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Dergiler / Kocatepe Veteriner Dergisi / 2026 / Cilt: 19 Sayı: 2

Kıl Keçilerinde Serum Simetrik Dimetilarjinin Düzeyleri ile Üre, Kreatinin Düzeylerinin Yaşa Bağlı Karşılaştırılması

Age-Related Comparison of Serum Symmetrical Dimethylarginine Levels and Urea, Creatinine Levels in Hair Goats

Hasan İlbasan(MEHMET AKIF ERSOY UNIVERSITY)0009-0005-2861-7517
Burcu Menekşe Balkan(MEHMET AKIF ERSOY UNIVERSITY)0000-0002-0206-6455
Sayfa
220–228
Yayın Tarihi
2026-06-15
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Elde edilen bulgularla, hem farklı yaşlardaki dişi keçilerde SDMA düzeylerinin üre, kreatinin düzeyleri ile birlikte değerlendirilmesi hem de keçilerde SDMA düzeyleri konularında literatür bilgisine katkı sağlamaktadır.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:SDMA insan hem de hayvan modellerinde böbrek fonksiyonunu belirlemede önemli bir belirtecidir.
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Temel Bulgular & Veri:Böbrek fonksiyonu bozukluğu dışındaki kardiyovasküler risk faktörlerinin de SDMA plazma düzeylerini etkileyebileceği gösterilmiştir.
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Sonuç & Katkı:Elde edilen bulgularla, hem farklı yaşlardaki dişi keçilerde SDMA düzeylerinin üre, kreatinin düzeyleri ile birlikte değerlendirilmesi hem de keçilerde SDMA düzeyleri konularında literatür bilgisine katkı sağlamaktadır.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:40 adet
⚙️Değişkenler:Kıl keçisi · Kreatinin · Simetrik Dimetilarjinin

Özet

SDMA insan hem de hayvan modellerinde böbrek fonksiyonunu belirlemede önemli bir belirtecidir. Böbrek fonksiyonu bozukluğu dışındaki kardiyovasküler risk faktörlerinin de SDMA plazma düzeylerini etkileyebileceği gösterilmiştir. Farklı iklim koşullarına ve arazi tiplerine iyi adapte olan Kıl keçileri, Türkiye’de keçi yetiştiriciliğinde % 96 oran ile en çok yetiştirilen ırktır. Bu tez çalışmasında kıl keçilerinde kan serum Simetrik dimetilarjinin (SDMA), Üre ve Kreatinin düzeylerinin yaşa bağlı değişimlerinin araştırılması amaçlandı. Çalışmada aynı bakım ve besleme şartları altında barındırılan 40 adet dişi Kıl keçisi kullanıldı. Çalışma grupları, grupta 10 adet keçi olacak şekilde 0-12 ay (Grup 1), 1-2 yaş (Grup 2), 2-3 yaş (Grup 3), ve 3-4 yaş (Grup 4), olarak gruplandırıldı. Kan serum örneklerinde Simetrik Dimetil Arjinin analizi tayini ticari kit (SDMA) ELISA Kit protoküle uygun olarak yapıldı. Serum üre ve kreatinin düzeyleri ise otoanalizörde ölçüldü. Dişi keçilerde kan serumunda grup 1, 2, 3 ve 4 ‘de sırasıyla SDMA düzeyleri (ng/mL) 2,43±0,24, 3,21±0,44, 3,74±0,32 ve 4,46±0,59 (p=0,013); Üre düzeyleri (mg/dL) 20±1,87, 24,5±1,43, 24,4±1,82 ve 19,1±1,75 (p=0,058); Kreatinin düzeyleri (mg/dL) 0,35±0,027, 0,32±0,020, 0,34±0,022, 0,36±0,022 (p=0,648) olarak belirlenmiştir. Grup 3 ve 4’de elde edilen SDMA düzeyleri, grup 1 ve 2 ‘de elde edilen değerler göre değerlere göre istatistik olarak anlamlı yüksek bulunurken (p<0.05), üre ve kreatinin değerleri arasında anlamlı bir fark bulunamamıştır. Elde edilen bulgularla, hem farklı yaşlardaki dişi keçilerde SDMA düzeylerinin üre, kreatinin düzeyleri ile birlikte değerlendirilmesi hem de keçilerde SDMA düzeyleri konularında literatür bilgisine katkı sağlamaktadır.

Abstract

Symmetric dimethylarginine (SDMA) is an important marker for determining renal function in both humans and animal models. It has been shown that cardiovascular risk factors additional to renal dysfunction may affect SDMA plasma levels. Hair goats are the most bred breed in goat breeding in Turkey. In this study, it was aimed to investigate the age-related changes in blood serum SDMA, Urea and Creatinine levels in Hair goats. 40 female Hair goats, housed under the same care and feeding conditions, were used in the study. The study groups were grouped as 0-12 months (Group 1), 1-2 years (Group 2), 2-3 years (Group 3), and 3-4 years (Group 4), with 10 goats in each group. Symmetric Dimethyl Arginine levels in blood serum samples was measured with the commercial ELISA Kit. Serum urea and creatinine levels were measured with an autoanalyzer. SDMA levels in the blood serum of female goats in groups 1, 2, 3 and 4 were 2,43±0,24, 3.21±0.44, 3.74±0.32 and 4.46±0.59 (p =0.013); Urea levels (mg/dL) were 20±1.87, 24.5±1.43, 24.4±1.82 and 19.1±1.75 (p=0.058); Creatinine levels (mg/dL) were 0.35±0.027, 0.32±0.020, 0.34±0.022, 0.36±0.022 (p=0.648) respectively. While the SDMA levels (ng/mL) obtained in groups 3 and 4 were found to be statistically significantly higher than the values obtained in groups 1 and 2 (p<0.05), no significant difference was found between urea and creatinine values. The findings contribute to the literature knowledge on both the evaluation of SDMA levels and its comparation together with urea and creatinine levels in female goats of different ages.

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Bu Makaleye Atıf Yap

İlbasan, H., Balkan, B. M. (2026). Kıl Keçilerinde Serum Simetrik Dimetilarjinin Düzeyleri ile Üre, Kreatinin Düzeylerinin Yaşa Bağlı Karşılaştırılması. Kocatepe Veteriner Dergisi, Cilt: 19 Sayı: 2, 220–228. https://doi.org/10.30607/kvj.1880986

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