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Dergiler / Sağlık Bilimleri Dergisi / 2026 / Cilt: 28 Sayı: 2

TİYENİL-TİYAZOL-ARİL-TİYOÜRE HİBRİT MOLEKÜLLERİN SENTEZİ VE BİYOLOJİK AKTİVİTELERİNİN APOPTOTİK YOL ÜZERİNDEN ANTİ-KANSER ETKİLERİNİN ARAŞTIRILMASI

Şengül Dilem Doğan(ERCİYES ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ)0000-0003-1761-188X
Sümeyye Uğur
Ayşe Kübra Karaboğa Arslan
Ebru Öztürk
Ahmet Cumaoğlu
Mükerrem Betül Yerer
Sayfa
87–93
Yayın Tarihi
2019-09-20
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Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bir triflorometil (-CF 3 ) grubunu içeren 4e molekülü bir anti-kanserojen madde olarak düşünülebilir ve daha ileri araştırmalar yapılabilir.0000-0003-1761-188X

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Tiyenil-tiyazol-aril-tiyoüre türevleri ( 4a - 4e ) amino-4-(2-tiyenil)tiyazol ve fenilizotiyasiyanatların reaksiyonları sonucu sentezlenmiştir.
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Temel Bulgular & Veri:Sentezlenen bileşikler IR, 1 H-NMR ve kütle spektrumları ile karekterize edildi.
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Sonuç & Katkı:Bir triflorometil (-CF 3 ) grubunu içeren 4e molekülü bir anti-kanserojen madde olarak düşünülebilir ve daha ileri araştırmalar yapılabilir.0000-0003-1761-188X
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Tiyoüre · Antikanser activite · Tiyazol

Özet

Tiyenil-tiyazol-aril-tiyoüre türevleri ( 4a - 4e ) amino-4-(2-tiyenil)tiyazol ve fenilizotiyasiyanatların reaksiyonları sonucu sentezlenmiştir. Sentezlenen bileşikler IR, 1 H-NMR ve kütle spektrumları ile karekterize edildi. Beş tiyoüre türevinin anti-proliferatif etkileri A549 (KHDAK) hücrelerinde gerçek zamanlı hücre analizörü xCELLigence sistemi ile incelendi. Gerçek zamanlı sistemde sitotoksik olduğu gösterilmiş olan 2 tiyoürenin moleküler etki mekanizmaları, mitokondriyal membran potansiyeli ΔψM spektrofotometrik olarak, sitokrom c western blot methoduyla ve Bcl-2 ise qRT-PCR ile araştırılmıştır. 4e diğerlerinden daha etkili bulunmuştur. 4e IC 50 değerleri 24 ve 48 saat için sırasıyla 29,6 µM ve 22,3 µM olarak hesaplanmıştır. Bir triflorometil (-CF 3 ) grubunu içeren 4e molekülü bir anti-kanserojen madde olarak düşünülebilir ve daha ileri araştırmalar yapılabilir.0000-0003-1761-188X

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Bu Makaleye Atıf Yap

Doğan, Ş. D., Uğur, S., Arslan, A. K. K., Öztürk, E., Cumaoğlu, A., Yerer, M. B. (2019). TİYENİL-TİYAZOL-ARİL-TİYOÜRE HİBRİT MOLEKÜLLERİN SENTEZİ VE BİYOLOJİK AKTİVİTELERİNİN APOPTOTİK YOL ÜZERİNDEN ANTİ-KANSER ETKİLERİNİN ARAŞTIRILMASI. Sağlık Bilimleri Dergisi, Cilt: 28 Sayı: 2, 87–93. https://doi.org/10.34108/eujhs.493005

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