (CC/CT/TT), and rs1800947 (CC/GC) were compared between SLE patients and controls. Associations between SNPs and clinical manifestations of SLE patients were assessed. Results: This study included 74 SLE patients and 72 healthy controls. In the SLE group, genotype frequencies were as follows: Rs1205: CC, 43.7 % (n=31); CT, 46.5 % (n=33); and TT, 9.9 % (n=7); rs1130864: CC, 54.3 % (n=38); CT, 42.9 % (n=30); and TT, 2.9 % (n=2); rs1800947: GC, 93.1 % (n=67). No statistically significant differences in SNP frequencies were observed between SLE patients and controls. The rs1205 CC genotype was associated with higher prevalence of oral ulcers and lower complement levels in SLE patients. Conclusion: While no association with disease susceptibility was identified, CRP gene polymorphisms may influence specific clinical features of SLE patients.

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Bu Makaleye Atıf Yap

Uzun, G. S., Dinkçi, S., Erdoğan, E. K., Uzun, Ö., Erken, E. (2025). Sistemik Lupus Eritematozus’lu Hastalarda C-Reaktif Proteindeki Tek Nükleotid Polimorfizmlerin Araştırılması. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, Cilt: 27 Sayı: 2, 163–168. https://doi.org/10.24938/kutfd.1665634

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