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Dergiler / Çocuk Dergisi / 2026 / Cilt: 26 Sayı: 1

Evaluation of Children with Suspected Penicillin Allergy: A Single-Center Study

Kazım Okan Dolu(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL KANUNİ SULTAN SÜLEYMAN SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0003-0741-6749
İdan Fırat Unay(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL KANUNİ SULTAN SÜLEYMAN SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, ÇOCUK ALERJİ VE İMMÜNOLOJİ BİLİM DALI)0009-0001-0330-1146
Yasemin Tepe(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL KANUNİ SULTAN SÜLEYMAN SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, ÇOCUK ALERJİ VE İMMÜNOLOJİ BİLİM DALI)0000-0002-1188-3131
Zeynep Efşan Başer Sinoplu(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL KANUNİ SULTAN SÜLEYMAN SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, ÇOCUK ALERJİ VE İMMÜNOLOJİ BİLİM DALI)0000-0002-5557-4218
Hande Üçler Çınar(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL KANUNİ SULTAN SÜLEYMAN SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, ÇOCUK ALERJİ VE İMMÜNOLOJİ BİLİM DALI)0000-0003-4722-1145
Elanur Yolal Karimov(İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, ÇOCUK SAĞLIĞI ENSTİTÜSÜ, SOSYAL PEDİATRİ DOKTORA PROGRAMI, İSTANBUL, TÜRKİYE)0000-0002-1154-0673
Çağla Karavaizoğlu(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL BAŞAKŞEHİR ÇAM VE SAKURA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, ÇOCUK LAERJİ VE İMMÜNOLOJİ BİLİM DALI)0009-0005-3898-4767
H. Haluk Akar(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL KANUNİ SULTAN SÜLEYMAN SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, ÇOCUK ALERJİ VE İMMÜNOLOJİ BİLİM DALI)0000-0002-7266-5445
Sayfa
22–30
Yayın Tarihi
2026-06-15
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Direct drug provocation testing is safe and effective in low-to-moderate-risk patients.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: This study aimed to systematically evaluate pediatric patients referred with suspected penicillin allergy and determine the rate of confirmed penicillin allergy.
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Temel Bulgular & Veri:Materials and Methods: A retrospective study was conducted on 57 patients who presented to the Pediatric Allergy and Immunology Department of Istanbul Kanuni Sultan Süleyman Training and Research Hospital with suspected penicillin allergy between August 2023 and August 2025.
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Sonuç & Katkı:Direct drug provocation testing is safe and effective in low-to-moderate-risk patients.
🔬Tür:Araştırma Makalesi
📍Kapsam:2023 Verileri
⚙️Değişkenler:Penicillin allergy · Child · Drug provocation test

Abstract

Objective: This study aimed to systematically evaluate pediatric patients referred with suspected penicillin allergy and determine the rate of confirmed penicillin allergy. Materials and Methods: A retrospective study was conducted on 57 patients who presented to the Pediatric Allergy and Immunology Department of Istanbul Kanuni Sultan Süleyman Training and Research Hospital with suspected penicillin allergy between August 2023 and August 2025. All patients underwent specific IgE testing for amoxicillin, ampicillin, penicillin G, and penicillin V. Skin testing was performed in patients with parenteral drug reactions. Oral drug provocation testing was conducted in patients with negative specific IgE and skin tests. Results: The mean age was 7.4±4.9 years (median: 6 years). The most common suspected drug was amoxicillin-clavulanate (77.2%). Urticaria/angioedema (61.4%) was the most frequent reaction type. Specific IgE positivity was detected in only 3 patients (5.3%). Drug provocation testing was performed in 53 patients, with 51 patients (96.2%) tolerating the drug without complications and 2 patients (3.8%) showing positive reactions. Penicillin allergy was confirmed in 6 patients (10.5%), whereas it was excluded (delabeled) in 51 patients (89.5%). Conclusion: Our study demonstrated that 89.5% of penicillin allergy labels were incorrect. The low sensitivity of specific IgE testing was confirmed. Direct drug provocation testing is safe and effective in low-to-moderate-risk patients.

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Bu Makaleye Atıf Yap

Dolu, K. O., Unay, İ. F., Tepe, Y., Sinoplu, Z. E. B., Çınar, H. Ü., Karimov, E. Y., Karavaizoğlu, Ç., Akar, H. H. (2026). Evaluation of Children with Suspected Penicillin Allergy: A Single-Center Study. Çocuk Dergisi, Cilt: 26 Sayı: 1, 22–30. https://doi.org/10.26650/jchild.2026.1844933

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Kaynakça (19)

  1. Taylor MG, Joerger T, Anvari S, Li Y, Gerber JS, Palazzi DL. Quality and Management of Penicillin Allergy Labels in Pediatric Primary Care. Pediatrics. 2023;151(3). google scholar
  2. Ibáñez MD, Rodríguez Del Río P, Lasa EM, Joral A, Ruiz-Hornillos J, Muñoz C, et al. Prospective assessment of diagnostic tests for pediatric penicillin allergy: From clinical history to challenge tests. Ann Allergy Asthma Immunol. 2018;121(2):235-44.e3. google scholar
  3. Vyles D, Adams J, Chiu A, Simpson P, Nimmer M, Brousseau DC. Allergy Testing in Children with Low-Risk Penicillin Allergy Symptoms. Pediatrics. 2017;140(2). google scholar
  4. Shenoy ES, Macy E, Rowe T, Blumenthal KG. Evaluation and management of penicillin allergy: A review. Jama. 2019;321(2):188-99. google scholar
  5. Taylor MG, Joerger T, Li Y, Scheurer ME, Russo ME, Gerber JS, et al. Factors Associated with Penicillin Allergy Labels in Electronic Health Records of Children in 2 Large US Pediatric Primary Care Networks. JAMA Netw Open. 2022;5(3):e222117. google scholar
  6. Norton AE, Konvinse K, Phillips EJ, Broyles AD. Antibiotic allergies in pediatrics. Pediatrics. 2018;141(5). google scholar
  7. Rischin KJ, Mostaghim M, Rao A, Smith B, O'Brien TA, Trubiano JA, et al. ESCAPE-Allergy: Evaluating screening for children and adolescents with penicillin allergy. J Paediatr Child Health. 2022;58(1):83-9. google scholar
  8. Barbaud A, Garvey LH, Torres M, Laguna JJ, Arcolaci A, Bonadonna P, et al. EAACI/ENDA position paper on drug provocation testing. Allergy. 2024;79(3):565-79. google scholar
  9. Broyles AD, Banerji A, Castells M. Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: General Concepts. J Allergy Clin Immunol Pract. 2020;8(9s):S3-s15. google scholar
  10. Yağmur H, Atay Ö, Bakır DB, Kabadayı G, Boyacıoğlu Ö K, Ası̇lsoy S, et al. Evaluation of drug provocation tests without prior skin testing in children with suspected penicillin allergy and correlation with PEN-FAST: A single-center study. Eur J Pediatr. 2025;184(8):488. google scholar
  11. Brockow K, Wurpts G, Trautmann A, Pfützner W, Treudler R, Bircher AJ, et al. Guideline for allergological diagnosis of drug hypersensitivity reactions: S2k Guideline of the German Society for Allergology and Clinical Immunology in cooperation with the German Dermatological Society (DDG), the Association of German Allergologists (ÄDA), the German Society for Pediatric Allergology (GPA), the German Contact Dermatitis Research Group (DKG), the German Society for Pneumology (DGP), the German Society of Otorhinolaryngology, Head and Neck Surgery, the Austrian Society of Allergology and Immunology (ÖGAI), the Austrian Society of Dermatology and Venereology (ÖGDV), the German Academy of Allergology and Environmental Medicine (DAAU), and the German Documentation Center for Severe Skin Reactions (dZh). Allergol Select. 2023;7:122-39. google scholar
  12. Prieto A, Muñoz C, Bogas G, Fernández-Santamaría R, Palomares F, Mayorga C, et al. Single-dose prolonged drug provocation test, without previous skin testing, is safe for diagnosing children with mild non-immediate reactions to beta-lactams. Allergy. 2021;76(8):2544-54. google scholar
  13. Kitsos N, Cassimos D, Xinias I, Agakidis C, Mavroudi A. Management of antibiotic allergy in children: a practical approach. Allergy Immunopathol. 2022;50(5):30-8. google scholar
  14. Rebelo Gomes E, Fonseca J, Araujo L, Demoly P. Drug allergy claims in children: from self-reporting to confirmed diagnosis. Clin Exp Allergy. 2008;38(1):191-8. google scholar
  15. Mill C, Primeau MN, Medoff E, Lejtenyi C, O'Keefe A, Netchiporouk E, et al. Assessing The Diagnostic Properties of a Graded Oral Provocation Challenge for the Diagnosis of Immediate and Nonimmediate Reactions to Amoxicillin in Children. JAMA Pediatr. 2016;170(6):e160033. google scholar
  16. Güvenir FA, Emeksiz Z, Yörüsün G, Kuşaklı AK, Demir K, Selmanoğlu A, et al. PEN-FAST in pediatrics: a reliable tool for penicillin allergy assessment? Eur J Pediatr. 2025;184(7):463. Torres MJ, Ariza A, Mayorga C, et al. Clavulanic acid can be the component in amoxicillinclavulanic acid responsible for immediate hypersensitivity reactions. J Allergy Clin Immunol. 2010;125(2):502-505.e2. doi:10.1016/j.jaci.2009.11.03218. Romano A, Atanaskovic-Markovic M, Barbaud A, Bircher AJ, Brockow K, Caubet JC, et al. Toward a more precise diagnosis of hypersensitivity to beta-lactams - an EAACI position paper. Allergy. 2020;75(6):1300-15. google scholar
  17. Cardoso-Fernandes A, Blumenthal KG, Chiriac AM, Tarrio I, Afonso-João D, Delgado L, et al. Frequency Of severe reactions following penicillin drug provocation tests: A Bayesian meta-analysis. Clin Transl Allergy. 2021;11(4):e12008. google scholar
  18. Brockow K, Przybilla B, Aberer W, Bircher AJ, Brehler R, Dickel H, et al. Guideline for the diagnosis of drug hypersensitivity reactions: S2K-Guideline of the German Society for Allergology and Clinical Immunology (DGAKI) and the German Dermatological Society (DDG) in collaboration with the Association of German Allergologists (AeDA), the German Society for Pediatric Allergology and Environmental Medicine (GPA), the German Contact Dermatitis Research Group (DKG), the Swiss Society for Allergy and Immunology (SGAI), the Austrian Society for Allergology and Immunology (ÖGAI), the German Academy of Allergology and Environmental Medicine (DAAU), the German Center for Documentation of Severe Skin Reactions, and the German Federal Institute for Drugs and Medical Products (BfArM). Allergo J Int. 2015;24(3):94-105. google scholar
  19. Kwok M, Heard KL, May A, Pilgrim R, Sandoe J, Tansley S, et al. Health outcomes of penicillin allergy testing in children: a systematic review. J Antimicrob Chemother. 2023;78(4):913-22. google scholar