KaydedilenlerDerginizi ekleyin

Dergiler / Turkish Journal of Veterinary and Animal Sciences / 2015 / Cilt: 39 - Sayı: 2

Influences of flunixin and tenoxicam on the pharmacokinetics of florfenicol in lipopolysaccharide-induced endotoxemia

Feride KOÇ
Alptuğ ATİLA
Emre KARAKUŞ
Kamil ÜNEY
Sayfa
168–173
Yayın Tarihi
2015-08-13
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

When FF is coadministered with FM and TN, it can be given at a dose of 20 mg/kg b.w. every 8 h for treatment of infections caused by susceptible pathogens with a minimum inhibitory concentration (MIC) of = Keywords: Pharmacokinetics, florfenicol, rabbit, flunixin, tenoxicam, lipopolysaccharide Full Text: PDF

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:The purpose of this study was to investigate the influences of flunixin (FM) and tenoxicam (TN) on the pharmacokinetics of florfenicol (FF) after coadministration in lipopolysaccharide (LPS)-induced endotoxemic rabbits.
📊
Temel Bulgular & Veri:FF (20 mg/kg), FM (2 mg/kg), and TN (1 mg/kg) were coadministered via intravenous injection to the animals.
💡
Sonuç & Katkı:When FF is coadministered with FM and TN, it can be given at a dose of 20 mg/kg b.w. every 8 h for treatment of infections caused by susceptible pathogens with a minimum inhibitory concentration (MIC) of = Keywords: Pharmacokinetics, florfenicol, rabbit, flunixin, tenoxicam, lipopolysaccharide Full Text: PDF
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Pharmacokinetics · florfenicol · rabbit

Özet

The purpose of this study was to investigate the influences of flunixin (FM) and tenoxicam (TN) on the pharmacokinetics of florfenicol (FF) after coadministration in lipopolysaccharide (LPS)-induced endotoxemic rabbits. Fifteen male rabbits were used in this study. FF (20 mg/kg), FM (2 mg/kg), and TN (1 mg/kg) were coadministered via intravenous injection to the animals. The concentrations of FF were determined by high-performance liquid chromatography with diode-array detection from 0.08 to 12 h in plasma. The plasma concentration-time profile of FF was described using a noncompartmental open model. In this study, terminal half-life, area under the curve, mean residence time, and volume of distribution at steady state were significantly increased, whereas total body clearance was decreased in coadministered groups. In conclusion, FM and TN have effects on the pharmacokinetics of FF in coadministered endotoxemic rabbits. When FF is coadministered with FM and TN, it can be given at a dose of 20 mg/kg b.w. every 8 h for treatment of infections caused by susceptible pathogens with a minimum inhibitory concentration (MIC) of = Keywords: Pharmacokinetics, florfenicol, rabbit, flunixin, tenoxicam, lipopolysaccharide Full Text: PDF

Abstract

The purpose of this study was to investigate the influences of flunixin (FM) and tenoxicam (TN) on the pharmacokinetics of florfenicol (FF) after coadministration in lipopolysaccharide (LPS)-induced endotoxemic rabbits. Fifteen male rabbits were used in this study. FF (20 mg/kg), FM (2 mg/kg), and TN (1 mg/kg) were coadministered via intravenous injection to the animals. The concentrations of FF were determined by high-performance liquid chromatography with diode-array detection from 0.08 to 12 h in plasma. The plasma concentration-time profile of FF was described using a noncompartmental open model. In this study, terminal half-life, area under the curve, mean residence time, and volume of distribution at steady state were significantly increased, whereas total body clearance was decreased in coadministered groups. In conclusion, FM and TN have effects on the pharmacokinetics of FF in coadministered endotoxemic rabbits. When FF is coadministered with FM and TN, it can be given at a dose of 20 mg/kg b.w. every 8 h for treatment of infections caused by susceptible pathogens with a minimum inhibitory concentration (MIC) of = Keywords: Pharmacokinetics, florfenicol, rabbit, flunixin, tenoxicam, lipopolysaccharide Full Text: PDF

🔖

Bu Makaleye Atıf Yap

KOÇ, F., ATİLA, A., KARAKUŞ, E., ÜNEY, K. (2015). Influences of flunixin and tenoxicam on the pharmacokinetics of florfenicol in lipopolysaccharide-induced endotoxemia. Turkish Journal of Veterinary and Animal Sciences, Cilt: 39 - Sayı: 2, 168–173. https://ajindex.com/articles/121428

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (11)

  1. Papich MG, Riviere JE. Chloramphenicol and derivatives, macrolides, lincosamides and miscellaneous antimicrobials. In: Adams HR, editor. Veterinary Pharmacology and Therapeutics. 8th ed. Ames, IA, USA: Iowa State University Press; 2001. pp. 868–897. Verbeeck RK. Pharmacokinetic drug interactions with nonsteroidal anti-inflammatory drugs. Clin Pharmacokinet 1990; 19: 44–66.
  2. Li JZ, Fung KF, Chen ZL, Zhang J. Tissue pharmacokinetics of florfenicol in pigs experimentally infected with Actinobacillus pleuropneumoniae. Eur J Drug Metab Pharmacokinet 2002; 27: 265–271.
  3. El-Aty AM, Goudah A, El-Sooud KA, El-Zorba HY, Shimoda M, Zhou HH. Pharmacokinetics and bioavailability of florfenicol following intravenous, intramuscular and oral administrations in rabbits. Vet Res Commun 2004; 28: 515– 524. Park BK, Lim JH, Kim MS, Hwang YH, Yun HI. Pharmacokinetics of florfenicol and its major metabolite, florfenicol amine, in rabbits. J Vet Pharmacol Ther 2007; 30: 32–36.
  4. Koc F, Ozturk M, Kadioglu Y, Dogan E, Yanmaz LE, Okumus Z. Pharmacokinetics of florfenicol after intravenous and intramuscular administration in New Zealand White rabbits. Res Vet Sci 2009; 87: 102–105.
  5. Koc F, Uney K, Ozturk M, Kadioglu Y, Atila A. Pharmacokinetics and bioavailability of florfenicol in the plasma of Japanese quails. New Zeal Vet J 2009; 57: 388–391.
  6. Atef M, El-Gendi AY, Amer AM, El-Aty AM. Effect of three anthelmentics on disposition kinetics of florfenicol in goats. Food Chem Toxicol 2010; 48: 3340–3344.
  7. Kim EY, Gebru E, Lee JS, Kim JC, Park SC. Pharmacokinetics of a florfenicol-tylosin combination after intravenous and intramuscular administration to beagle dogs. J Vet Med Sci 2011; 73: 463–466.
  8. Wang G, Tu P, Chen X, Guo YG, Jiang SX. Effect of three polyether ionophores on pharmacokinetics of florfenicol in male broilers. J Vet Pharmacol Ther 2013; 36: 494–501.
  9. Koc F, Atila A, Karakus E, Cetin N. Determination of florfenicol in plasma of rabbits by high-performance liquid chromatography after solid phase extraction. J Vet Pharmacol Ther 2012; 35: 89–89. Turnidge JD. The pharmacodynamics of beta-lactams. Clin Infect Dis 1998; 27: 10–22.
  10. Priebe S, Schwarz S. In vitro activities of florfenicol against bovine and porcine respiratory tract pathogens. Antimicrob Agents Chemother 2003; 47: 2703–2705.
  11. Kehrenberg C, Mumme J, Wallmann J, Verspohl J, Tegeler R, Kühn T, Schwarz S. Monitoring of florfenicol susceptibility among bovine and porcine respiratory tract pathogens collected in Germany during