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Dergiler / Çocuk Dergisi / 2026 / Cilt: 25 Sayı: 2

Long-Term Clinical Follow-Up Results in Patients with Pediatric Valvular Aortic Stenosis: A Single Center Experience

Serra Karaca(ISTANBUL MEDIPOL UNIVERSITY, INTERNATIONAL FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF PEDIATRICS, PEDIATRIC CARDIOLOGY)0000-0001-5421-0191
Doruk Özbingöl(ISTANBUL MEDIPOL UNIVERSITY, INTERNATIONAL FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF PEDIATRICS, PEDIATRIC CARDIOLOGY)0009-0009-7103-7066
Kazım Öztarhan(ISTANBUL MEDIPOL UNIVERSITY, INTERNATIONAL FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF PEDIATRICS, PEDIATRIC CARDIOLOGY)0000-0001-9919-1414
Kemal Nişli(ISTANBUL MEDIPOL UNIVERSITY, INTERNATIONAL FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF PEDIATRICS, PEDIATRIC CARDIOLOGY)0000-0001-9085-9852
Sayfa
91–96
Yayın Tarihi
2025-09-12
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

However, the risks of AR and reintervention warrant careful patient selection and long-term follow-up.

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Amaç & Hipotez:Objective: This study aimed to evaluate the long-term clinical outcomes of pediatric patients with valvular aortic stenosis (VAS) treated at a single tertiary center, with a focus on the efficacy and safety of balloon aortic valvuloplasty (BAV).
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Temel Bulgular & Veri:Materials and Methods: A total of 450 pediatric patients diagnosed with VAS between 2001 and 2023 were retrospectively reviewed.
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Sonuç & Katkı:However, the risks of AR and reintervention warrant careful patient selection and long-term follow-up.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:2001 Verileri
⚙️Değişkenler:Valvular aortic stenosis · balloon valvuloplasty · follow-up

Abstract

Objective: This study aimed to evaluate the long-term clinical outcomes of pediatric patients with valvular aortic stenosis (VAS) treated at a single tertiary center, with a focus on the efficacy and safety of balloon aortic valvuloplasty (BAV). Materials and Methods: A total of 450 pediatric patients diagnosed with VAS between 2001 and 2023 were retrospectively reviewed. Clinical, echocardiographic, and angiographic data were analyzed. Among these, 130 patients who underwent BAV for moderate-to-severe or critical stenosis were evaluated in detail. Hemodynamic changes, procedural complications, development of aortic regurgitation (AR), and reintervention rates were recorded. Results: The cohort had a mean age of 120.6 ± 55.8 months, and 74.5% were male. The mean follow-up duration was 5.2 years (range: 1–17 years). The bicuspid aortic valve was the most common morphology (75.5%). Among the 130 patients who underwent balloon aortic valvuloplasty (BAV), the age at angiography was <1 month in 27.6%, 1–12 months in 16.9%, 12–60 months in 16.1%, 60–120 months in 20.7%, and >120 months in 15.3% of cases. BAV resulted in a significant reduction in left ventricular pressure (from 171.6 to 135.2 mmHg) and systolic gradient (from 83.9 to 32.3 mmHg). AR developed in 84.6% of patients post BAV, but only 2.5% had severe regurgitation. Repeat BAV was required in 10.7% of patients, and 3.2% were referred for surgical intervention. Four neonates with critical of and pre-existing LV dysfunction died. Conclusion: BAV is an effective and minimally invasive intervention for pediatric VAS, offering substantial short- to mid-term relief from obstruction. However, the risks of AR and reintervention warrant careful patient selection and long-term follow-up.

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Bu Makaleye Atıf Yap

Karaca, S., Özbingöl, D., Öztarhan, K., Nişli, K. (2025). Long-Term Clinical Follow-Up Results in Patients with Pediatric Valvular Aortic Stenosis: A Single Center Experience. Çocuk Dergisi, Cilt: 25 Sayı: 2, 91–96. https://doi.org/10.26650/jchild.2025.1691410

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