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Dergiler / Turkish Journal of Veterinary and Animal Sciences / 2015 / Cilt: 39 - Sayı: 6

Effects of Epimedium polysaccharide on female mouse (Mus musculus)ovarian and uterine development

SETH YAW AFEDO
YAPING XU
CAROLINE WANJIKU MUNERI
GUOCHAO NI
WEICHAO XU
RONG RUI
Sayfa
714–718
Yayın Tarihi
2015-12-04
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In conclusion, EPS at appreciable dosages has a positive effect on mouse ovarian development.

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Amaç & Hipotez:This study was conducted to investigate the effects of Epimedium polysaccharide (EPS) on ovarian and uterine development in female mice and assess the in vitro maturation (IVM) rate.
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Temel Bulgular & Veri:Healthy Kunming female mice were divided into 4 groups and administered 2, 4, 6, and 8 mg/0.1 mL of EPS, respectively; the control group was given 0.1 mL of 0.9% physiological saline solution.
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Sonuç & Katkı:In conclusion, EPS at appreciable dosages has a positive effect on mouse ovarian development.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Epimedium polysaccharide · ovaries · development

Özet

This study was conducted to investigate the effects of Epimedium polysaccharide (EPS) on ovarian and uterine development in female mice and assess the in vitro maturation (IVM) rate. Healthy Kunming female mice were divided into 4 groups and administered 2, 4, 6, and 8 mg/0.1 mL of EPS, respectively; the control group was given 0.1 mL of 0.9% physiological saline solution. After 7 and 14 days, the mice were sacrificed and their reproductive tracts (uterus, oviduct, and ovaries) were removed. The reproductive tract was weighed; some ovaries were punctured to harvest oocytes for IVM culture and the others were used for histological analysis. EPS had virtually no effect on the body weight of the female mice. EPS at 4 mg/0.1 mL for 14 days of treatment had a significant effect (P < 0.05) on ovarian and uterine development when compared with 2, 6, and 8 mg/mL but no significant effect (P > 0.05) when compared with the control group. The number of follicles increased in the experimental groups and the arrangements of ovarian follicles were not negatively affected during histological observation. In conclusion, EPS at appreciable dosages has a positive effect on mouse ovarian development.

Abstract

This study was conducted to investigate the effects of Epimedium polysaccharide (EPS) on ovarian and uterine development in female mice and assess the in vitro maturation (IVM) rate. Healthy Kunming female mice were divided into 4 groups and administered 2, 4, 6, and 8 mg/0.1 mL of EPS, respectively; the control group was given 0.1 mL of 0.9% physiological saline solution. After 7 and 14 days, the mice were sacrificed and their reproductive tracts (uterus, oviduct, and ovaries) were removed. The reproductive tract was weighed; some ovaries were punctured to harvest oocytes for IVM culture and the others were used for histological analysis. EPS had virtually no effect on the body weight of the female mice. EPS at 4 mg/0.1 mL for 14 days of treatment had a significant effect (P < 0.05) on ovarian and uterine development when compared with 2, 6, and 8 mg/mL but no significant effect (P > 0.05) when compared with the control group. The number of follicles increased in the experimental groups and the arrangements of ovarian follicles were not negatively affected during histological observation. In conclusion, EPS at appreciable dosages has a positive effect on mouse ovarian development.

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Bu Makaleye Atıf Yap

AFEDO, S. Y., XU, Y., MUNERI, C. W., NI, G., XU, W., RUI, R. (2015). Effects of Epimedium polysaccharide on female mouse (Mus musculus)ovarian and uterine development. Turkish Journal of Veterinary and Animal Sciences, Cilt: 39 - Sayı: 6, 714–718. https://ajindex.com/articles/121329

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Kaynakça (14)

  1. National Commission of Chinese Pharmacopoeia. Pharmacopoeia of the Peoples’ Republic of China. Beijing, China: Chemical Industry Press; 2005.
  2. Chen Y, Wang J, Jia X, Tan X, Hu M. Role of intestinal hydrolase in the absorption of prenylated flavonoids present in yinyanghuo. Molecules 2011; 16: 1336–1348.
  3. Shindel AW, Xin ZC, Lin G, Fandel TM, Huang YC, Banie L, Breyer BN, Garcia MM, Lin CS, Lue TF. Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo. J Sex Med 2010; 7: 1518–1528.
  4. Kong X, Hu YL, Rui R, Wang D, Li X. Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer vaccination in chicken. Int Immunopharmacol 2004; 4: 975–982.
  5. Liu JX, Wang CY, Bai YM, Fang YP. Influence of Astragalus and other nine natural medicines on Newcastle disease antibody titers (ND-HI), coefficient of the immune organs and gains of chicks. Chin J Vet Sci Technol 1998; 12: 30–32.
  6. Lee M, Choi Y, Sung S, Shin D, Kim J, Kim Y. Antihepatotoxic activity of icariin, a major constituent of Epimedium koreanum. Planta Med 1995; 61: 523–526.
  7. Wu H, Lien EJ, Lien LL. Chemical and pharmacological investigations of Epimedium species: a survey. Prog Drug Res 2003; 60: 1–57.
  8. Meng F, Li Y, Xiong Z, Jiang Z, Li F. Osteoblastic proliferative activity of Epimedium brevicornum Maxim. Phytomedicine 2005; 12: 189–193.
  9. Glazier MG, Bowman MA. A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy. Arch Intern Med 2001; 161: 1161–1172.
  10. Denaeyer A, Pocock V, Milligan S, Dekeukeleire D. Estrogenic activity of a polyphenolic extract of the leaves. Fitoterapia 2005; 76: 35–40.
  11. Yap SP, Shen P, Li J, Lee LS, Yong EL. Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb Epimedium. J Ethnopharmacol 2007; 113: 218–224. Gougeon A. Dynamics of follicular growth in the human: a model from preliminary results. Hum Reprod 1986; 1: 81–87.
  12. Garber JC, Barbee RW, Bielitzki JT, Clayton LA, Donovan JC, Hendriksen CFM, Kohn DF, Lipman NS, Locke PA, Melcher J et al. Guide for the Care and Use of Laboratory Animals. 8th ed. Washington, DC, USA: National Academy Press; 2011.
  13. Behringer R, Gertsenstein M, Nagy K, Nagy A. Manipulating the Mouse Embryo: A Laboratory Manual. 4th ed. Cold Spring Harbor, NY, USA: Cold Spring Harbor Laboratory Press; 2003.
  14. Pan Y, Kong LD, Li YC, Xia, X, Kung HF, J