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Dergiler / ENT Updates / 2026 / Cilt: 9 Sayı: 1

Correlation of Histopathological Findings in Laryngeal Squamous Cell Carcinoma with Inflammatory Biomarkers

İldem Deveci(Health Science University Umraniye Education and Research Hospital, Department of Otorhinolaryngology, Istanbul Turkey)
Mehmet Surmeli(Health Science University Umraniye Education and Research Hospital, Department of Otorhinolaryngology, Istanbul Turkey)
Serap Onder(Health Science University Umraniye Education and Research Hospital, Department of Otorhinolaryngology, Istanbul Turkey)
Burak Karabulut(4Health Science UniversiUmraniye Education and Research Hospital, Department of Otorhinolaryngology, Istanbul Turkey)
Hande Senem Deveci(Health Science University Fatih Sultan Mehmet Education and Research Hospital, Department of Otorhinolaryngology, Istanbul Turkey)
Cagatay Oysu(Marmara University, Department of Otorhinolaryngology)
Sayfa
44–52
Yayın Tarihi
2019-03-19
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

It can provide important clues to the likelihood of perineural or lymphatic involvement in cases of LSCC.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective:  The goal of this research was to investigate how biomarkers, i.e.
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Temel Bulgular & Veri:Methods: A retrospective review of clinical records from 146 cases (143 men and 3 women) of LSCC occurring between January 2008 and January 2018 was undertaken.
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Sonuç & Katkı:It can provide important clues to the likelihood of perineural or lymphatic involvement in cases of LSCC.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:2008 Verileri
⚙️Değişkenler:Laryngeal squamous cell carcinoma · inflammatory biomarkers · Laryngeal squamous cell carcinoma

Abstract

Objective:&nbsp; The goal of this research was to investigate how biomarkers, i.e. SII (an index calculated from blood counts of various leucocytes), NLR and MLR correlate with features used in the staging of laryngeal squamous cell carcinoma (LSCC), i.e. perineural infiltration, lymphatic involvement and histological grade. Methods: A retrospective review of clinical records from 146 cases (143 men and 3 women) of LSCC occurring between January 2008 and January 2018 was undertaken. The sample included every stage of LSCC and all biomarker results were found from the full blood count (FBC) results obtained prior to surgery and documented for each case. SII is a newly introduced index of inflammation calculated according to the formula: SII = NxP/L, where N represents neutrophil, P platelet and L lymphocyte counts.&nbsp;&nbsp;Histopathological parameters (presence of perineural or lymphatic involvement, grade of tumour) were evaluated alongside results for NLR, MLR and SII. Results: All three biomarkers were different at the level of statistical significance between individuals with LSCC and the controls. For NLR, p=0.003; for MLR, p=0.008; for SII, p<0.001. Both NLR and SII were different at a statistically significant level when compared at early and advanced stages of LSCC (p values were 0.011 and <0.001, respectively. MLR did not differ at the level of statistical significance (p=0.944). (See Table 3). Conclusion: SII is straightforward to calculate, economical and reproducible from FBC results. It can provide important clues to the likelihood of perineural or lymphatic involvement in cases of LSCC.

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Bu Makaleye Atıf Yap

Deveci, İ., Surmeli, M., Onder, S., Karabulut, B., Deveci, H. S., Oysu, C. (2019). Correlation of Histopathological Findings in Laryngeal Squamous Cell Carcinoma with Inflammatory Biomarkers. ENT Updates, Cilt: 9 Sayı: 1, 44–52. https://ajindex.com/articles/1205337

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