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Dergiler / Dicle Tıp Dergisi / 2026 / Cilt: 41 Sayı: 1

Evaluation of protein and lipid oxidative stress in the patients with postmenopausal osteoporosis

Banu Çavdaroğlu
Nurgül Köse
Gülden Başkol
Hüseyin Demir
Sayfa
71–77
Yayın Tarihi
2014-03-01
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bulgular: Serum MDA, AOPP ve thiol seviyeleri kontrol grubuna göre hastalarda istatistiksel olarak anlamlı derecede yüksekti (p

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amaç: Oksidatif stres, osteoporozu da içeren pek çok patolojik durumda hücresel fonksiyonları değiştirebilir.
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Temel Bulgular & Veri:Biz bu çalışmada postmenopozal osteoporozlu hastalarda oksidatif stresi değerlendirmek için, reaktif oksijen türleri (ROS) ile indüklenen lipid peroksidasyonu son ürünü malondialdehit (MDA), protein oksidasyonu son ürünü ileri düzey protein oksidasyonu ürünleri (AOPP), antioksidan olarak bilinen Thiol, lipid antioksidanı olarak bilinen serum paraoxonase 1 (PON 1) aktivitesini belirlemeyi amaçladık.
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Sonuç & Katkı:Bulgular: Serum MDA, AOPP ve thiol seviyeleri kontrol grubuna göre hastalarda istatistiksel olarak anlamlı derecede yüksekti (p
🔬Tür:Makale
📍Kapsam:59 hasta
⚙️Değişkenler:Lipid peroksidasyonu · protein oksidasyonu · osteoporoz

Özet

Amaç: Oksidatif stres, osteoporozu da içeren pek çok patolojik durumda hücresel fonksiyonları değiştirebilir. Biz bu çalışmada postmenopozal osteoporozlu hastalarda oksidatif stresi değerlendirmek için, reaktif oksijen türleri (ROS) ile indüklenen lipid peroksidasyonu son ürünü malondialdehit (MDA), protein oksidasyonu son ürünü ileri düzey protein oksidasyonu ürünleri (AOPP), antioksidan olarak bilinen Thiol, lipid antioksidanı olarak bilinen serum paraoxonase 1 (PON 1) aktivitesini belirlemeyi amaçladık. Yöntemler: Bu çalışmaya postmenopozal osteoporoz tanısı konan 59 hasta alındı. 21 sağlıklı kontrol grubuyla karşılaştırması yapıldı. Serum AOPP, MDA, thiol düzeyleri ve PON 1 aktivitesi enzimatik spektrofotometrik metotla ölçüldü. Bulgular: Serum MDA, AOPP ve thiol seviyeleri kontrol grubuna göre hastalarda istatistiksel olarak anlamlı derecede yüksekti (p

Abstract

Objective: Oxidative stress may change cellular function in multiple pathological conditions, including osteoporosis. We aimed to determine malondialdehyde (MDA) levels, advanced oxidation protein pruducts (AOPP), levels end products of protein oxidation, thiol as known antioxidant, serum paraoxonase 1 (PON1) activities as known lipid antioxidant, induced by reactive oxygen species (ROS) for evaluating oxidative stress in osteoporotic patients. Methods: 59 patients diagnosed with postmenopaual osteoporosis were included in the study and compared with 21 healthy controls. Serum AOPP, MDA, thiol levels and PON1 activity were measured according to an enzymatic spectrophotometric method. Results: The serum MDA, AOPP, and thiol levels was significantly higher in the patient group than controls (p

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Bu Makaleye Atıf Yap

Çavdaroğlu, B., Köse, N., Başkol, G., Demir, H. (2014). Evaluation of protein and lipid oxidative stress in the patients with postmenopausal osteoporosis. Dicle Tıp Dergisi, Cilt: 41 Sayı: 1, 71–77. https://doi.org/10.5798/diclemedj.0921.2014.01.0375

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