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Dergiler / Journal of Basic and Clinical Health Sciences / 2026 / Volume: 3 Issue: 2

Limitations of Cross-Talk Between Osteosarcoma and Bone Marrow-Derived Mesenchymal Stem Cells

Yasemin Basbinar(Dokuz Eylul University, Institute of Oncology, Translational Oncology Department, Izmir, Turkey)
Tugba Uysal(Dokuz Eylul University, Institute of Oncology, Translational Oncology Department, Izmir, Turkey)
Caner Karaca(Dokuz Eylul University, Institute of Health Sciences, Department of Oncology, Izmir, Turkey)
Ezgi Daskin(Dokuz Eylul University, Institute of Oncology, Translational Oncology Department, Izmir, Turkey)
Hanife Ecenur Meco(Dokuz Eylul University, Institute of Oncology, Translational Oncology Department, Izmir, Turkey)
Ahu Pakdemirli(Dokuz Eylul University, Vocational School of Health Services, Department of First and Emergency Aid, Izmir, Turkey)
Turkan Yigitbasi(Istanbul Medipol University, Faculty of Medicine, Department of Biochemistry, Istanbul, Turkey)
Hulya Ellidokuz(Dokuz Eylul University Oncology Institute Department of Preventive Oncology, School of Medicine Department of Biostatistics and Medical Informatics, Izmir, Turkey.)
Sayfa
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Yayın Tarihi
2019-06-01
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Mann Whitney U Test was used to compare independent samples.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objectives: Metastasis is a multi-step process which leads the tumor cells to escape from primer tumor region due to their need to gain malign phenotypes.
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Temel Bulgular & Veri:Cross-talk via soluble factors also shifts the metastatic character.Patients and Methods: In this study, the effects of mesenchymal stem cells on tumor behavior by creating different microenvironments in 3-dimensional 3D in vitro cancer model is analyzed.
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Sonuç & Katkı:Mann Whitney U Test was used to compare independent samples.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Osteosarcoma · MG-63 · BM-MSCs

Abstract

Objectives: Metastasis is a multi-step process which leads the tumor cells to escape from primer tumor region due to their need to gain malign phenotypes. While the effect of bone marrow-derived mesenchymal stem cells upon metastasis is not certain, some studies point out bone marrow-derived mesenchymal stem cells BM-MSCs to have this ability due to cell-cell interaction, released cytokines, and organization with the extracellular matrix in the micro-environment. Cross-talk via soluble factors also shifts the metastatic character.Patients and Methods: In this study, the effects of mesenchymal stem cells on tumor behavior by creating different microenvironments in 3-dimensional 3D in vitro cancer model is analyzed. The BM-MSCs and osteosarcoma cells were co-cultured via hanging-drop modeled 3D structure in normoxic and hypoxic conditions, and the cross-talk was modeled to measure their chemoattractant effects. The invasion and migration rates were measured with xCELLigence DP real-time cell analysis system. Mann Whitney U Test was used to compare independent samples. All P-values

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Bu Makaleye Atıf Yap

Basbinar, Y., Uysal, T., Karaca, C., Daskin, E., Meco, H. E., Pakdemirli, A., Yigitbasi, T., Ellidokuz, H. (2019). Limitations of Cross-Talk Between Osteosarcoma and Bone Marrow-Derived Mesenchymal Stem Cells. Journal of Basic and Clinical Health Sciences, Volume: 3 Issue: 2. https://doi.org/10.30621/jbachs.2019.611

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